69 Best Therapeutics Startups to Watch in 2025

The Definitive Seedtable Ranking of Therapeutics Startups

We track 71,000+ companies and rank them dynamically using our Seedtable Score – a score that uses quantitative and qualitative data points to signal the momentum behind a company. We then monitor the list manually leveraging our expertise as founders and investors.

There are 408 start-ups with an aggregate funding of $8.5b. The average funding per company in this subset is $122.5m.

Last update to the database: Feb 18, 2025. See changelog.

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Bolt Threads logo

Bolt Threads

Bolt Threads is a biotechnology company that makes high performance fabrics and materials using biology.

8

Funding Rounds

$406.4m

Money raised

Insilico Medicine logo

Insilico Medicine

Insilico Medicine is a drug discovery, artificial intelligence company that looks to treat cancer and age related diseases

6

Funding Rounds

$356.3m

Money raised

Notable Labs logo

Notable Labs

Notable Labs is a company providing personalized drug combination testing service for cancer patients.

8

Funding Rounds

$71.3m

Money raised

Senti Biosciences logo

Senti Biosciences

Senti Biosciences is a synthetic biology company.

2

Funding Rounds

$158.0m

Money raised

Human Longevity Inc. logo

Human Longevity Inc.

Human Longevity is a genomic-based, health intelligence company empowering proactive healthcare and enabling a life better lived.

6

Funding Rounds

$399.8m

Money raised

Genomatica logo

Genomatica

Genomatica is a San Diego-based company founded in 2000 by Christophe Schilling.

10

Funding Rounds

$635.4m

Money raised

Orbit Discovery logo

Orbit Discovery

Orbit Discovery offers a DNA-encoded peptide display technology to identify potential peptide drugs for a range of chronic diseases.

2

Funding Rounds

$16.8m

Money raised

Visterra logo

Visterra

A company developing antibody-based biological medicines for kidney diseases and other chronic diseases. Visterra was acquired by Otsuka Pharmaceutical in 2018.

4

Funding Rounds

$153.7m

Money raised

BlueRock Therapeutics logo

BlueRock Therapeutics

A biotechnology company developing engineered cell therapies for treating diseases in neurology, cardiology and autoimmunity.

1

Funding Rounds

$225.0m

Money raised

Vedanta Biosciences logo

Vedanta Biosciences

A biotechnology company that develops medicines based on live bacterial consortia that can colonize the human intestine.

13

Funding Rounds

$386.6m

Money raised

Lygos logo

Lygos

An industrial biotech company developing a commercial bioprocess for manufacturing bio-based malonic acid.

11

Funding Rounds

$50.0m

Money raised

Scribe Therapeutics logo

Scribe Therapeutics

Scribe Therapeutics develops molecular engineering solutions for CRISPR-based genetic medicine.

2

Funding Rounds

$120.0m

Money raised

Neos Therapeutics logo

Neos Therapeutics

Neos Therapeutics is a pharmaceutical company developing ADHD medications founded in 2008.

1

Funding Rounds

$24.1m

Money raised

AOBiome logo

AOBiome

AOBiome Therapeutics is a therapeutics company, based in Newton, Massachusetts and founded in 2013, that developed strains of Ammonia Oxidizing Bacteria (AOB) to administer live in treatments that address inflammatory conditions.

5

Funding Rounds

$68.7m

Money raised

Locus Biosciences logo

Locus Biosciences

Locus Biosciences is a biotechnology company developing CRISPR-Cas3-engineered precision antibacterial products.

8

Funding Rounds

$117.5m

Money raised

Eligo Bioscience logo

Eligo Bioscience

Biotherapeautics company founded in 2014 and based in Paris that uses proprietary methods in synthetic biology, protein and genome engineering to produce Eligobiotics, products which intervene with the microbiome as diagnostics, antimicrobials and modulators of host-microbiome interactions.

9

Funding Rounds

$82.6m

Money raised

Cell Design Labs logo

Cell Design Labs

A biotechnology company founded in 2015 which operates as a subsidiary of Gilead Sciences and Kite Pharma. The company developed a platform for custom cell engineering called synNotch to be used for anticancer therapies. Their system can also be used to develop cell-based therapies for autoimmune and degenerative disorders.

1

Funding Rounds

$34.4m

Money raised

Stemline Therapeutics logo

Stemline Therapeutics

A biopharmaceutical company developing therapeutics to attack cancer stem cells.

2

Funding Rounds

$13.8m

Money raised

Miragen Therapeutics logo

Miragen Therapeutics

miRagen is a clinical stage biopharmaceutical company developing innovative microRNA-targeting therapies to improve human health.

3

Funding Rounds

$32.0m

Money raised

Alkahest logo

Alkahest

A company developing anti-aging treatments using components derived from human blood.

3

Funding Rounds

$41.0m

Money raised

EpiBone logo

EpiBone

EpiBone is a biotechnology startup company developing bone reconstruction solutions using stem cells. Nina Tandon, Sarindr Bhumiratana, Gordana Vunjak-Novakovic, and Sidney Eisig founded EpiBone in 2013 and the company is headquartered in New York City, New York.

1

Funding Rounds

ApexQubit logo

ApexQubit

ApexQubit is a biotechnology company that is harnessing a proprietary technology for discovery of new medicines to treat patients with undruggable diseases.

3

Funding Rounds

$54.1k

Money raised

Evox Therapeutics logo

Evox Therapeutics

An exosome therapeutics company founded in 2016 and based in Oxford, UK, that uses exosomes to deliver small and large molecule therapeutics. The company has a proprietary technology to modify exosomes to target specific organs such as the brain and central nervous system.

3

Funding Rounds

$143.4m

Money raised

Emerald Therapeutics logo

Emerald Therapeutics

Emerald Therapeutics is a biotechnology company located in San Fransisco, California, founded by Brian Frezza and DJ Klienbaum in 2010. Emerald Therapeutics offers cloud a based software and hardware platform that allows researchers to remotely perform automated scientific laboratory experiments.

2

Funding Rounds

$22.8m

Money raised

LanzaTech logo

LanzaTech

A New Zealand industrial biotechnology company developing a gas fermentation platform for converting concentrated industrial emissions into valuable chemicals.

6

Funding Rounds

$265.4m

Money raised

Envisagenics logo

Envisagenics

Envisagenics is a biotechnology company founded by Maria Luisa Pineda and Martin Akerman in 2014 and headquartered in New York City, New York using artificial intelligence and RNA sequencing to develop therapeutics to treat genetic diseases.

9

Funding Rounds

$26.8m

Money raised

Alzheon logo

Alzheon

Develops medicines for patients suffering from Alzheimer's disease and other neurological disorders.

8

Funding Rounds

$92.7m

Money raised

Obsidian Therapeutics logo

Obsidian Therapeutics

Develops novel cell and gene therapies with pharmacologic operating systems.

2

Funding Rounds

$164.5m

Money raised

Argos Therapeutics logo

Argos Therapeutics

A company developing immunotherapy treatments for cancers, infectious and autoimmune diseases

2

Funding Rounds

$67.5m

Money raised

LifeMine Therapeutics logo

LifeMine Therapeutics

A therapeutics company founded in 2016 working in drug discovery and development using fungi. LifeMine uses genomics approaches to search for biosynthetic genes in eukaryotic microbes for the discovery of naturally inspired drugs to treat previously untreatable and significant chronic diseases.

3

Funding Rounds

$280.0m

Money raised

Lung Therapeutics logo

Lung Therapeutics

Lung Therapeutics is a therapeutics for lung injury and disease company founded in 2013 by Andrew Mazar, Steven Idell and Sreerama Shetty.

2

Funding Rounds

$50.3m

Money raised

Cellerant Therapeutics logo

Cellerant Therapeutics

A biotechnology company that develops treatments for cancer and hematologic conditions

2

Funding Rounds

$18.1m

Money raised

Insitro logo

Insitro

A bioinformatics company in San Francisco building data collection methods and databases that will enable machine learning algorithms in healthcare. It was founded in 2018.

4

Funding Rounds

$743.2m

Money raised

Ichor Therapeutics logo

Ichor Therapeutics

Ichor Therapeutics is a pre-clinical contract research on aging mechanisms company founded in 2013 by Kelsey Moody.

5

Funding Rounds

$2.5m

Money raised

Nextbiotics logo

Nextbiotics

Nextbiotics is a biotechnology and synthetic biology company that leverages synthetic biology tools and bacteriophage technology to provide solutions to the antibiotic resistance crisis.

1

Funding Rounds

$750.0k

Money raised

Aetion logo

Aetion

Leader in delivering real-world evidence (RWE) and outcomes-based analytics solutions to life science companies and payers.

6

Funding Rounds

$230.6m

Money raised

Rodin Therapeutics logo

Rodin Therapeutics

Rodin Therapeutics was a biotechnology company that developed treatments for Alzheimer's disease. Founded in 2013, it was acquired in 2019 by Alkermes.

3

Funding Rounds

$39.9m

Money raised

Betalin Therapeutics logo

Betalin Therapeutics

Biological micro-pancreas for insulin-dependent diabetics company

4

Funding Rounds

$5.1m

Money raised

Oisin Biotechnologies logo

Oisin Biotechnologies

Oisin develops anti-aging treatments that target and remove senescent cells, a type of damaged cell that is unable to divide, accumulates during aging and contribute to age-related diseases.

4

Funding Rounds

$7.1m

Money raised

Dyno Therapeutics logo

Dyno Therapeutics

Dyno Therapeutics is a company based in Cambridge, Massachusetts applying artificial intelligence to gene therapy, focused on adeno-associated virus capsid engineering.

3

Funding Rounds

$109.0m

Money raised

Antera Therapeutics logo

Antera Therapeutics

Antera Therapeutics is an allergy prevention development company.

2

Funding Rounds

$2.0m

Money raised

SWORD Health logo

SWORD Health

SWORD Health is a digital therapy provider for pain.

12

Funding Rounds

$576.4m

Money raised

ImStar Therapeutics logo

ImStar Therapeutics

ImStar Therapeutics is company developing treatments for ALS, dementia, and other neurodegenerative diseases.

1

Funding Rounds

$1.8m

Money raised

Peptone logo

Peptone

Peptome is a London-based protein physics intelligence company founded in 2016 by Kamil Tamiola and Matt Heberling. It utilizes artificial intelligence for computers to process all information about protein data in the same efficient way that scientists do.

5

Funding Rounds

$82.8m

Money raised

Faeth Therapeutics logo

Faeth Therapeutics

Faeth Therapeutics is a start-up that focuses on using nutrition and metabolism to fight cancer.

3

Funding Rounds

$67.0m

Money raised

Palvella Therapeutics, Inc. logo

Palvella Therapeutics, Inc.

Palvella Therapeutics is committed to developing safe and effective therapies that specifically target the root cause of genetic skin diseases.

2

Funding Rounds

$55.0m

Money raised

Aegle Therapeutics logo

Aegle Therapeutics

Aegle Therapeutics Corporation, a regenerative medicine company isolating extracellular vesicles ("EVs") from allogeneic bone marrow derived mesenchymal stem cells (MSCs) to treat severe dermatological conditions, including burns and epidermolysis bullosa (“EB”).

5

Funding Rounds

$14.5m

Money raised

OMass Therapeutics logo

OMass Therapeutics

A biotechnology company using mass spectrometry platforms for drug discovery and the development of therapeutics.

1

Funding Rounds

$100.0m

Money raised

Juventus Therapeutics logo

Juventus Therapeutics

Juventas Therapeutics is a biotechnology company founded in 2007 that is headquartered in Cleveland, Ohio developing a pipeline of regenerative therapies to treat life-threatening diseases.

4

Funding Rounds

$46.7m

Money raised

CHAIN Biotechnology logo

CHAIN Biotechnology

CHAIN Biotechnology is a live biotherapeutics company founded in 2014 and based in Nottingham and Marlow, UK. CHAIN works with the Synthetic Biology Research Centre in Nottingham and has built a live biotherapeutic platform based on Clostridia to deliver bioactive molecules to treat diseases associated with the human gut microbiome.

2

Funding Rounds

$645.0k

Money raised

YourChoice Therapeutics logo

YourChoice Therapeutics

YourChoice Therapeutics is a biotechnology company founded in 2018 is developing contraceptives for men and women. The technology for their non-hormonal contraceptive products arose from research at the University of California, Berkeley.

4

Funding Rounds

$16.8m

Money raised

Biofourmis logo

Biofourmis

Biofourmis is a global health IT start-up in Massachusetts that focuses on personalized care and therapies using digital therapeutics.

7

Funding Rounds

$443.5m

Money raised

Hyperion Therapeutics logo

Hyperion Therapeutics

A biopharmaceutical company focused on developing treatments for urea cycle disorders and other rare diseases

3

Funding Rounds

$117.5m

Money raised

Siolta Therapeutics logo

Siolta Therapeutics

Siolta Therapeutics develops microbiome analyses to test microbial-based therapeutics for the treatment and prevention of inflammatory diseases. The company was founded in 2016 by Nikole Kimes PhD.

2

Funding Rounds

$30.0m

Money raised

Translate Bio logo

Translate Bio

Translate Bio is a clinical-stage mRNA therapeutics company developing medicines to treat diseases caused by protein or gene dysfunction and vaccines against infectious disease pathogens.

6

Funding Rounds

$227.7m

Money raised

OncoSenX logo

OncoSenX

OncoSenX is a spinout company of Oisin Biotechnologies, formed to develop programmable suicide gene therapy to kill cancerous cells.

5

Funding Rounds

$19.7m

Money raised

Synthorx logo

Synthorx

Synthetic biology company that created novel DNA base pairs and uses them to incorporate novel amino acids into proteins for potential therapeutics in areas of cancer and autoimmune disorders.

5

Funding Rounds

$152.0m

Money raised

Buoy Health logo

Buoy Health

Buoy is an AI-driven digital assistant that helps patients self-diagnose and triage to the appropriate care.

3

Funding Rounds

$59.2m

Money raised

ITM Isotopen Technologien Munchen logo

ITM Isotopen Technologien Munchen

ITM Isotopen Technologien Munchen is a Munich-based developer of personalized cancer diagnostic solutions.

2

Funding Rounds

$58.4m

Money raised

Odyssey Therapeutics logo

Odyssey Therapeutics

Focused on transforming lives of patients with immune dysfunctions and cancer

2

Funding Rounds

$386.0m

Money raised

Rheostat Therapeutics logo

Rheostat Therapeutics

Rheostat, located at 300 Technology Square, in Cambridge, Massachusetts is a biotech company developing treatments for neurodegenerative diseases by targeting mitophagy and autophagy pathways.

2

Funding Rounds

$46.0m

Money raised

Oraya Therapeutics logo

Oraya Therapeutics

Oraya Therapeutics is a biotechnology company developing non-invasive therapies for eye diseases that is headquartered in San Francisco, California and was founded in 2007 by Michael Gertner.

3

Funding Rounds

$64.0m

Money raised

Genecentric Diagnostics, Inc. logo

Genecentric Diagnostics, Inc.

Genecentric Diagnostics, Inc. is an oncology diagnostic and treatment center.

4

Funding Rounds

$13.9m

Money raised

Cerecin logo

Cerecin

Cerecin, formerly Accera, is a company that looks to develop therapeutic drugs for neurodegenerative diseases.

7

Funding Rounds

$189.5m

Money raised

Swiftscale Biologics logo

Swiftscale Biologics

Synthetic biology company developing vaccines and therapeutics using cell-free biology technology

2

Funding Rounds

$10.5m

Money raised

Stelvio Therapeutics logo

Stelvio Therapeutics

Stelvio Therapeutics is a biotechnology company developing therapeutics for cancer.

1

Funding Rounds

Stem Cell Theranostics logo

Stem Cell Theranostics

A biotechnology company founded in 2013 that develops technology to treat heart disease using pluripotent stem cells. Disease in a dish and clinical trial in a dish platforms are used to develop cardiovascular drugs and perform cardio-toxicity safety testing for non-cardiovascular drugs.

1

Funding Rounds

$5.5m

Money raised

Leucadia Therapeutics logo

Leucadia Therapeutics

Leucadia Therapeutics is a company working on Alzheimer's Disease.

1

Funding Rounds

Gatehouse Bio logo

Gatehouse Bio

A bio-data company that uses AI to analyze RNA sequencing data

2

Funding Rounds

$5.4m

Money raised