69 Best Engineering Startups to Watch in 2025

Synthace is a software company based out of London, UK, building automation software that gives biologists the ability to control and analyze the performance of lab hardware.

Mammoth Biosciences is an American company based in San Francisco founded on June 1, 2017. Mammoth Biosciences uses CRISPR technology to develop bio-sensing technologies for diagnostics in industries such as healthcare, agriculture, manufacturing, and forensics and genome editing therapeutics.

Arzeda is a biotechnology and software company designing custom microorganisms for industrial applications through computational enzyme design, protein optimization, and metabolic engineering.

A genetic medicine company that build data platforms using synthetic biology, artificial intelligence and genetic medicine for the development of medical therapies.

Company developing space manufacturing technologies to support exploration, national security, and sustainable space settlement.

Indee Labs focuses on the development of microfluidic vortex shedding for rapidly and efficiently transfecting human primary immune cells with negligible perturbation. The team is focused on developing its core technology for short turnaround chimeric antigen receptor T cell (CAR-T) development and manufacturing.

Owkin is a medical treatment and therapeutics company founded by Thomas Clozel. They develop artificial intelligence and machine learning tools to augment and develop medical and biological research.

Insilico Medicine is a drug discovery, artificial intelligence company that looks to treat cancer and age related diseases

Tempus, a technology company advancing precision medicine through the practical application of artificial intelligence in healthcare.

Finless Foods is a biotechnology company producing cultured marine animal food products through implementing cellular agriculture and manufacturing technologies.

Molecular Assemblies, Inc. is an enzymatic DNA synthesis technology founded in 2013 by Curt Becker, Bill Efcavitch and William Efcavitch.

An Israeli startup company that is working to make sustainable "animal-free" cell-based meat products available at the local level by adapting the distributed manufacturing model

Aleph Farms is an Israeli cellular agriculture start-up founded by Didier Toubia and Shulamit Levenberg in 2017 developing technologies for culturing meat products into 3D structures.

Mount Sinai Genomics is a Connecticut-based medical genetics practice at the Mount Sinai Health System.

Upside Foods is a San Francisco-based company making cultured meat products. The company was founded by Uma Valeti, Nicholas Genovese, and Will Clem.

Grail is a biotechnology company headquartered in Menlo Park, California that was founded as a spinoff of Illumina Inc and initially headed by Jeffrey Huber in 2016, focused on making a medical device that can detect early stage cancer.

Catalog is a Boston, Massachusetts-based company developing a platform for DNA-based digital data storage.

Lucigen is a biotechnology company offering research and testing products and services to life science professionals. The company was founded in 1998, and is headquartered in Middleton, Wisconsin.

Paradromics is an Austin, Texas-based company developing a high-volume bidirectional data streaming capabilities between brains and computers.

Chai Biotechnologies (also known as Chai and Chai Bio) is a biotechnology company building real-time PCR, qPCR and devices that detect pathogens, speciate meat and genotype DNA.

Synchron, Inc. is a technology company building implantable neural interface solutions, including endovascular brain-computer interface.

Notable Labs is a company providing personalized drug combination testing service for cancer patients.

A diagnostic DNA testing company using quantified biological data.

Aria Pharmaceuticals is a first-in-class pharmaceutical discovery and development founded in 2014 by Andrew M. Radin.

Senti Biosciences is a synthetic biology company.

Human Longevity is a genomic-based, health intelligence company empowering proactive healthcare and enabling a life better lived.

Genomatica is a San Diego-based company founded in 2000 by Christophe Schilling.

A cellular agriculture company making fresh and frozen cultured seafood products.

Orbit Discovery offers a DNA-encoded peptide display technology to identify potential peptide drugs for a range of chronic diseases.

BGI is a life science and genomics organization following a development model of research, production and application.

Meatable is a cellular agriculture company making 100 percent clean meat products.

Paige provides AI-based digital diagnostics and a vendor-neutral platform designed to drive diagnostic confidence and a more productive pathology workflow.

A biotechnology company that develops medicines based on live bacterial consortia that can colonize the human intestine.

RoosterBio is a biotechnology company located in Frederick, Maryland, founded by Jon Rowley in 2013 providing standardized stem cell products for R&D, clinical, and commercial use in the regenerative medicine industry.

Orig3n is a biotechnology company developing personalized regenerative medicine treatments based on patient genetic profiles.

Mosa Meat is a Dutch start-up company that makes and commercializes clean meat, meat made by growing animal cells directly rather than slaughtering animals.

Integriculture is a Japanese cellular agriculture company making lab grown foie gras and other clean meat and cellular agriculture products. The company was founded in on October 23, 2015 and is located in Tokyo, Japan.

An industrial biotech company developing a commercial bioprocess for manufacturing bio-based malonic acid.

Scribe Therapeutics develops molecular engineering solutions for CRISPR-based genetic medicine.

Prellis Biologics is developing technology to build transplantable human organs and tissues.

Cala Health offers bioelectronic medicines, medical devices, and neurotherapeutics for managing chronic health conditions.

Kuur Therapeutics focuses on the development of CAR-NKT cell therapies platform for applications in cancer treatment.

AOBiome Therapeutics is a therapeutics company, based in Newton, Massachusetts and founded in 2013, that developed strains of Ammonia Oxidizing Bacteria (AOB) to administer live in treatments that address inflammatory conditions.

A-Alpha Bio is a startup that has built a platform technology and aims to speed up the development of new drugs.

A genetics testing company founded in 2013, based in San Francisco.

Locus Biosciences is a biotechnology company developing CRISPR-Cas3-engineered precision antibacterial products.

Promethera Biosciences is a biotechnology company developing regenerative medicine treatments for liver diseases.

ViaCyte is a biotechnology company using stem cells to create pancreatic beta cell precursors for treating diabetes.

Massive Bio is a New York-based company founded by Selin Kurnaz, Dr. Arturo Loaiza-Bonilla and Cagatay M. Culcuoglu, offering precision oncology services to cancer patients, providers, and pharmaceutical companies.

Biotherapeautics company founded in 2014 and based in Paris that uses proprietary methods in synthetic biology, protein and genome engineering to produce Eligobiotics, products which intervene with the microbiome as diagnostics, antimicrobials and modulators of host-microbiome interactions.

A biopharmaceutical company developing therapeutics to attack cancer stem cells.

Empatica designs and develops wearable health devices for health monitoring, treatment, and research.

SuperMeat is an Israeli biotechnology company, founded on December 15, 2015. SuperMeat is working to develop chicken meat products cultured from extracted chicken cells.

Uncommon, formerly known as Higher Steaks, is a cellular agriculture company based in London, England founded in 2017 by Benjamina Bollag, Stephanie Wallis and David Hay working to develop pork and other meat products using cellular agriculture.

Nanomedicine company developing vaccines and therapies with cell-specific targeting.

William George Zane Jr. is an American actor, producer, and artist. His breakthrough role was in the 1989 Australian film Dead Calm, a performance that earned him a nomination for the Chicago Film Critics Association Award for Most Promising Actor.

Synthetic biology company that uses AI, DNA synthesis, and robotics to discover biological molecules.

Scipher Medicine is a precision immunology company that aims to match patients with their most effective therapy. Their proprietary platform, Spectra, combines AI and a network map of protein interactions in the human body to make predictions.

EpiBone is a biotechnology startup company developing bone reconstruction solutions using stem cells. Nina Tandon, Sarindr Bhumiratana, Gordana Vunjak-Novakovic, and Sidney Eisig founded EpiBone in 2013 and the company is headquartered in New York City, New York.

OrphAI Therapeutics is a biotechnology research company based in Guilford, Connecticut that develops precision therapeutics technology designed to treat cancer and rare diseases.

Prokarium is a biopharmaceutical company focused on developing vaccination and cancer immunotherapy solutions based on synthetic biology.

A medical company in Massachusetts focusing on lowering the cost of vaccine distribution.

Silicon Valley-based genetic engineering startup.

An exosome therapeutics company founded in 2016 and based in Oxford, UK, that uses exosomes to deliver small and large molecule therapeutics. The company has a proprietary technology to modify exosomes to target specific organs such as the brain and central nervous system.

Metabolon is a company developing metabolomics analytical methods and software for biomarker discovery

Cellink AB is a biotechnology research company based in Gothenburg.

Envisagenics is a biotechnology company founded by Maria Luisa Pineda and Martin Akerman in 2014 and headquartered in New York City, New York using artificial intelligence and RNA sequencing to develop therapeutics to treat genetic diseases.

Mission Bio is a South San Francisco based company that develops single-cell DNA analysis and precision genomics.

Shiok Meats is a Singapore-based cellular agriculture company focusing on making cultured seafood.