69 Best Internal Medicine Startups to Watch in 2025

The Definitive Seedtable Ranking of Internal Medicine Startups

We track 71,000+ companies and rank them dynamically using our Seedtable Score – a score that uses quantitative and qualitative data points to signal the momentum behind a company. We then monitor the list manually leveraging our expertise as founders and investors.

There are 358 start-ups with an aggregate funding of $11.5b. The average funding per company in this subset is $167.0m.

Last update to the database: Feb 18, 2025. See changelog.

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PathAI (company) logo

PathAI (company)

PathAI is a Boston-based artificial intelligence company developing therapeutics and healthcare products.

5

Funding Rounds

$390.0m

Money raised

Tempus Labs (company) logo

Tempus Labs (company)

Tempus, a technology company advancing precision medicine through the practical application of artificial intelligence in healthcare.

10

Funding Rounds

$930.0m

Money raised

Leo Cancer Care logo

Leo Cancer Care

Leo Cancer Care is a company developing upright radiotherapy solutions.

1

Funding Rounds

$25.3m

Money raised

Grail logo

Grail

Grail is a biotechnology company headquartered in Menlo Park, California that was founded as a spinoff of Illumina Inc and initially headed by Jeffrey Huber in 2016, focused on making a medical device that can detect early stage cancer.

4

Funding Rounds

$1.8b

Money raised

Notable Labs logo

Notable Labs

Notable Labs is a company providing personalized drug combination testing service for cancer patients.

8

Funding Rounds

$71.3m

Money raised

Senti Biosciences logo

Senti Biosciences

Senti Biosciences is a synthetic biology company.

2

Funding Rounds

$158.0m

Money raised

Human Longevity Inc. logo

Human Longevity Inc.

Human Longevity is a genomic-based, health intelligence company empowering proactive healthcare and enabling a life better lived.

6

Funding Rounds

$399.8m

Money raised

Flatiron Health logo

Flatiron Health

Flatiron Health is a startup that organizes real-time oncology data to help cancer patients and doctors.

3

Funding Rounds

$313.0m

Money raised

Paige logo

Paige

Paige provides AI-based digital diagnostics and a vendor-neutral platform designed to drive diagnostic confidence and a more productive pathology workflow.

10

Funding Rounds

$410.0m

Money raised

BlueRock Therapeutics logo

BlueRock Therapeutics

A biotechnology company developing engineered cell therapies for treating diseases in neurology, cardiology and autoimmunity.

1

Funding Rounds

$225.0m

Money raised

Kuur Therapeutics logo

Kuur Therapeutics

Kuur Therapeutics focuses on the development of CAR-NKT cell therapies platform for applications in cancer treatment.

6

Funding Rounds

$190.5m

Money raised

AOBiome logo

AOBiome

AOBiome Therapeutics is a therapeutics company, based in Newton, Massachusetts and founded in 2013, that developed strains of Ammonia Oxidizing Bacteria (AOB) to administer live in treatments that address inflammatory conditions.

5

Funding Rounds

$68.7m

Money raised

Spire Health logo

Spire Health

Spire is a company developing tags that provide health tracking including respiration, sleep, stress, activity, and pulse rate.

5

Funding Rounds

$48.1m

Money raised

Massive Bio logo

Massive Bio

Massive Bio is a New York-based company founded by Selin Kurnaz, Dr. Arturo Loaiza-Bonilla and Cagatay M. Culcuoglu, offering precision oncology services to cancer patients, providers, and pharmaceutical companies.

6

Funding Rounds

$15.8m

Money raised

Cell Design Labs logo

Cell Design Labs

A biotechnology company founded in 2015 which operates as a subsidiary of Gilead Sciences and Kite Pharma. The company developed a platform for custom cell engineering called synNotch to be used for anticancer therapies. Their system can also be used to develop cell-based therapies for autoimmune and degenerative disorders.

1

Funding Rounds

$34.4m

Money raised

Stemline Therapeutics logo

Stemline Therapeutics

A biopharmaceutical company developing therapeutics to attack cancer stem cells.

2

Funding Rounds

$13.8m

Money raised

Miragen Therapeutics logo

Miragen Therapeutics

miRagen is a clinical stage biopharmaceutical company developing innovative microRNA-targeting therapies to improve human health.

3

Funding Rounds

$32.0m

Money raised

Prokarium logo

Prokarium

Prokarium is a biopharmaceutical company focused on developing vaccination and cancer immunotherapy solutions based on synthetic biology.

6

Funding Rounds

$86.6m

Money raised

Mission Bio logo

Mission Bio

Mission Bio is a South San Francisco based company that develops single-cell DNA analysis and precision genomics.

4

Funding Rounds

$140.0m

Money raised

Deep Lens logo

Deep Lens

Deep Lens is an Artificial Intelligence company matching patients with clinical trials.

3

Funding Rounds

$31.2m

Money raised

Obsidian Therapeutics logo

Obsidian Therapeutics

Develops novel cell and gene therapies with pharmacologic operating systems.

2

Funding Rounds

$164.5m

Money raised

Freenome logo

Freenome

Freenome is a San Francisco-based company which uses genetic analysis for early cancer detection and risk assessment.

8

Funding Rounds

$967.6m

Money raised

Argos Therapeutics logo

Argos Therapeutics

A company developing immunotherapy treatments for cancers, infectious and autoimmune diseases

2

Funding Rounds

$67.5m

Money raised

Athelas logo

Athelas

Athelas is a company developing blood testing device that utilizes deep learning and computer vision.

5

Funding Rounds

$155.6m

Money raised

Cellerant Therapeutics logo

Cellerant Therapeutics

A biotechnology company that develops treatments for cancer and hematologic conditions

2

Funding Rounds

$18.1m

Money raised

Insitro logo

Insitro

A bioinformatics company in San Francisco building data collection methods and databases that will enable machine learning algorithms in healthcare. It was founded in 2018.

4

Funding Rounds

$743.2m

Money raised

Molecular Stethoscope logo

Molecular Stethoscope

A molecular diagnostics company developing novel blood-based early detection and disease monitoring tests based on analyzing circulating cell-free messenger RNA (cf-mRNA) in blood samples to monitor organ function.

2

Funding Rounds

$13.8m

Money raised

DeVilbiss Healthcare logo

DeVilbiss Healthcare

DeVilbiss Healthcare is a manufacturer of medical devices and products that address the respiratory needs of patients in institutional and home care settings.

1

Funding Rounds

Eko Health logo

Eko Health

Eko Health is a digital health and AI technology company developing tools for heart and lung disease detection.

7

Funding Rounds

$249.0m

Money raised

3T Biosciences logo

3T Biosciences

3T Biosciences is a biotechnology company developing immunotherapies.

3

Funding Rounds

$52.0m

Money raised

Mendel.ai logo

Mendel.ai

Mendel.ai is a life science company offering an artificial intelligence platform to aid clinical experts improve their clinical cancer research.

7

Funding Rounds

$65.4m

Money raised

Oisin Biotechnologies logo

Oisin Biotechnologies

Oisin develops anti-aging treatments that target and remove senescent cells, a type of damaged cell that is unable to divide, accumulates during aging and contribute to age-related diseases.

4

Funding Rounds

$7.1m

Money raised

Owlstone Medical logo

Owlstone Medical

Breathalyzer device maker for the early detection of cancer.

8

Funding Rounds

$160.3m

Money raised

MiRXES logo

MiRXES

MiRXES is a Singapore-based biotechnology company specializing in microRNA-based diagnostics founded in 2014.

1

Funding Rounds

$77.0m

Money raised

Tmunity Therapeutics logo

Tmunity Therapeutics

Tmunity Therapeutics is a biotechnology company developing t-cell immunotherapies for the treatment of human diseases.

5

Funding Rounds

$425.0m

Money raised

Faeth Therapeutics logo

Faeth Therapeutics

Faeth Therapeutics is a start-up that focuses on using nutrition and metabolism to fight cancer.

3

Funding Rounds

$67.0m

Money raised

Aegle Therapeutics logo

Aegle Therapeutics

Aegle Therapeutics Corporation, a regenerative medicine company isolating extracellular vesicles ("EVs") from allogeneic bone marrow derived mesenchymal stem cells (MSCs) to treat severe dermatological conditions, including burns and epidermolysis bullosa (“EB”).

5

Funding Rounds

$14.5m

Money raised

Nucleai logo

Nucleai

An artificial intelligence company with a focus on developing solutions for the healthcare industry. It was founded in 2017 and is located in Tel Aviv, Israel.

2

Funding Rounds

$11.5m

Money raised

Sanguine (company) logo

Sanguine (company)

Sanguine is a company that has the mission to accelerate medical research by eliminating the barriers to patient participation.

1

Funding Rounds

$1.0m

Money raised

Foundation Medicine logo

Foundation Medicine

Foundation Medicine is a Cambridge, Massachusetts-based pharmaceutical company developing diagnostic and treatment solutions for cancer care founded in 2010 by Alexis Borisy.

4

Funding Rounds

$96.5m

Money raised

ALung Technologies logo

ALung Technologies

A medical device company for patients with respiratory failure. Developing the Hemolung Respiratory Assist System (RAS), a dialysis-like alternative or supplement to mechanical ventilation.

3

Funding Rounds

$60.0m

Money raised

CaroGen logo

CaroGen

CaroGen is an immunotherapy company that develops vaccine candidates that target hepatitis B and C, as well as other viral agents.

1

Funding Rounds

$150.0k

Money raised

OncoSenX logo

OncoSenX

OncoSenX is a spinout company of Oisin Biotechnologies, formed to develop programmable suicide gene therapy to kill cancerous cells.

5

Funding Rounds

$19.7m

Money raised

ITM Isotopen Technologien Munchen logo

ITM Isotopen Technologien Munchen

ITM Isotopen Technologien Munchen is a Munich-based developer of personalized cancer diagnostic solutions.

2

Funding Rounds

$58.4m

Money raised

Odyssey Therapeutics logo

Odyssey Therapeutics

Focused on transforming lives of patients with immune dysfunctions and cancer

2

Funding Rounds

$386.0m

Money raised

HeartFlow logo

HeartFlow

HeartFlow is a company developing non-invasive cardiovascular disease detection technology.

9

Funding Rounds

$807.7m

Money raised

Stelvio Therapeutics logo

Stelvio Therapeutics

Stelvio Therapeutics is a biotechnology company developing therapeutics for cancer.

1

Funding Rounds

Stem Cell Theranostics logo

Stem Cell Theranostics

A biotechnology company founded in 2013 that develops technology to treat heart disease using pluripotent stem cells. Disease in a dish and clinical trial in a dish platforms are used to develop cardiovascular drugs and perform cardio-toxicity safety testing for non-cardiovascular drugs.

1

Funding Rounds

$5.5m

Money raised

Snipr Biome logo

Snipr Biome

Snipr Biome is a synthetic biology company using CRISPR to make products for the microbiome.

2

Funding Rounds

$100.0m

Money raised

Azitra logo

Azitra

A company based in Farmington, Connecticut, that develops skin disease treatments using microbiome science and technology.

9

Funding Rounds

$56.6m

Money raised

EpiVax (company) logo

EpiVax (company)

A computational immunology and vaccine development company based in Providence, Rhode Island. It was founded in 1998.

9

Funding Rounds

$4.3m

Money raised

DCPrime logo

DCPrime

DCPrime is a biotechnology company developing cancer immunotherapies.

5

Funding Rounds

$26.0m

Money raised

JW (Cayman) Therapeutics Co. Ltd logo

JW (Cayman) Therapeutics Co. Ltd

JW (Cayman) Therapeutics Co. Ltd is a Shanghai-based developer of cell-based therapy technologies for cancer treatment.

2

Funding Rounds

$195.5m

Money raised

iOx Therapeutics Limited logo

iOx Therapeutics Limited

Biotechnology company founded in 2015 that develops and commercializes synthetic lipid compounds and cancer immunotherapy agents. iOx Therapeutics is an OSI spinout.

1

Funding Rounds

A&G Pharmaceutical logo

A&G Pharmaceutical

A&G Pharmaceutical is a Columbia, Maryland-based theranostics company developing personalized cancer therapeutics through cancer-specific monoclonal antibodies.

1

Funding Rounds

$2.0m

Money raised

Scioderm logo

Scioderm

A pharmaceutical company that develops topical products to treat rare diseases

1

Funding Rounds

$16.0m

Money raised

resTORbio logo

resTORbio

A biopharmaceutical company developing therapeutics for treating age-related diseases.

3

Funding Rounds

$105.0m

Money raised

Eureka Therapeutics, Inc logo

Eureka Therapeutics, Inc

Eureka Therapeutics is a biotechnology company developing immunotherapies for the treatment of cancer.

2

Funding Rounds

$105.0m

Money raised

Iconic Therapeutics logo

Iconic Therapeutics

A pharmaceutical company developing tissue factor therapies for the treatment of cancer and diseases.

3

Funding Rounds

$32.5m

Money raised

Epic Sciences logo

Epic Sciences

Epic Sciences is a San Diego-based company founded in 2008 by Jorge Nieva, David Nelson and Peter Kuhn.

7

Funding Rounds

$195.5m

Money raised

Promega logo

Promega

Promega is a Madison, Wisconsin-based biotechnology company developing products for research, drug discovery, forensics, paternity testing, and diagnostic applications.

1

Funding Rounds

Gadeta logo

Gadeta

Gadeta is a biotechnology company developing immunotherapies for treating cancer.

1

Funding Rounds

$7.0m

Money raised

Soteria Biotherapeutics logo

Soteria Biotherapeutics

Soteria Biotherapeutics is a biotechnology company developing cancer immunotherapies.

1

Funding Rounds

$42.2m

Money raised

AliveCor logo

AliveCor

AliveCor is a San Francisco-based company developing AI-based ECG technologies.

6

Funding Rounds

$117.7m

Money raised

Scorpion Therapeutics logo

Scorpion Therapeutics

Small Molecules

4

Funding Rounds

$270.0m

Money raised

Kheiron Medical Technologies logo

Kheiron Medical Technologies

Biomedical Artificial Intelligence company developing products for early cancer detection in the breast.

1

Funding Rounds

$22.0m

Money raised

Moving Analytics logo

Moving Analytics

Moving Analytics is developing a virtual care management software for cardiac rehab.

3

Funding Rounds

$26.9m

Money raised

Kernal Biologics logo

Kernal Biologics

Cambridge, MA-based company developing targeted mRNA therapeutics for cancer and other diseases.

3

Funding Rounds

$50.6m

Money raised

IRX Therapeutics logo

IRX Therapeutics

A company developing immune therapies for cancer and related diseases

2

Funding Rounds

$33.8m

Money raised