69 Best Startups in United States to Watch in 2025

The Definitive Seedtable Ranking of Startups in United States

We track 71,000+ companies and rank them dynamically using our Seedtable Score – a score that uses quantitative and qualitative data points to signal the momentum behind a company. We then monitor the list manually leveraging our expertise as founders and investors.

There are 3,531 start-ups with an aggregate funding of $21.8b. The average funding per company in this subset is $315.7m.

Last update to the database: Feb 18, 2025. See changelog.

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Neuralink logo

Neuralink

Neuralink is a company that develops brain-computer interface (BCI) devices to assist people with paralysis and blindness and technologies that may expand the abilities of humans.

3

Funding Rounds

$364.2m

Money raised

Dialpad logo

Dialpad

Dialpad is a San Francisco-headquartered business communications platform company.

9

Funding Rounds

$570.0m

Money raised

Sprint logo

Sprint

Sprint is a company founded by Cleyson L. Brown.

1

Funding Rounds

Mutable logo

Mutable

Developer of low-latency and high-throughput broadband networks for AR/VR, IoT, robotics, and other emerging technologies.

1

Funding Rounds

$1.5m

Money raised

Ignite logo

Ignite

Tendermint is now Ignite. Tendermint was the core contributor to the Cosmos blockchain network.

1

Funding Rounds

$9.0m

Money raised

Chime Bank logo

Chime Bank

A bank offering online banking services with no user no bank fees, and an option to receive direct deposit up to two days early. Chris Britt and Ryan King founded Chime in 2013, and the company is headquartered in San Francisco, California.

6

Funding Rounds

$799.8m

Money raised

Numerai logo

Numerai

Numerai is a hedge fund with stock market trades determined by crowdsourced artificial intelligence models. The best models receive rewards in the form of a cryptographic token called Numeraire (NMR) on the Ethereum blockchain.

3

Funding Rounds

$17.5m

Money raised

CryptoKitties logo

CryptoKitties

CryptoKitties is a game built on the Ethereum blockchain in which users can collect and trade virtual kittens.

2

Funding Rounds

$27.0m

Money raised

Wavel.ai logo

Wavel.ai

Wavel.ai is a voice AI solution for scaling and localizing video content.

1

Funding Rounds

$510.0k

Money raised

BrainStation logo

BrainStation

BrainStation offers full-time and part-time courses in data science, design, development, marketing, cyber security and product in New York City, Miami, London, Toronto, Vancouver, and through an Online Live platform.

1

Funding Rounds

$500.0k

Money raised

Celo logo

Celo

Celo is an open platform that offers financial tools to mobile phone users.

5

Funding Rounds

$126.5m

Money raised

TriNet Zenefits logo

TriNet Zenefits

TriNet Zenefits is a software as a service (SaaS) company providing a digital human resources platform for small- and medium-sized enterprises (SMEs).

4

Funding Rounds

$583.6m

Money raised

Arzeda logo

Arzeda

Arzeda is a biotechnology and software company designing custom microorganisms for industrial applications through computational enzyme design, protein optimization, and metabolic engineering.

5

Funding Rounds

$72.2m

Money raised

Calm logo

Calm

Calm is a health technology start-up based in San Francisco. It was founded in 2012 by Alex Tew and Michael Acton Smith and produces a mobile application for sleep, relaxation, and meditation.

6

Funding Rounds

$292.4m

Money raised

Swarm Technologies logo

Swarm Technologies

Swarm Technologies is a nanosatellite manufacturer and operator.

2

Funding Rounds

$27.7m

Money raised

Impossible Foods logo

Impossible Foods

Impossible Foods is a plant-based meat company making meat and dairy products that are made to look and feel like animal products by manufacturing heme, the oxygen binding molecule found in blood, using engineered yeast grown in bioreactors.

11

Funding Rounds

$1.9b

Money raised

Bolt Threads logo

Bolt Threads

Bolt Threads is a biotechnology company that makes high performance fabrics and materials using biology.

8

Funding Rounds

$406.4m

Money raised

Made In Space logo

Made In Space

Company developing space manufacturing technologies to support exploration, national security, and sustainable space settlement.

3

Funding Rounds

Immunefi logo

Immunefi

Immunefi is a bug bounty security services platform that focuses on bug bounty and security services for Web3 projects.

2

Funding Rounds

$29.5m

Money raised

Layer1 logo

Layer1

Layer1 is a cryptocurrency investment and infrastructure platform.

3

Funding Rounds

$54.2m

Money raised

NUVIA (company) logo

NUVIA (company)

Nuvia develops semiconductor components and high-performance processors designed for compute-intensive devices and applications. The company was acquired by Qualcomm in March 2021.

2

Funding Rounds

$293.0m

Money raised

Splinterlands logo

Splinterlands

Splinterlands is a digital trading card game built on blockchain technology.

2

Funding Rounds

$3.6m

Money raised

Ondo Finance logo

Ondo Finance

Ondo Finance is an open, permissionless, decentralized investment bank

2

Funding Rounds

$24.0m

Money raised

Mysten Labs logo

Mysten Labs

Mysten Labs creates foundational infrastructure to accelerate the adoption of Web3.

2

Funding Rounds

$336.0m

Money raised

Bitmain logo

Bitmain

Bitmain is a Beijing-based multinational semiconductor company, founded in 2013, that manufactures products for blockchain and artificial intelligence (AI) applications.

3

Funding Rounds

$764.7m

Money raised

ShapeShift logo

ShapeShift

A web and API platform that provides Bitcoin and Altcoin conversion.

3

Funding Rounds

$2.3m

Money raised

Rigetti Computing logo

Rigetti Computing

Rigetti Computing is a quantum computing company based in Berkeley, California.

10

Funding Rounds

$269.5m

Money raised

CUJO AI logo

CUJO AI

CUJO AI is a network intelligence software company.

4

Funding Rounds

$8.5m

Money raised

Perfect Day Foods logo

Perfect Day Foods

Perfect Day Foods (formerly Muufri) engineered yeast capable of producing the proteins found in cows milk. They use these proteins to make their own line of animal-free dairy products.

7

Funding Rounds

$711.5m

Money raised

ZETA logo

ZETA

Zeta Markets is the premier derivatives protocol on Solana.

1

Funding Rounds

$8.5m

Money raised

Kepler Communications logo

Kepler Communications

Kepler Communications is a company that has a focus on satellite production and communication networks.

7

Funding Rounds

$81.3m

Money raised

Superhuman logo

Superhuman

A company offering an email client designed to be the fastest email experience. The company was founded by Conrad Irwin, Rahul Vohra, and Vivek Sodera in 2015 and is headquartered in San Francisco, California.

5

Funding Rounds

$121.0m

Money raised

TrustArc logo

TrustArc

TrustArc is a San Francisco-based developer of privacy compliance and risk management software for GDPR, CCPA, and related regulations.

4

Funding Rounds

$107.0m

Money raised

Boundless (company) logo

Boundless (company)

Boundless is a Seattle-based company offering immigrants tools, information, and personalized support to facilitate their immigration journey.

5

Funding Rounds

$45.8m

Money raised

Mighty Buildings logo

Mighty Buildings

Mighty Buildings is a company working in the construction industry with 3D printing technology and advanced composite materials, funded by Y Combinator.

6

Funding Rounds

$97.8m

Money raised

BluVector logo

BluVector

BluVector is a developer of an AI-based solution to deliver advanced threat detection and network coverage for enterprises.

1

Funding Rounds

DataRobot logo

DataRobot

DataRobot sells a machine learning platform that helps users build and deploy accurate predictive models. The Boston-based company was founded in 2012 by Jeremy Achin.

10

Funding Rounds

$1.0b

Money raised

Exabeam logo

Exabeam

Exabeam is a San Mateo, California-based data security analytics company offering cybersecurity and early cyber attack detection software.

8

Funding Rounds

$390.0m

Money raised

New Wave Foods logo

New Wave Foods

New Wave Foods is a biotechnology company developing plant-based shellfish food products. The company is based out of San Francisco, California and was founded in 2015 by Dominique Barnes and Michelle Wolf.

9

Funding Rounds

$20.3m

Money raised

Praxis Society logo

Praxis Society

Praxis is a membership-based community of creatives and technologists building a city-cryptostate.

2

Funding Rounds

$19.2m

Money raised

PathAI (company) logo

PathAI (company)

PathAI is a Boston-based artificial intelligence company developing therapeutics and healthcare products.

5

Funding Rounds

$390.0m

Money raised

HYPRES logo

HYPRES

HYPRES is a developer of superconducting microelectronics for defense, wireless, and optical network industries.

1

Funding Rounds

$50.0k

Money raised

AppZen logo

AppZen

AppZen is a San Jose, California-based company that provides an AI-based auditing platform for finance teams.

6

Funding Rounds

$100.9m

Money raised

Tempus Labs (company) logo

Tempus Labs (company)

Tempus, a technology company advancing precision medicine through the practical application of artificial intelligence in healthcare.

10

Funding Rounds

$930.0m

Money raised

Cake DeFi logo

Cake DeFi

Cake is an all-in-one decentralized finance (DeFi) platform.

1

Funding Rounds

$2.4m

Money raised

Finless Foods logo

Finless Foods

Finless Foods is a biotechnology company producing cultured marine animal food products through implementing cellular agriculture and manufacturing technologies.

9

Funding Rounds

$37.5m

Money raised

Just, Inc. logo

Just, Inc.

Just, Inc. (formerly known as Hampton Creek) is a food technology company developing and selling plant based food products around the world.

8

Funding Rounds

$220.0m

Money raised

Hypergiant Industries logo

Hypergiant Industries

Hypergiant Industries is a machine learning and artificial intelligence company offering client-focused services and research and development in various fields. The company was founded by Ben Lamm and John Fremont in 2018.

2

Funding Rounds

Openpath Security Inc. logo

Openpath Security Inc.

Openpath Security Inc. is a Culver City, California-based cybersecurity company offering mobile and cloud-enabled access control systems.

3

Funding Rounds

$63.0m

Money raised

Wise logo

Wise

Wise, previously TransferWise, is a company that offers money transfers services founded by Kristo Käärmann and Taavet Hinrikus.

6

Funding Rounds

$898.4m

Money raised

Socure logo

Socure

Socure is a New York City-based developer of an identity verification and fraud risk solution.

8

Funding Rounds

$646.9m

Money raised

ItBit logo

ItBit

ItBit is a platform for institutions and active investors to trade cryptocurrency assets.

1

Funding Rounds

$3.3m

Money raised

Eat Just logo

Eat Just

Eat Just is a San Francisco based food technology company founded in 2011. The company is known for its bean-based egg substitute called Just Egg. Eat Just also produces egg-free mayonnaise.

8

Funding Rounds

$551.0m

Money raised

Upside Foods logo

Upside Foods

Upside Foods is a San Francisco-based company making cultured meat products. The company was founded by Uma Valeti, Nicholas Genovese, and Will Clem.

4

Funding Rounds

$580.8m

Money raised

Grail logo

Grail

Grail is a biotechnology company headquartered in Menlo Park, California that was founded as a spinoff of Illumina Inc and initially headed by Jeffrey Huber in 2016, focused on making a medical device that can detect early stage cancer.

4

Funding Rounds

$1.8b

Money raised

SynFutures logo

SynFutures

SynFutures is a decentralized Derivatives Protocol.

3

Funding Rounds

$15.4m

Money raised

MixMob logo

MixMob

P2E game build on Solana blockchain. Grab your mask and start your journey - level up from card strategy battle game to full MMO glory!

2

Funding Rounds

$7.0m

Money raised

Anduril Industries logo

Anduril Industries

Anduril builds AI platforms to protect troops, fight wildfires, perform search & rescue missions, and provide border surveillance. It was founded in 2017 and is located in Irvine, California.

7

Funding Rounds

$2.2b

Money raised

Apeel Sciences logo

Apeel Sciences

Apeel Sciences is a company that develops treatments to prevent spoilage of fruits and vegetables using molecules naturally found in peels, which maintain moisture and keep out oxygen.

21

Funding Rounds

$1.9b

Money raised

O3 Labs logo

O3 Labs

O3 Labs is a Japanese startup that offers a range of cryptocurrency services for an undisclosed price.

1

Funding Rounds

$2.0m

Money raised

Distil Networks logo

Distil Networks

Distil Networks was an American cybersecurity company founded in 2011 and headquartered in San Francisco, California.

3

Funding Rounds

$22.8m

Money raised

BTC-Alpha logo

BTC-Alpha

BTC-Alpha is a cryptocurrency exchange platform.

Grove Collaborative logo

Grove Collaborative

Grove Collaborative is an online, subscription-based retailer selling natural home and health products.

4

Funding Rounds

$477.4m

Money raised

Primitive Finance logo

Primitive Finance

Primitive - Crypto derivative products built on the Replicating Market Maker protocol, an oracle-free solution to scalable and efficient on-chain derivatives.

1

Funding Rounds

$9.0m

Money raised

Catalog logo

Catalog

Catalog is a Boston, Massachusetts-based company developing a platform for DNA-based digital data storage.

7

Funding Rounds

$63.3m

Money raised

UBiome logo

UBiome

UBiome was a biotechnology microbial genomics company based in San Francisco.

8

Funding Rounds

$111.4m

Money raised

Blue Hexagon logo

Blue Hexagon

Blue Hexagon is a San Francisco-based cybersecurity company offering an on-device machine learning based malware detection product.

2

Funding Rounds

$37.0m

Money raised

Deel (company) logo

Deel (company)

Deel is a technology company offering a human resources management system solution for businesses working with global remote contractors.

10

Funding Rounds

$1.1b

Money raised

Currency.com logo

Currency.com

Regulated crypto exchange. Built the world's first regulated tokenised assets platform. It aims to revolutionise cryptocurrency investment.

1

Funding Rounds

$8.0m

Money raised