69 Best Startups in North Carolina to Watch in 2025

The Definitive Seedtable Ranking of Startups in North Carolina

We track 71,000+ companies and rank them dynamically using our Seedtable Score – a score that uses quantitative and qualitative data points to signal the momentum behind a company. We then monitor the list manually leveraging our expertise as founders and investors.

There are 699 start-ups with an aggregate funding of $8.7b. The average funding per company in this subset is $125.9m.

Last update to the database: Feb 18, 2025. See changelog.

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2

Funding Rounds

$7.9m

Money raised

t3rn is a hosting platform for smart contracts, that enables trustless, interoperable, multi-chain execution and composable collaboration.

6

Funding Rounds

$214.0m

Money raised

ScienceLogic is an IT Operations Management company providing IT infrastructure monitoring and AIOps solutions for hybrid cloud management.

6

Funding Rounds

$136.5m

Money raised

Egnyte delivers secure content collaboration, compliant data protection, and simple infrastructure modernization, all through a single SaaS solution.

Key people:

10

Funding Rounds

$930.0m

Money raised

Tempus, a technology company advancing precision medicine through the practical application of artificial intelligence in healthcare.

4

Funding Rounds

$55.1m

Money raised

Pryon is a company providing an artificial intelligence platform that reads, organizes, and retrieves data.

3

Funding Rounds

$22.8m

Money raised

Distil Networks was an American cybersecurity company founded in 2011 and headquartered in San Francisco, California.

6

Funding Rounds

$303.0m

Money raised

VAST Data is a developer of a data storage platform designed to manage storage software unlocking the value of data and modernizing data centers in preparation for the era of AI computing.

3

Funding Rounds

$14.0m

Money raised

EthSign is a decentralized, versioned, and consensus-based electronic agreements signing application built on Ethereum, IPFS, and Filecoin.

9

Funding Rounds

$434.1m

Money raised

SingleStore is a San Francisco-based database software and analytics company offering a platform to help companies operationalize their data.

8

Funding Rounds

$117.5m

Money raised

Locus Biosciences is a biotechnology company developing CRISPR-Cas3-engineered precision antibacterial products.

5

Funding Rounds

$103.1m

Money raised

Promethera Biosciences is a biotechnology company developing regenerative medicine treatments for liver diseases.

9

Funding Rounds

$616.0m

Money raised

A company offering a cloud platform for digital product creators and product development teams.

4

Funding Rounds

$19.4m

Money raised

Allstacks is a value stream intelligence platform giving software organizations visibility and insights into how well they build software and shape their outcomes.

5

Funding Rounds

$57.1m

Money raised

Metabolon is a company developing metabolomics analytical methods and software for biomarker discovery

4

Funding Rounds

$150.0m

Money raised

Net Power is a Durham, North Carolina-based natural gas electricity producer using carbon capture and storage to maintain zero emissions production.

2

Funding Rounds

$67.5m

Money raised

A company developing immunotherapy treatments for cancers, infectious and autoimmune diseases

1

Funding Rounds

$250.0k

Money raised

Galaxy Digital is an Asheville, North Carolina-based company founded in 2009 by Doss Church.

4

Funding Rounds

$479.5m

Money raised

Formerly BioMedicines, Intarcia Therapeutics is an American biopharmaceutical company developing therapies for diseases with long-term treatment requirements.

2

Funding Rounds

$12.8m

Money raised

Developer of a healthcare platform designed to simplify personal health data. The company's platform captures data from clinical and remote-monitoring devices, sensors, fitness equipment, and patient-wellness applications, enabling users to access, manage and utilize device-generated data.

1

Funding Rounds

$400.0m

Money raised

Dole Food Company is an american agricultural multinational corporation founded in 1851 by Samuel Northrup Castle.

3

Funding Rounds

$8.0m

Money raised

Improved Nature is a plant-based food technology company operating out of Garner, North Carolina that was founded in 2015 by Richard Hawkins, Steve Klawiter, Larry Chandler, Moshe Meidan and Sarid Shefet.

9

Funding Rounds

$2.5m

Money raised

Corvid Technologies is a Mooresville, North Carolina-based supercomputer company founded in 2004.

4

Funding Rounds

$13.9m

Money raised

Genecentric Diagnostics, Inc. is an oncology diagnostic and treatment center.

1

Funding Rounds

$21.0m

Money raised

A company that cultures human mammary cells and produces custom and commercial lab-grown breastmilk. It was founded in 2020 and is located in Durham, North Carolina.

2

Funding Rounds

$6.2m

Money raised

A biotechnology company with a focus on developing medical solutions with biomaterial. It was founded in 2015 and is located in Durham, North Carolina.

2

Funding Rounds

$83.0m

Money raised

bioMASON's is a company that uses organisms to grow biocementTM based construction materials.

1

Funding Rounds

$16.0m

Money raised

A pharmaceutical company that develops topical products to treat rare diseases

2

Funding Rounds

$10.2m

Money raised

Resilient Biotics is utilizing advanced microbiome genomics and data science for prevention and precision treatment of deadly infectious diseases.

3

Funding Rounds

$36.5m

Money raised

Covenant Surgical Partners is a company that operates ambulatory surgery centers founded in 2008.

1

Funding Rounds

$2.9m

Money raised

Distelli is a privately held infrastructure automation company based in Seattle, Washington.

12

Funding Rounds

$273.6m

Money raised

Vestaron is a Kalamazoo, Michigan-based agricultural technology company manufacturing bioinsecticides from naturally occurring peptides

1

Funding Rounds

$6.5m

Money raised

Fluree is a Winston Salem, NC-based company developing a web3 data platform.

3

Funding Rounds

$10.7m

Money raised

Suite of APIs that help brands build custom ad platforms.

10

Funding Rounds

$255.8m

Money raised

PrecisionHawk is a Raleigh, North Carolina-based drone company developing drone and data products for the energy, agriculture, and telecommunications industries.

4

Funding Rounds

$9.5m

Money raised

UserVoice is a company founded in 2008 by Richard White, Scott Rutherford and Lance Ivy.

1

Funding Rounds

$1.0m

Money raised

Pendo Systems is a financial tech company that provides tools and technology such as artificial intelligence and machine learning to financial institutions.

5

Funding Rounds

$78.0m

Money raised

CloudFactory is an outsourcing company offering human-powered data processing services for artificial intelligence and automation companies.

7

Funding Rounds

$252.5m

Money raised

AgBiome is focused on the discovery and development of biological and trait products for crop production.

4

Funding Rounds

$38.0m

Money raised

Payzer is a Charlotte, North Carolina-based software development company and payments platform.

6

Funding Rounds

$80.4m

Money raised

Spreedly is the last payments API you'll ever need: - Cut PCI risk and boost flexibility with secure card capture and storage - Connect once, integrate with 220+ payment services - Drive more business, in more markets, with more partners See how you can start today: https://www.spreedly.com Spreedly provides cloud-based PCI Level-1 infrastructure for payments software. Businesses use Spreedly to connect to multiple payment gateways, payment receivers, and a secure credit card vault - all through a single API. That enables our customers to do more business, in more markets, with more partners - all while minimizing PCI compliance scope.

1

Funding Rounds

$7.3m

Money raised

An insurance technology company offering artificially intelligent drone software managements systems for insurance companies.

3

Funding Rounds

$1.6m

Money raised

Shiloh's Five Loaves, Inc. is a Burlington, North Carolina-based company.

4

Funding Rounds

$41.7m

Money raised

Baebies, Inc. is a Durham, North Carolina-based medical diagnostics company delivering products and services for newborn screening and pediatric testing founded in 2013.

5

Funding Rounds

$21.0m

Money raised

Kevel offers the infrastructure APIs needed to build custom ad platforms for sponsored listings, internal promotions, native ads, and more.

4

Funding Rounds

$343.1m

Money raised

Encoded Therapeutics is a developer of genomics-driven precision medicine targeting and treating genetic diseases and disorders.

6

Funding Rounds

$25.3m

Money raised

Credible is a student loan marketplace founded in 2012 by Stephen Dash.

4

Funding Rounds

$10.8m

Money raised

Automated Insights is a Durham, North Carolina-based company offering content automation services and founded in 2007 by Robbie Allen.

4

Funding Rounds

$241.9m

Money raised

Asklepios Biopharmaceutical is a company in North Carolina.

4

Funding Rounds

$25.7m

Money raised

Choose Energy is a Texas-based marketplace company offering clean technology and service to help consumers shopping for electricity and natural gas rates.

3

Funding Rounds

$8.0m

Money raised

ReverbNation is a website that is meant to connect artists to the music industry

3

Funding Rounds

$1.4b

Money raised

Resilience Technology Corporation is an Hanover, Maryland-based cybersecurity company developing and manufacturing cyber security tools and founded in 1995.

3

Funding Rounds

$920.0k

Money raised

MuukTest is a software testing platform powered by AI that increases Software Devs testing productivity up to 26X

1

Funding Rounds

$1.0m

Money raised

Cloosiv provides a mobile ordering platform for local coffee shops. The company was founded in 2017 and is located in Charlotte, North Carolina.

8

Funding Rounds

$278.2m

Money raised

Company

4

Funding Rounds

$37.9m

Money raised

Phreesia is a healthcare software company offering services including appointment scheduling, clinical support, patient activation and surveys, analytics and reports, and patient registration.

3

Funding Rounds

$198.0m

Money raised

Passport is a company founded in 2010.

1

Funding Rounds

$1.2m

Money raised

Brainvectis is a biotechnology company developing treatments for neurodegenerative diseases through restoring cholesterol metabolism in the brain.

3

Funding Rounds

$156.0m

Money raised

Forty Seven is a Foster City, California-based company founded in 1987.

2

Funding Rounds

$3.5m

Money raised

Diveplane is a Raleigh, North Carolina-based company founded in 2018.

5

Funding Rounds

$48.3m

Money raised

Sense Photonics is a company building LiDAR and 3D sensor solutions for autonomous vehicles, industrial robotics, material handling, activity monitoring, and other applications.

1

Funding Rounds

$23.1m

Money raised

NeuroTronik is a company that develops neurostimulation therapeutic devices which are designed to treat acute heart failure syndrome.

5

Funding Rounds

$35.0m

Money raised

Valencell is a Raleigh, North Carolina-based company developing biometric sensor technology for wearable and hearable OEM's.

12

Funding Rounds

$163.4m

Money raised

Titan Medical (TSE: TMD) isa company in North Carolina.

1

Funding Rounds

$3.0m

Money raised

LoanWell is a End-to-End platform for Lenders with Intake, Origination, Underwriting, Closing, Servicing, & Reporting all in one platform. Our system can be completely branded and customized (like Squarespace) and is specifically designed with flexibility in mind for the multi-faceted origination and servicing needs of Lenders.

2

Funding Rounds

$115.0m

Money raised

Pairwise uses CRISPR, gene editing and natural diversity in agricultural crops to address global food challenges. The company is working to develop new varieties of crops.

1

Funding Rounds

$1.6m

Money raised

We use land-first models to provide mass appraisal modeling and property valuations with unparalleled accuracy.

14

Funding Rounds

$73.9m

Money raised

Aruna Biomedical, Inc. is a stem Cell Research Products founded in 2003 by Tracey Worthington-Stice.

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