69 Best Engineering Startups in United States to Watch in 2025

Arzeda is a biotechnology and software company designing custom microorganisms for industrial applications through computational enzyme design, protein optimization, and metabolic engineering.

Company developing space manufacturing technologies to support exploration, national security, and sustainable space settlement.

Tempus, a technology company advancing precision medicine through the practical application of artificial intelligence in healthcare.

Finless Foods is a biotechnology company producing cultured marine animal food products through implementing cellular agriculture and manufacturing technologies.

Upside Foods is a San Francisco-based company making cultured meat products. The company was founded by Uma Valeti, Nicholas Genovese, and Will Clem.

Grail is a biotechnology company headquartered in Menlo Park, California that was founded as a spinoff of Illumina Inc and initially headed by Jeffrey Huber in 2016, focused on making a medical device that can detect early stage cancer.

Catalog is a Boston, Massachusetts-based company developing a platform for DNA-based digital data storage.

Synchron, Inc. is a technology company building implantable neural interface solutions, including endovascular brain-computer interface.

Notable Labs is a company providing personalized drug combination testing service for cancer patients.

A diagnostic DNA testing company using quantified biological data.

Aria Pharmaceuticals is a first-in-class pharmaceutical discovery and development founded in 2014 by Andrew M. Radin.

Senti Biosciences is a synthetic biology company.

Human Longevity is a genomic-based, health intelligence company empowering proactive healthcare and enabling a life better lived.

Genomatica is a San Diego-based company founded in 2000 by Christophe Schilling.

A cellular agriculture company making fresh and frozen cultured seafood products.

A biotechnology company developing engineered cell therapies for treating diseases in neurology, cardiology and autoimmunity.

A biotechnology company that develops medicines based on live bacterial consortia that can colonize the human intestine.

RoosterBio is a biotechnology company located in Frederick, Maryland, founded by Jon Rowley in 2013 providing standardized stem cell products for R&D, clinical, and commercial use in the regenerative medicine industry.

Orig3n is a biotechnology company developing personalized regenerative medicine treatments based on patient genetic profiles.

Prellis Biologics is developing technology to build transplantable human organs and tissues.

AOBiome Therapeutics is a therapeutics company, based in Newton, Massachusetts and founded in 2013, that developed strains of Ammonia Oxidizing Bacteria (AOB) to administer live in treatments that address inflammatory conditions.

A genetics testing company founded in 2013, based in San Francisco.

Locus Biosciences is a biotechnology company developing CRISPR-Cas3-engineered precision antibacterial products.

ViaCyte is a biotechnology company using stem cells to create pancreatic beta cell precursors for treating diabetes.

Massive Bio is a New York-based company founded by Selin Kurnaz, Dr. Arturo Loaiza-Bonilla and Cagatay M. Culcuoglu, offering precision oncology services to cancer patients, providers, and pharmaceutical companies.

A biopharmaceutical company developing therapeutics to attack cancer stem cells.

A company developing anti-aging treatments using components derived from human blood.

Scipher Medicine is a precision immunology company that aims to match patients with their most effective therapy. Their proprietary platform, Spectra, combines AI and a network map of protein interactions in the human body to make predictions.

EpiBone is a biotechnology startup company developing bone reconstruction solutions using stem cells. Nina Tandon, Sarindr Bhumiratana, Gordana Vunjak-Novakovic, and Sidney Eisig founded EpiBone in 2013 and the company is headquartered in New York City, New York.

OrphAI Therapeutics is a biotechnology research company based in Guilford, Connecticut that develops precision therapeutics technology designed to treat cancer and rare diseases.

A medical company in Massachusetts focusing on lowering the cost of vaccine distribution.

Cellink AB is a biotechnology research company based in Gothenburg.

Sherlock Biosciences is a Cambridge, Massachusetts-based company founded in 2019 by David R. Walt, Rahul Dhanda, Feng Zhang, Jim Collins, Deborah Hung, Jonathan Gootenberg, Omar Abudayyeh, Pardis Sabeti and Todd Golub.

Nebula Genomics is a genetics company developing a platform for individuals to get their personal genome sequenced, and then enable them to store and control that information through cryptographic encryption on the blockchain.

Develops novel cell and gene therapies with pharmacologic operating systems.

HelixNano is a Cambridge, Massachusetts-based biotechnology and artificial intelligence company founded in 2013 by Hannu Rajaniemi and Nikolai Eroshenko.

Wild Type is a San Francisco based company producing meat products like salmon using cellular agriculture lab techniques.

Freenome is a San Francisco-based company which uses genetic analysis for early cancer detection and risk assessment.

A therapeutics company founded in 2016 working in drug discovery and development using fungi. LifeMine uses genomics approaches to search for biosynthetic genes in eukaryotic microbes for the discovery of naturally inspired drugs to treat previously untreatable and significant chronic diseases.

GNS Healthcare is a data analytics and healthcare company. It was founded in 2000 and is located in Cambridge, Massachusetts.

Lung Therapeutics is a therapeutics for lung injury and disease company founded in 2013 by Andrew Mazar, Steven Idell and Sreerama Shetty.

A biotechnology company that develops treatments for cancer and hematologic conditions

A bioinformatics company in San Francisco building data collection methods and databases that will enable machine learning algorithms in healthcare. It was founded in 2018.

Ichor Therapeutics is a pre-clinical contract research on aging mechanisms company founded in 2013 by Kelsey Moody.

A biotechnology company developing live attenuated vaccines. It was founded in 2012 and is located in New York.

Eko Health is a digital health and AI technology company developing tools for heart and lung disease detection.

3T Biosciences is a biotechnology company developing immunotherapies.

Company manufacturing 3d printed pharmaceuticals based in San Francisco, CA

Zeteo Tech is a company founded by Charles Call.

DNA synthesis company using enzymatic DNA synthesis based in San Francisco.

Xenex Disinfection Services is a company that provides pulsed xenon ultraviolet-C, room disinfection systems to healthcare facilities

SmartPharm Therapeutics is a Cambridge, MA-based gene therapy company applying the next generation of non-viral DNA and RNA technologies to treat serious human diseases.

Tmunity Therapeutics is a biotechnology company developing t-cell immunotherapies for the treatment of human diseases.

United Launch Alliance is a joint venture of Lockheed Martin and Boeing

Aegle Therapeutics Corporation, a regenerative medicine company isolating extracellular vesicles ("EVs") from allogeneic bone marrow derived mesenchymal stem cells (MSCs) to treat severe dermatological conditions, including burns and epidermolysis bullosa (“EB”).

Allevi, formerly known as BioBots, is a technology company making 3 dimensional bioprinters and bioinks for their printers. The company was founded in 2014 and located in Philadelphia, Pennsylvania.

Sanguine is a company that has the mission to accelerate medical research by eliminating the barriers to patient participation.

Foundation Medicine is a Cambridge, Massachusetts-based pharmaceutical company developing diagnostic and treatment solutions for cancer care founded in 2010 by Alexis Borisy.

64x Bio is a biotechnology company developing a platform for improving speed and scalability of mammalian cell line discovery for pharmaceutical and biotechnology companies.

A biotechnology and industrial automation company. It was founded in 2010 and is located in San Francisco, California.

Genapsys is a company developing DNA sequencing technologies and systems founded in 2010 by Hesaam Esfandyarpour.

Satellite launch, mission management services, and satellite imagery company.

Forcyte Biotechnologies is a Los Angeles-based biotechnology company, founded in 2017.

Protein tests company based in Berkeley founded by Akwasi Apori

Formerly KNOX Medical Diagnostics, Aluna Medical Diagnostics develops respiratory management system for people with chronic lung conditions such as asthma, cystic fibrosis and COPD.

A pharmaceutical company that uses a zebrafish drug-screening platform to find drug candidate molecules that have the capacity to promote regeneration of tissues. Their drug candidate MSI-1436 is being developed and tested for the treatment of heart disease, Duchenne Muscular Dystrophy and diabetic nephropathy.

Verge Genomics is a company focused on the discovery and development of drugs for the treatment of neurodegenerative diseases with the use of machine learning and computational genomics.

CSPA (Computer Science Proficiency Assessment) is a company providing standardized assessment for software engineers. It is located in San Francisco, California and was founded in 2017.The Computer Science Proficiency Assessment (CSPA™) is a comprehensive standardized exam for software engineers.

Tempo Therapeutics is an interventional biomaterials for regenerative medicine company founded by Westbrook Weaver.