69 Best Therapeutics Startups to Watch in 2025

The Definitive Seedtable Ranking of Therapeutics Startups

We track 71,000+ companies and rank them dynamically using our Seedtable Score – a score that uses quantitative and qualitative data points to signal the momentum behind a company. We then monitor the list manually leveraging our expertise as founders and investors.

There are 394 start-ups with an aggregate funding of $9.4b. The average funding per company in this subset is $136.8m.

Last update to the database: Feb 18, 2025. See changelog.

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8

Funding Rounds

$406.4m

Money raised

Bolt Threads is a biotechnology company that makes high performance fabrics and materials using biology.

5

Funding Rounds

$5.1m

Money raised

Indee Labs focuses on the development of microfluidic vortex shedding for rapidly and efficiently transfecting human primary immune cells with negligible perturbation. The team is focused on developing its core technology for short turnaround chimeric antigen receptor T cell (CAR-T) development and manufacturing.

Location:

Key people:

6

Funding Rounds

$356.3m

Money raised

Insilico Medicine is a drug discovery, artificial intelligence company that looks to treat cancer and age related diseases

Location:

Key people:

8

Funding Rounds

$71.3m

Money raised

Notable Labs is a company providing personalized drug combination testing service for cancer patients.

2

Funding Rounds

$158.0m

Money raised

Senti Biosciences is a synthetic biology company.

6

Funding Rounds

$399.8m

Money raised

Human Longevity is a genomic-based, health intelligence company empowering proactive healthcare and enabling a life better lived.

Key people:

10

Funding Rounds

$635.4m

Money raised

Genomatica is a San Diego-based company founded in 2000 by Christophe Schilling.

Location:

Key people:

2

Funding Rounds

$16.8m

Money raised

Orbit Discovery offers a DNA-encoded peptide display technology to identify potential peptide drugs for a range of chronic diseases.

Industries:

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13

Funding Rounds

$386.6m

Money raised

A biotechnology company that develops medicines based on live bacterial consortia that can colonize the human intestine.

11

Funding Rounds

$50.0m

Money raised

An industrial biotech company developing a commercial bioprocess for manufacturing bio-based malonic acid.

2

Funding Rounds

$120.0m

Money raised

Scribe Therapeutics develops molecular engineering solutions for CRISPR-based genetic medicine.

1

Funding Rounds

$24.1m

Money raised

Neos Therapeutics is a pharmaceutical company developing ADHD medications founded in 2008.

5

Funding Rounds

$68.7m

Money raised

AOBiome Therapeutics is a therapeutics company, based in Newton, Massachusetts and founded in 2013, that developed strains of Ammonia Oxidizing Bacteria (AOB) to administer live in treatments that address inflammatory conditions.

Key people:

8

Funding Rounds

$117.5m

Money raised

Locus Biosciences is a biotechnology company developing CRISPR-Cas3-engineered precision antibacterial products.

Key people:

9

Funding Rounds

$82.6m

Money raised

Biotherapeautics company founded in 2014 and based in Paris that uses proprietary methods in synthetic biology, protein and genome engineering to produce Eligobiotics, products which intervene with the microbiome as diagnostics, antimicrobials and modulators of host-microbiome interactions.

Location:

Key people:

2

Funding Rounds

$13.8m

Money raised

A biopharmaceutical company developing therapeutics to attack cancer stem cells.

3

Funding Rounds

$32.0m

Money raised

miRagen is a clinical stage biopharmaceutical company developing innovative microRNA-targeting therapies to improve human health.

Key people:

1

Funding Rounds

EpiBone is a biotechnology startup company developing bone reconstruction solutions using stem cells. Nina Tandon, Sarindr Bhumiratana, Gordana Vunjak-Novakovic, and Sidney Eisig founded EpiBone in 2013 and the company is headquartered in New York City, New York.

3

Funding Rounds

$54.1k

Money raised

ApexQubit is a biotechnology company that is harnessing a proprietary technology for discovery of new medicines to treat patients with undruggable diseases.

3

Funding Rounds

$143.4m

Money raised

An exosome therapeutics company founded in 2016 and based in Oxford, UK, that uses exosomes to deliver small and large molecule therapeutics. The company has a proprietary technology to modify exosomes to target specific organs such as the brain and central nervous system.

Key people:

2

Funding Rounds

$22.8m

Money raised

Emerald Therapeutics is a biotechnology company located in San Fransisco, California, founded by Brian Frezza and DJ Klienbaum in 2010. Emerald Therapeutics offers cloud a based software and hardware platform that allows researchers to remotely perform automated scientific laboratory experiments.

6

Funding Rounds

$265.4m

Money raised

A New Zealand industrial biotechnology company developing a gas fermentation platform for converting concentrated industrial emissions into valuable chemicals.

9

Funding Rounds

$26.8m

Money raised

Envisagenics is a biotechnology company founded by Maria Luisa Pineda and Martin Akerman in 2014 and headquartered in New York City, New York using artificial intelligence and RNA sequencing to develop therapeutics to treat genetic diseases.

Key people:

8

Funding Rounds

$92.7m

Money raised

Develops medicines for patients suffering from Alzheimer's disease and other neurological disorders.

2

Funding Rounds

$164.5m

Money raised

Develops novel cell and gene therapies with pharmacologic operating systems.

2

Funding Rounds

$67.5m

Money raised

A company developing immunotherapy treatments for cancers, infectious and autoimmune diseases

3

Funding Rounds

$280.0m

Money raised

A therapeutics company founded in 2016 working in drug discovery and development using fungi. LifeMine uses genomics approaches to search for biosynthetic genes in eukaryotic microbes for the discovery of naturally inspired drugs to treat previously untreatable and significant chronic diseases.

Key people:

2

Funding Rounds

$50.3m

Money raised

Lung Therapeutics is a therapeutics for lung injury and disease company founded in 2013 by Andrew Mazar, Steven Idell and Sreerama Shetty.

2

Funding Rounds

$18.1m

Money raised

A biotechnology company that develops treatments for cancer and hematologic conditions

4

Funding Rounds

$743.2m

Money raised

A bioinformatics company in San Francisco building data collection methods and databases that will enable machine learning algorithms in healthcare. It was founded in 2018.

5

Funding Rounds

$2.5m

Money raised

Ichor Therapeutics is a pre-clinical contract research on aging mechanisms company founded in 2013 by Kelsey Moody.

Key people:

1

Funding Rounds

$750.0k

Money raised

Nextbiotics is a biotechnology and synthetic biology company that leverages synthetic biology tools and bacteriophage technology to provide solutions to the antibiotic resistance crisis.

6

Funding Rounds

$230.6m

Money raised

Leader in delivering real-world evidence (RWE) and outcomes-based analytics solutions to life science companies and payers.

Key people:

3

Funding Rounds

$39.9m

Money raised

Rodin Therapeutics was a biotechnology company that developed treatments for Alzheimer's disease. Founded in 2013, it was acquired in 2019 by Alkermes.

Key people:

4

Funding Rounds

$5.1m

Money raised

Biological micro-pancreas for insulin-dependent diabetics company

4

Funding Rounds

$7.1m

Money raised

Oisin develops anti-aging treatments that target and remove senescent cells, a type of damaged cell that is unable to divide, accumulates during aging and contribute to age-related diseases.

Location:

Key people:

3

Funding Rounds

$109.0m

Money raised

Dyno Therapeutics is a company based in Cambridge, Massachusetts applying artificial intelligence to gene therapy, focused on adeno-associated virus capsid engineering.

Key people:

2

Funding Rounds

$2.0m

Money raised

Antera Therapeutics is an allergy prevention development company.

Key people:

12

Funding Rounds

$576.4m

Money raised

SWORD Health is a digital therapy provider for pain.

Key people:

1

Funding Rounds

$1.8m

Money raised

ImStar Therapeutics is company developing treatments for ALS, dementia, and other neurodegenerative diseases.

5

Funding Rounds

$82.8m

Money raised

Peptome is a London-based protein physics intelligence company founded in 2016 by Kamil Tamiola and Matt Heberling. It utilizes artificial intelligence for computers to process all information about protein data in the same efficient way that scientists do.

Location:

Key people:

3

Funding Rounds

$67.0m

Money raised

Faeth Therapeutics is a start-up that focuses on using nutrition and metabolism to fight cancer.

Location:

Key people:

2

Funding Rounds

$55.0m

Money raised

Palvella Therapeutics is committed to developing safe and effective therapies that specifically target the root cause of genetic skin diseases.

Key people:

5

Funding Rounds

$14.5m

Money raised

Aegle Therapeutics Corporation, a regenerative medicine company isolating extracellular vesicles ("EVs") from allogeneic bone marrow derived mesenchymal stem cells (MSCs) to treat severe dermatological conditions, including burns and epidermolysis bullosa (“EB”).

Key people:

1

Funding Rounds

$100.0m

Money raised

A biotechnology company using mass spectrometry platforms for drug discovery and the development of therapeutics.

Key people:

4

Funding Rounds

$46.7m

Money raised

Juventas Therapeutics is a biotechnology company founded in 2007 that is headquartered in Cleveland, Ohio developing a pipeline of regenerative therapies to treat life-threatening diseases.

Location:

Key people:

2

Funding Rounds

$645.0k

Money raised

CHAIN Biotechnology is a live biotherapeutics company founded in 2014 and based in Nottingham and Marlow, UK. CHAIN works with the Synthetic Biology Research Centre in Nottingham and has built a live biotherapeutic platform based on Clostridia to deliver bioactive molecules to treat diseases associated with the human gut microbiome.

4

Funding Rounds

$16.8m

Money raised

YourChoice Therapeutics is a biotechnology company founded in 2018 is developing contraceptives for men and women. The technology for their non-hormonal contraceptive products arose from research at the University of California, Berkeley.

7

Funding Rounds

$443.5m

Money raised

Biofourmis is a global health IT start-up in Massachusetts that focuses on personalized care and therapies using digital therapeutics.

Key people:

3

Funding Rounds

$117.5m

Money raised

A biopharmaceutical company focused on developing treatments for urea cycle disorders and other rare diseases

Key people:

2

Funding Rounds

$30.0m

Money raised

Siolta Therapeutics develops microbiome analyses to test microbial-based therapeutics for the treatment and prevention of inflammatory diseases. The company was founded in 2016 by Nikole Kimes PhD.

6

Funding Rounds

$227.7m

Money raised

Translate Bio is a clinical-stage mRNA therapeutics company developing medicines to treat diseases caused by protein or gene dysfunction and vaccines against infectious disease pathogens.

5

Funding Rounds

$19.7m

Money raised

OncoSenX is a spinout company of Oisin Biotechnologies, formed to develop programmable suicide gene therapy to kill cancerous cells.

Location:

Key people:

5

Funding Rounds

$152.0m

Money raised

Synthetic biology company that created novel DNA base pairs and uses them to incorporate novel amino acids into proteins for potential therapeutics in areas of cancer and autoimmune disorders.

3

Funding Rounds

$59.2m

Money raised

Buoy is an AI-driven digital assistant that helps patients self-diagnose and triage to the appropriate care.

Location:

Key people:

2

Funding Rounds

$58.4m

Money raised

ITM Isotopen Technologien Munchen is a Munich-based developer of personalized cancer diagnostic solutions.

2

Funding Rounds

$386.0m

Money raised

Focused on transforming lives of patients with immune dysfunctions and cancer

2

Funding Rounds

$46.0m

Money raised

Rheostat, located at 300 Technology Square, in Cambridge, Massachusetts is a biotech company developing treatments for neurodegenerative diseases by targeting mitophagy and autophagy pathways.

3

Funding Rounds

$64.0m

Money raised

Oraya Therapeutics is a biotechnology company developing non-invasive therapies for eye diseases that is headquartered in San Francisco, California and was founded in 2007 by Michael Gertner.

4

Funding Rounds

$13.9m

Money raised

Genecentric Diagnostics, Inc. is an oncology diagnostic and treatment center.

7

Funding Rounds

$189.5m

Money raised

Cerecin, formerly Accera, is a company that looks to develop therapeutic drugs for neurodegenerative diseases.

2

Funding Rounds

$10.5m

Money raised

Synthetic biology company developing vaccines and therapeutics using cell-free biology technology

1

Funding Rounds

Stelvio Therapeutics is a biotechnology company developing therapeutics for cancer.

1

Funding Rounds

$5.5m

Money raised

A biotechnology company founded in 2013 that develops technology to treat heart disease using pluripotent stem cells. Disease in a dish and clinical trial in a dish platforms are used to develop cardiovascular drugs and perform cardio-toxicity safety testing for non-cardiovascular drugs.

1

Funding Rounds

Leucadia Therapeutics is a company working on Alzheimer's Disease.

2

Funding Rounds

$5.4m

Money raised

A bio-data company that uses AI to analyze RNA sequencing data

Key people:

14

Funding Rounds

$1.2b

Money raised

Insightec is a Tirat Carmel-based company developing and manufacturing MR-guided focused ultrasound devices for image-guided acoustic surgery.

1

Funding Rounds

$3.9m

Money raised

Tempo Therapeutics is an interventional biomaterials for regenerative medicine company founded by Westbrook Weaver.

Key people:

2

Funding Rounds

$195.5m

Money raised

JW (Cayman) Therapeutics Co. Ltd is a Shanghai-based developer of cell-based therapy technologies for cancer treatment.

Location:

Key people:

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