69 Best Startups in San Diego to Watch in 2025

The Definitive Seedtable Ranking of Startups in San Diego

We track 71,000+ companies and rank them dynamically using our Seedtable Score – a score that uses quantitative and qualitative data points to signal the momentum behind a company. We then monitor the list manually leveraging our expertise as founders and investors.

There are 4,855 start-ups with an aggregate funding of $51.4b. The average funding per company in this subset is $745.3m.

Last update to the database: Feb 18, 2025. See changelog.

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7

Funding Rounds

$18.2b

Money raised

OpenAI is an AI research and deployment platform.

3

Funding Rounds

$364.2m

Money raised

Neuralink is a company that develops brain-computer interface (BCI) devices to assist people with paralysis and blindness and technologies that may expand the abilities of humans.

7

Funding Rounds

$10.1m

Money raised

Cere Network is a decentralized data cloud platform built on Polkadot.

9

Funding Rounds

$570.0m

Money raised

Dialpad is a San Francisco-headquartered business communications platform company.

4

Funding Rounds

$910.0m

Money raised

An end-to-end blockchain and NFT solution for video games.

5

Funding Rounds

$5.0b

Money raised

AI safety and research platform.

Key people:

1

Funding Rounds

$9.0m

Money raised

Tendermint is now Ignite. Tendermint was the core contributor to the Cosmos blockchain network.

6

Funding Rounds

$799.8m

Money raised

A bank offering online banking services with no user no bank fees, and an option to receive direct deposit up to two days early. Chris Britt and Ryan King founded Chime in 2013, and the company is headquartered in San Francisco, California.

1

Funding Rounds

$35.0m

Money raised

Fractal is a gaming marketplace developed to facilitate non-fungible tokens (NFTs).

3

Funding Rounds

$17.5m

Money raised

Numerai is a hedge fund with stock market trades determined by crowdsourced artificial intelligence models. The best models receive rewards in the form of a cryptographic token called Numeraire (NMR) on the Ethereum blockchain.

1

Funding Rounds

$10.0m

Money raised

LangChain is an open-source framework for developing applications powered by language models.

1

Funding Rounds

$31.0m

Money raised

An online publishing platform used by amateur and professional writers. Membership fees are used to pay writers.

2

Funding Rounds

$27.0m

Money raised

CryptoKitties is a game built on the Ethereum blockchain in which users can collect and trade virtual kittens.

4

Funding Rounds

$583.6m

Money raised

TriNet Zenefits is a software as a service (SaaS) company providing a digital human resources platform for small- and medium-sized enterprises (SMEs).

5

Funding Rounds

$263.1m

Money raised

Mammoth Biosciences is an American company based in San Francisco founded on June 1, 2017. Mammoth Biosciences uses CRISPR technology to develop bio-sensing technologies for diagnostics in industries such as healthcare, agriculture, manufacturing, and forensics and genome editing therapeutics.

6

Funding Rounds

$292.4m

Money raised

Calm is a health technology start-up based in San Francisco. It was founded in 2012 by Alex Tew and Michael Acton Smith and produces a mobile application for sleep, relaxation, and meditation.

3

Funding Rounds

$119.2m

Money raised

Phantom is a cryptocurrency wallet by Solana to manage digital assets and access decentralized applications.

4

Funding Rounds

$230.0m

Money raised

Humane develops and commercializes consumer hardware, software, and services.

6

Funding Rounds

$1.7b

Money raised

Discord is an American company that offers users a free messenger with support for IP telephony and video conferencing. About 56 million people use the Discord messenger every month, and its total audience exceeds 270 million users.

1

Funding Rounds

$50.0k

Money raised

Pembient uses advances in biotechnology to fabricate horn and other wildlife products to combat the threat to endangered species.

9

Funding Rounds

$307.0m

Money raised

Forge, formerly Equidate, is a company that offers a marketplace for private stock liquidation.

5

Funding Rounds

$349.2m

Money raised

HashiCorp is a software company providing tools for developers and security professionals to provision, secure, and run infrastructure for distributed applications for organizations.

4

Funding Rounds

$74.3m

Money raised

Pachama is a company estimating carbon storage in forests and predicting future deforestation or potential for forest restoration with the use of satellite images.

8

Funding Rounds

$274.7m

Money raised

Sisense is a software company offering a platform for data analysts and data engineers to transform data into actionable business insights.

3

Funding Rounds

$34.0m

Money raised

Parallel Finance is a decentralized lending and staking protocol on Polkadot and Ethereum.

5

Funding Rounds

$5.1m

Money raised

Indee Labs focuses on the development of microfluidic vortex shedding for rapidly and efficiently transfecting human primary immune cells with negligible perturbation. The team is focused on developing its core technology for short turnaround chimeric antigen receptor T cell (CAR-T) development and manufacturing.

9

Funding Rounds

$1.5b

Money raised

Faire is a curated boutique wholesale marketplace connecting local retailers with thousands of emerging and established brands.

3

Funding Rounds

$54.2m

Money raised

Layer1 is a cryptocurrency investment and infrastructure platform.

10

Funding Rounds

$6.0b

Money raised

Flexport is a licensed freight forwarder and shipping company based in San Francisco, CA, USA. They manage global logistics for businesses.

10

Funding Rounds

$1.3b

Money raised

Brex is a credit card company that issues corporate credit cards with no security deposit.

Location:

Key people:

4

Funding Rounds

$204.7m

Money raised

Primer is a San Francisco-based company developing AI to generate written intelligence reports.

1

Funding Rounds

$150.0k

Money raised

GitStart is a "Pull Request as a Service" platform founded in 2019 by Hamza Zia.

2

Funding Rounds

$336.0m

Money raised

Mysten Labs creates foundational infrastructure to accelerate the adoption of Web3.

JSquare is a San Francisco-based company founded in 1985 by Jeff Herman.

6

Funding Rounds

$157.0m

Money raised

Data.ai, formerly known as App Annie, is a unified data and artificial intelligence (AI) company that combines consumer and market data to provide AI-powered insights into mobile app market data.

2

Funding Rounds

$110.0m

Money raised

Clubhouse is a San Francisco-based social app offering a space for casual, drop-in audio conversations with friends and other interesting people.

3

Funding Rounds

$54.4m

Money raised

Sightcall is a San Francisco-based company founded in 2008.

1

Funding Rounds

$27.5k

Money raised

Full Circle Biochar is a developer of products and technologies based on bio-charcoal for the agricultural markets.

4

Funding Rounds

$165.0m

Money raised

Elastic is a software company that creates products for searching for information on the Internet. It was founded in 2012 and is headquartered in San Francisco and Amsterdam.

7

Funding Rounds

$711.5m

Money raised

Perfect Day Foods (formerly Muufri) engineered yeast capable of producing the proteins found in cows milk. They use these proteins to make their own line of animal-free dairy products.

3

Funding Rounds

$47.0m

Money raised

Paravision is a San Francisco-based provider of facial recognition and activity monitoring software. Paravision was previously known as Ever AI.

9

Funding Rounds

$217.2m

Money raised

Density is a San Francisco-based company building a people-counting system to measure the number of people in or passing through a physical space such as a hallway, lobby, or conference hall.

5

Funding Rounds

$241.5m

Money raised

Hasura is a software and development tools company, offering tools for developers to simplify application development.

1

Funding Rounds

$1.2m

Money raised

Artificial intelligence company who uses models and IBM's Watson in the management of their AI Powered Equity Fund ETF (AIEQ) and AI Powered International Equity ETF (AIIQ)

5

Funding Rounds

$121.0m

Money raised

A company offering an email client designed to be the fastest email experience. The company was founded by Conrad Irwin, Rahul Vohra, and Vivek Sodera in 2015 and is headquartered in San Francisco, California.

6

Funding Rounds

$203.6m

Money raised

Loom is a software company that develops communication software for asynchronous presentations through sharable video recordings.

4

Funding Rounds

$107.0m

Money raised

TrustArc is a San Francisco-based developer of privacy compliance and risk management software for GDPR, CCPA, and related regulations.

4

Funding Rounds

$118.5m

Money raised

Juicero was a company founded in 2013 that produced and sold an expensive juicer called the Juicero Press, along with fresh produce packets. The company closed after it received extensive negative press regarding its simplistic machine in contrast with its high cost.

1

Funding Rounds

$13.5m

Money raised

MetaMap aims to digitize trust

5

Funding Rounds

$87.5m

Money raised

CodeSignal is developing a skills-based assessment platform for unbiased hiring within companies.

1

Funding Rounds

$1.2m

Money raised

Zapier is an American for-profit corporation and a web-based service that allows end users to integrate the web applications they use.

2

Funding Rounds

$15.6m

Money raised

Protera is a biotechnology company that works with protein engineering to address challenges in food, agriculture, the environment, and human health.

9

Funding Rounds

$20.3m

Money raised

New Wave Foods is a biotechnology company developing plant-based shellfish food products. The company is based out of San Francisco, California and was founded in 2015 by Dominique Barnes and Michelle Wolf.

4

Funding Rounds

$43.9m

Money raised

Iterative.ai is a machine learning and artificial intelligence training platform provider.

4

Funding Rounds

$108.0m

Money raised

PlanetScale is a database-as-a-service platform acting as a middleware system for MySQL.

5

Funding Rounds

$433.0m

Money raised

Postman is a San Francisco-based software company offering an API development environment.

8

Funding Rounds

$220.0m

Money raised

Just, Inc. (formerly known as Hampton Creek) is a food technology company developing and selling plant based food products around the world.

2

Funding Rounds

$13.9m

Money raised

Tacit Knowledge is a London-headquartered software and IT consulting company developing enterprise software solutions for digital commerce companies.

5

Funding Rounds

$115.9m

Money raised

Nurx is a telemedicine service company that delivers oral contraceptives and various testing kits to its customers. It was founded in 2015 and has headquarters in San Francisco, California.

6

Funding Rounds

$775.6m

Money raised

Scale AI is an artificial intelligence company making an API for validating and training data for applications.

2

Funding Rounds

$8.5m

Money raised

DeHorizon is committed to becoming the next generation of Metaverse Game Ecosystem, where players can immersively create, socialize, entertain with other peer players.

8

Funding Rounds

$180.7m

Money raised

Bugcrowd is an enterprise cloud computing and computer security crowdsourcing company that offers a platform for security testing, web, mobile, source code, and client-side applications.

8

Funding Rounds

$551.0m

Money raised

Eat Just is a San Francisco based food technology company founded in 2011. The company is known for its bean-based egg substitute called Just Egg. Eat Just also produces egg-free mayonnaise.

4

Funding Rounds

$580.8m

Money raised

Upside Foods is a San Francisco-based company making cultured meat products. The company was founded by Uma Valeti, Nicholas Genovese, and Will Clem.

4

Funding Rounds

$1.8b

Money raised

Grail is a biotechnology company headquartered in Menlo Park, California that was founded as a spinoff of Illumina Inc and initially headed by Jeffrey Huber in 2016, focused on making a medical device that can detect early stage cancer.

11

Funding Rounds

$4.1b

Money raised

The World's First Digital Clinic for Back and Joint Pain

2

Funding Rounds

$2.0m

Money raised

Plivo is a cloud-based communications platform as a service (CPaaS) company headquartered in San Francisco, California. The company allows software developers to integrate phone calls, text messages, and other communication functions into their applications using its web service APIs.

3

Funding Rounds

$22.8m

Money raised

Distil Networks was an American cybersecurity company founded in 2011 and headquartered in San Francisco, California.

4

Funding Rounds

$477.4m

Money raised

Grove Collaborative is an online, subscription-based retailer selling natural home and health products.

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