68 Best Startups in North Carolina to Watch in 2025

The Definitive Seedtable Ranking of Startups in North Carolina

We track 71,000+ companies and rank them dynamically using our Seedtable Score – a score that uses quantitative and qualitative data points to signal the momentum behind a company. We then monitor the list manually leveraging our expertise as founders and investors.

There are 93 start-ups with an aggregate funding of $4.8b. The average funding per company in this subset is $70.0m.

Last update to the database: Feb 18, 2025. See changelog.

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8

Funding Rounds

$117.5m

Money raised

Locus Biosciences is a biotechnology company developing CRISPR-Cas3-engineered precision antibacterial products.

Key people:

2

Funding Rounds

$10.2m

Money raised

Resilient Biotics is utilizing advanced microbiome genomics and data science for prevention and precision treatment of deadly infectious diseases.

1

Funding Rounds

$6.5m

Money raised

Fluree is a Winston Salem, NC-based company developing a web3 data platform.

4

Funding Rounds

$9.5m

Money raised

UserVoice is a company founded in 2008 by Richard White, Scott Rutherford and Lance Ivy.

Key people:

7

Funding Rounds

$252.5m

Money raised

AgBiome is focused on the discovery and development of biological and trait products for crop production.

4

Funding Rounds

$41.7m

Money raised

Baebies, Inc. is a Durham, North Carolina-based medical diagnostics company delivering products and services for newborn screening and pediatric testing founded in 2013.

4

Funding Rounds

$343.1m

Money raised

Encoded Therapeutics is a developer of genomics-driven precision medicine targeting and treating genetic diseases and disorders.

6

Funding Rounds

$25.3m

Money raised

Credible is a student loan marketplace founded in 2012 by Stephen Dash.

4

Funding Rounds

$241.9m

Money raised

Asklepios Biopharmaceutical is a company in North Carolina.

Key people:

3

Funding Rounds

$1.4b

Money raised

Resilience Technology Corporation is an Hanover, Maryland-based cybersecurity company developing and manufacturing cyber security tools and founded in 1995.

Key people:

12

Funding Rounds

$163.4m

Money raised

Titan Medical (TSE: TMD) isa company in North Carolina.

14

Funding Rounds

$73.9m

Money raised

Aruna Biomedical, Inc. is a stem Cell Research Products founded in 2003 by Tracey Worthington-Stice.

2

Funding Rounds

$213.9m

Money raised

AAVANTIBio is a biotechnology company developing gene therapies.

3

Funding Rounds

$90.4m

Money raised

PlantResponse is a biotechnology company developing soil health solutions and products for crop nutrition.

3

Funding Rounds

$97.2m

Money raised

StrideBio is a Durham, North Carolina-based company.

3

Funding Rounds

$455.6m

Money raised

Kriya Therapeutics is a gene Therapy founded in 2019 by Shankar Ramaswamy, J. Fraser Wright and Roger Jeffs.

1

Funding Rounds

$3.0m

Money raised

A company developing application-specific coatings and medical devices for the orthopedic and cardiovascular fields

3

Funding Rounds

$92.0m

Money raised

Micro-organosphere technologies to guide precision therapy for cancer patients

1

Funding Rounds

$168.0k

Money raised

medlio is a company founded in 2013 by Lori Mehen, David S. Brooks and Ravi Ada.

3

Funding Rounds

$17.6m

Money raised

A biotechnology company developing intracellular genetic protein therapy to treat chronic heart failure

Key people:

2

Funding Rounds

$63.1m

Money raised

Atsena Therapeutics, Inc. is a gene Therapy founded in 2019.

1

Funding Rounds

Reach Analytics is a company that provides cloud-based predictive marketing for businesses.

1

Funding Rounds

$3.2m

Money raised

LearnPlatform is a company founded in 2019 by Karl Rectanus.

1

Funding Rounds

$70.0m

Money raised

Well is a healthcare app founded in 2019 by Gary Loveman.

Location:

Key people:

5

Funding Rounds

$39.8m

Money raised

Ceterus is a company founded by Levi Morehouse.

7

Funding Rounds

$70.0m

Money raised

Get Spiffy, Inc is a cleaning company founded in 2014 by Karl Murphy.

Industries:

Key people:

2

Funding Rounds

$11.3m

Money raised

Netsertive is a company founded in 2009.

2

Funding Rounds

$20.0m

Money raised

StrongKey (formerly StrongAuth) is a leader in Enterprise Key Management Infrastructure, bringing new levels of capability and data security at a price point significantly lower than other solutions.

1

Funding Rounds

$550.8k

Money raised

An infectious disease diagnostics company developing Bartonella and pathogen testing services

4

Funding Rounds

$2.6m

Money raised

Tanjo.AI is a company founded by David Smith, AJ Peralta, Eric Smith and Richard Boyd.

Key people:

1

Funding Rounds

$40.0m

Money raised

Gaia Herbs grows and produces certified organic herbal products, including liquid extracts, functional powders and herbal teas. All growing, manufacturing, processing, researching, packaging and distribution takes place in its North Carolina facilities.

4

Funding Rounds

$26.6m

Money raised

Centice is a company that develops pharmaceutical authentication sensor system founded in 2003 by David Brady.

1

Funding Rounds

$12.7m

Money raised

Cell Microsystems is a North Carolina-based company developing, manufacturing, and marketing products for single-cell biology.

2

Funding Rounds

$18.2m

Money raised

BioFluidica is a San Diego-based company developing liquid biopsy technology founded by Steven A. Soper.

1

Funding Rounds

$25.0m

Money raised

Envisia Therapeutics is a biotechnology company developing ocular therapies founded in 2013.

1

Funding Rounds

AgEye is an AI-powered platform for indoor farming that monitors every moment, of every plant, to increase yields and reduce operational costs.

2

Funding Rounds

$9.0m

Money raised

TheraVida is a company developing therapies for hyperhidrosis.

1

Funding Rounds

$2.2m

Money raised

Rownd is a company founded in 2020 by Rachel Radulovich.

Industries:

Key people:

3

Funding Rounds

$6.9m

Money raised

Carpe is a company founded in 2014.

1

Funding Rounds

$8.4m

Money raised

Seeing Medicines is developing regenerative medicine treatments to restore and maintain vision in people with macular degenerative diseases such as Age-related Macular Degeneration (AMD), Best Disease and Stargardt's Disease..

1

Funding Rounds

$9.8m

Money raised

Skylight is a company founded in 2016.

1

Funding Rounds

$2.0m

Money raised

GeneVentiv Therapeutics is a gene therapy company developing treatments for blood diseases and disorders, including treatments for Hemophilia A and B with or without inhibitors and for Hemophilia Arthropathy, a degenerative joint disease.

1

Funding Rounds

$500.0k

Money raised

RainBio is developing AAV (adeno-associated virus) gene therapy corneal treatments to address the unmet need of treatment of rare corneal blinding diseases.

Key people:

1

Funding Rounds

$8.0m

Money raised

Geomagic is a North Carolina-based company founded in 1994.

5

Funding Rounds

$7.8m

Money raised

5

Funding Rounds

$13.7m

Money raised

Deep Blue Medical Advances is a hernial Mesh.

2

Funding Rounds

$12.3m

Money raised

Basking Biosciences, Inc. is a company founded in 2019 by Shahid Nimjee.

Key people:

2

Funding Rounds

$7.2m

Money raised

Altis Biosystems, Inc. is a biotechnology company founded in 2018.

1

Funding Rounds

$751.0k

Money raised

inMotionNow.com is a company founded in 2017.

1

Funding Rounds

$140.0m

Money raised

CData Software is a leading provider of data access and connectivity solutions.

1

Funding Rounds

$30.0m

Money raised

Incyclix Bio is a biotechnology research company.

3

Funding Rounds

$2.4m

Money raised

Arrevus, Inc. is a company founded in 2015.

1

Funding Rounds

$105.0m

Money raised

Pathalys Pharma is a biopharmaceutical company developing treatments for chronic kidney disease, with a focus on managing hyperphosphatemia in patients.

Industries:

Location:

1

Funding Rounds

$1.8m

Money raised

FastBack Bio is developing CAR-T therapy for treatment of solid tumors.

1

Funding Rounds

A company offering a knowledge management and technical article platform focused on helping developers.

4

Funding Rounds

$5.7m

Money raised

Wellnecity Group, Inc. is a North Carolina-based analytics company founded in 2018.

Industries:

Location:

1

Funding Rounds

$17.2m

Money raised

Overture Networks is a North Carolina-based company founded in 2000.

Location:

2

Funding Rounds

$9.0m

Money raised

Live Furnish, Inc. is a company founded in 2017.

4

Funding Rounds

$11.7m

Money raised

Eton Solutions, L.P. is a North Carolina-based company.

Location:

2

Funding Rounds

$159.7m

Money raised

CDATA SOFTWARE, INC. is a North Carolina-based company founded in 2020.

Location:

1

Funding Rounds

$5.0m

Money raised

CAMRAS VISION, INC. is a North Carolina-based company.

Location:

2

Funding Rounds

$1.5m

Money raised

Eton Technologies, L.P. is a North Carolina-based company founded in 2012.

Location:

3

Funding Rounds

$41.9m

Money raised

Evecxia, Inc. is a North Carolina-based mental health company founded in 2013.

Industries:

Location:

1

Funding Rounds

$3.4m

Money raised

3

Funding Rounds

$31.0m

Money raised

UWHARRIE CAPITAL CORP is a North Carolina-based banking company.

Industries:

Location:

1

Funding Rounds

$1.0

Money raised

Fairfax Hotel Investors LLC is a North Carolina-based company in the hospitality industry founded in 2019.

Industries:

Location:

1

Funding Rounds

$1.0

Money raised

Fairfax Hotel Property Owners LLC is a North Carolina-based company in the hospitality industry founded in 2019.

Industries:

Location:

2

Funding Rounds

$12.2m

Money raised

PatientPay is a North Carolina-based company.

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