69 Best Startups in Waltham Massachusetts to Watch in 2025

The Definitive Seedtable Ranking of Startups in Waltham Massachusetts

We track 71,000+ companies and rank them dynamically using our Seedtable Score – a score that uses quantitative and qualitative data points to signal the momentum behind a company. We then monitor the list manually leveraging our expertise as founders and investors.

There are 143 start-ups with an aggregate funding of $6.5b. The average funding per company in this subset is $94.2m.

Last update to the database: Feb 18, 2025. See changelog.

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2

Funding Rounds

$192.0m

Money raised

Scipher Medicine is a precision immunology company that aims to match patients with their most effective therapy. Their proprietary platform, Spectra, combines AI and a network map of protein interactions in the human body to make predictions.

5

Funding Rounds

$217.0m

Money raised

Takeoff Technologies provides an automated grocery fulfillment solution for grocers.

1

Funding Rounds

$1.0m

Money raised

Sanguine is a company that has the mission to accelerate medical research by eliminating the barriers to patient participation.

7

Funding Rounds

$62.8m

Money raised

A Boston-based emotion measurement technology company developing computer vision, machine learning, and deep learning technology.

7

Funding Rounds

$120.1m

Money raised

A company in Israel that develops signal-processing technology and offers EverOn, a contact-free and early detection patient supervision system.

3

Funding Rounds

$90.2m

Money raised

Chiasma Pharma is a Waltham, Massachusetts-based biopharmaceutical company developing oral drugs for the treatment of orphan diseases.

3

Funding Rounds

$55.0m

Money raised

A logistics company that uses technology to fulfill warehouse orders. It was founded in 2015 and is located in Waltham, Massachusetts.

4

Funding Rounds

$226.0m

Money raised

Arrakis is developing RNA-targeted small molecule (rSM) therapies to millions of patients.

3

Funding Rounds

$53.5m

Money raised

A company developing and commercializing cancer molecular diagnostics based isolation of exosomes from body fluids. Exosome Diagnostics was founded in 2008.

7

Funding Rounds

$24.6m

Money raised

Jazz is a company founded in 2009 by Don Charlton.

6

Funding Rounds

$116.0m

Money raised

Axial Therapeutics is a biopharmaceutical company targeting neurological disorders such as Parkinson's and Autism via gut health.

5

Funding Rounds

$80.2m

Money raised

Humantics is a software company that was founded in 2015.

3

Funding Rounds

$1.5b

Money raised

Devoted Health is a healthcare company serving seniors.

14

Funding Rounds

$293.9m

Money raised

Avedro is a company that is advancing the field of Corneal Remodeling.

5

Funding Rounds

$207.5m

Money raised

Actifio is a company developing enterprise data-as-a-service.

4

Funding Rounds

$22.6m

Money raised

GreatHorn is a Waltham, Massachusetts-based cybersecurity company developing protection products for cloud email systems.

1

Funding Rounds

$7.5m

Money raised

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Industries:

Key people:

6

Funding Rounds

$46.4m

Money raised

Novomer is a Waltham, Massachusetts-based company founded in 2004 by Scott D. Allen.

9

Funding Rounds

$107.6m

Money raised

BG Medicine is a company developing diagnostic products for heart failure and related disorders.

8

Funding Rounds

$113.7m

Money raised

Minerva Biotechnologies is a clinical-stage biopharmaceutical company focused on developing immunotherapies for solid tumor cancers and cellular therapies for regenerative medicine.

2

Funding Rounds

$97.0m

Money raised

Immuitas Therapeutics is a company using immunology for complex cancer treatment.

5

Funding Rounds

$55.9m

Money raised

MetaMark Genetics is a medical diagnostics company developing tests and treatment planning for cancer patients.

3

Funding Rounds

$45.0m

Money raised

CyberX was a Waltham, Massachusetts-based cybersecurity company. The company was acquired by Microsoft in June 2020.

4

Funding Rounds

$143.0m

Money raised

Vecna Robotics is a robotics and tech company based in the United States and is a spin-off from Vecna Technologies.

Key people:

2

Funding Rounds

$5.3m

Money raised

Allure provide Behavioral Analytics software that combines machine learning and decoy technology to protect enterprise devices from data loss and intrusion both inside and outside the enterprise.

6

Funding Rounds

$158.5m

Money raised

Company

6

Funding Rounds

$19.4m

Money raised

Tego is a Waltham, Massachusetts-based company founded by Timothy Butler, Bob Hamlin and Suhail Ahmad.

1

Funding Rounds

$7.3m

Money raised

Findaility Sciences is an artificial intelligence information technology company that was founded in 2010.

2

Funding Rounds

$18.0m

Money raised

Ultimaker is a dutch 3d printer manufacturer founded in 2011 by Siert Wijnia, Erik de Bruijn and Martijn Elserman.

3

Funding Rounds

$23.0m

Money raised

InnoCentive is a Waltham, Massachusetts-based company founded in 2001.

1

Funding Rounds

$8.8m

Money raised

Respirator Depression Monitor

3

Funding Rounds

$33.0m

Money raised

Yottaa is an eCommerce acceleration platform that enables online brands to improve web performance and increase online conversion.

2

Funding Rounds

$80.0m

Money raised

Uptycs is a Waltham, Massachusetts-based computer security company.

3

Funding Rounds

$28.0m

Money raised

Veo Robotics is a Waltham, Massachusetts-based company.

3

Funding Rounds

$21.0m

Money raised

CallMiner is a Waltham, Massachusetts-based company founded in 2002.

2

Funding Rounds

$33.5m

Money raised

Instylla is a Waltham, Massachusetts-based diagnostic tools company developing solutions for embolization and founded in 2017 by Amarpreet Sawhney.

6

Funding Rounds

$80.7m

Money raised

InfoBionic is an arrhythmia detection and monitoring founded in 2011 by Nancy Briefs, Jeremy Ruskin and Ravi Kuppuraj.

2

Funding Rounds

$695.0m

Money raised

ElevateBio is a company founded by Vikas Sinha, David Hallal and Melissa Carpenter.

7

Funding Rounds

$133.7m

Money raised

Corindus Vascular Robotics is a Siemens healthineers company and a leader in robotic-assisted vascular interventions.

2

Funding Rounds

$43.0m

Money raised

A genomics company offering clinically guided personal genetic testing service

8

Funding Rounds

$2.0m

Money raised

Dynamic Ideas is a company which publishes technical books through Dynamic ideas Publishing and offers transportation management tools through Dynamic Ideas Routing. The company offers AI and analytics consulting and products as well

2

Funding Rounds

$23.9m

Money raised

Imprivata is an it security company founded in 2002.

1

Funding Rounds

$95.0m

Money raised

Infinidat is a company developing, manufacturing and providing data storage and protection devices.

4

Funding Rounds

$27.4m

Money raised

SavingStar is a Waltham, Massachusetts-based company.

2

Funding Rounds

$38.7m

Money raised

Building Engines is a company founded in 2000 by Alex Rangel.

3

Funding Rounds

$47.0m

Money raised

OvaScience is a fertility biotechnology company

2

Funding Rounds

$147.6m

Money raised

Palleon Pharmaceuticals is a glycoimmune Checkpoint Inhibitors founded in 2016.

5

Funding Rounds

$111.6m

Money raised

ANDE is a rapid DNA Analysis founded by Richard Selden.

2

Funding Rounds

$20.9m

Money raised

Brainshark is a Waltham, Massachusetts-based company founded in 2005.

1

Funding Rounds

$55.0m

Money raised

Linus Health is a company founded in 2019.

2

Funding Rounds

$48.0m

Money raised

Skyhawk Therapeutics is a RNA-correcting Small Molecules founded in 2016 by Bill Haney.

1

Funding Rounds

$1.3m

Money raised

Hemera Biosciences is a treatment for dry macular degeneration company founded in 2010 by Jay S. Duker, Elias Reichel and Adam Rogers.

2

Funding Rounds

$25.2m

Money raised

CloudLock is a Waltham, Massachusetts-based cybersecurity and cloud security company developing solutions for cloud-based data.

2

Funding Rounds

$7.0m

Money raised

Thermedical is a medical device company developing Thermedical Ablation System founded by Michael G. Curley.

4

Funding Rounds

$5.1m

Money raised

Benefits Science is a data science and technology company.

3

Funding Rounds

$300.0m

Money raised

Small Molecules targeting proteins in the inflammasome and nucleic acid sensing signaling pathways

1

Funding Rounds

$1.0m

Money raised

Kinderlab Robotics develops and provides educational STEM robot learning kits for children.

2

Funding Rounds

$1.6m

Money raised

Mobiquity Inc. is a Waltham, Massachusets-based consulting company designing cloud-based digital products and services.

2

Funding Rounds

$23.0m

Money raised

PerkinElmer Informatics is a company developing enterprise software solutions for the development of biological products and treatments. The company was known as CambridgeSoft until it was acquired by PerkinElmer in 2011.

2

Funding Rounds

$63.2m

Money raised

Spectrawave is a medical device company that develops optical diagnostic and therapeutic devices.

3

Funding Rounds

$55.5m

Money raised

Adnexus Therapeutics is a company founded by Noubar Afeyan.

1

Funding Rounds

$4.0m

Money raised

A biotechnology company focused on developing covalent drugs for the treatment of cancer and other autoimmune diseases

1

Funding Rounds

$9.8m

Money raised

Randori is an attack platform that provides "red-teaming" as a service -- basically, staging simulated hack attacks to test for vulnerabilities and gaps in the security response.

1

Funding Rounds

$353.0k

Money raised

Intelligent Bio-Systems, Inc. is a DNA sequencing developing company.

1

Funding Rounds

$40.0m

Money raised

Ranok Therapeutics uses of chaperone-mediated protein degraders (CHAMPs) against BRD4, a transcription factor that is implicated in cancer development.

Industries:

Location:

2

Funding Rounds

$54.0m

Money raised

Nocion Therapeutics is developing positively charged versions of "caines" -- broadly acting intracellular sodium channel blockers

1

Funding Rounds

$5.6m

Money raised

Education Development Center is a Waltham, Massachusetts-based company founded in 1958.

1

Funding Rounds

$200.0k

Money raised

MindEdge is an online learning platform which provides solutions for leadership, management, communication, and education.

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