60 Best Synthetic Chemistry Startups to Watch in 2025

The Definitive Seedtable Ranking of Synthetic Chemistry Startups

We track 71,000+ companies and rank them dynamically using our Seedtable Score – a score that uses quantitative and qualitative data points to signal the momentum behind a company. We then monitor the list manually leveraging our expertise as founders and investors.

There are 60 start-ups with an aggregate funding of $9.9b. The average funding per company in this subset is $165.5m.

Last update to the database: Feb 18, 2025. See changelog.

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5

Funding Rounds

$72.2m

Money raised

Arzeda is a biotechnology and software company designing custom microorganisms for industrial applications through computational enzyme design, protein optimization, and metabolic engineering.

Key people:

8

Funding Rounds

$406.4m

Money raised

Bolt Threads is a biotechnology company that makes high performance fabrics and materials using biology.

21

Funding Rounds

$1.9b

Money raised

Apeel Sciences is a company that develops treatments to prevent spoilage of fruits and vegetables using molecules naturally found in peels, which maintain moisture and keep out oxygen.

3

Funding Rounds

$14.3m

Money raised

Aria Pharmaceuticals is a first-in-class pharmaceutical discovery and development founded in 2014 by Andrew M. Radin.

10

Funding Rounds

$635.4m

Money raised

Genomatica is a San Diego-based company founded in 2000 by Christophe Schilling.

Location:

Key people:

4

Funding Rounds

$87.8m

Money raised

DNA synthesis company using enzymatic DNA synthesis based in San Francisco.

5

Funding Rounds

$32.5m

Money raised

Fortify is a Boston-based 3D printing company that has the goal to enable fabrication of composites with optimized microstructures

10

Funding Rounds

$402.1m

Money raised

Genapsys is a company developing DNA sequencing technologies and systems founded in 2010 by Hesaam Esfandyarpour.

Key people:

4

Funding Rounds

$364.1m

Money raised

Dewpoint Therapeutics is a US-based drug manufacturing company.

4

Funding Rounds

$226.0m

Money raised

Arrakis is developing RNA-targeted small molecule (rSM) therapies to millions of patients.

1

Funding Rounds

$1.5m

Money raised

Cayman Chemical Company is an Ann Arbor, Michigan-based biotechnology company manufacturing healthcare and research diagnostic tools including assay kits, antibodies, proteins, and biochemicals.

Key people:

2

Funding Rounds

$53.0m

Money raised

Engine Biosciences is a San Francisco-based AI company that is focused on drugs development.

Key people:

4

Funding Rounds

$249.5m

Money raised

Boundless Bio is a pioneer in understanding and treating the most intractable cancers. They have charted a new spatial map of the cancer genome within cancer cells and are harnessing their scientific founders' discoveries about "extrachromosomal DNA," or ecDNA, to drive a revolution in cancer therapeutics.

1

Funding Rounds

$10.0m

Money raised

Contraline is a company developing contraceptive for men founded in 2015 by Kevin Eisenfrats.

2

Funding Rounds

$29.5m

Money raised

Empirico Inc. comprises of biologists, physicians, chemists, data scientists and drug developers whose focus is on transforming patients' lives with innovative therapies.

Key people:

3

Funding Rounds

$123.9m

Money raised

BioAge Labs focuses on developing AI and systems biology-based solutions for slowing the aging process and treating age-related illnesses.

Key people:

3

Funding Rounds

$108.9m

Money raised

Casma Therapeutics is a company that has a research community and uses its understanding of research to develop novel therapeutics to capture disease causing targets.

3

Funding Rounds

$34.5m

Money raised

GenEdit develops technology for gene editing.

Key people:

4

Funding Rounds

$223.5m

Money raised

A biotechnology company developing drugs for the treatment of metabolic diseases, cancer and inflammation

2

Funding Rounds

$53.0m

Money raised

DiaCarta is a Richmond, California-based molecular diagnostics company developing products for translational genomics and personalized diagnostics founded in 2011 by Aiguo Zhang.

3

Funding Rounds

$294.0m

Money raised

Cellarity is a company that develops medicines by understanding cell behaviors.

7

Funding Rounds

$40.6m

Money raised

Avitide discovers, develops, manufactures, and supplies custom and catalog biopharmaceutical affinity purification solutions to the biopharmaceutical industry.

Key people:

2

Funding Rounds

$140.0m

Money raised

Small molecule compounds that act by unlocking protein-protein interfaces

4

Funding Rounds

$69.9m

Money raised

A company that develops molecular imaging agents to detect and monitor chronic human diseases

2

Funding Rounds

$20.0m

Money raised

A company that provides services and technologies for the development and commercialization of biopharmaceutical products

6

Funding Rounds

$799.0m

Money raised

Small Molecules Acting on Stem Cells. Biosplice Therapeutics is in the medical research and development for tissue-level regeneration.

2

Funding Rounds

$3.0m

Money raised

Ceres Nanosciences is a sample Prep Technology founded in 2008.

3

Funding Rounds

$331.0m

Money raised

Aktis Oncology is a biotechnology company discovering and developing a novel class of targeted radiopharmaceuticals.

7

Funding Rounds

$58.8m

Money raised

Centrillion Technologies is a company that develops genomic and bioinformatic tools and services that analyze technology for personalized medicine and life sciences research.

Key people:

1

Funding Rounds

$3.0m

Money raised

A company developing application-specific coatings and medical devices for the orthopedic and cardiovascular fields

2

Funding Rounds

$135.3m

Money raised

Expansion Therapeutics is a RNA Targeted Small Molecules founded in 2016.

3

Funding Rounds

$351.0m

Money raised

FogPharma creates a new class of medicines that target human disease drivers currently considered undruggable.

4

Funding Rounds

$312.5m

Money raised

Escient Pharmaceuticals is a GPCR-targeted Drugs founded in 2018.

2

Funding Rounds

$666.0m

Money raised

Eikon Therapeutics is developing a new method of drug discovery based on tracking and measuring the movement of individual proteins in live cells.

2

Funding Rounds

$16.8m

Money raised

BCD Bioscience is a Davis, California-based biotechnology company developing ingredients for food, agriculture, and biopharmaceutical applications.

Key people:

1

Funding Rounds

$65.0m

Money raised

Cygnal Therapeutics is an exoneural biology company.

Key people:

2

Funding Rounds

$5.7m

Money raised

Apostle Inc is a Sunnyvale, California-based company providing technologies and services for public health and life sciences.

Key people:

4

Funding Rounds

$256.2m

Money raised

Cedilla Therapeutics is a company founded in 2018.

3

Funding Rounds

$34.5m

Money raised

A company focused on developing products for oncology surgery and therapeutic intervention

2

Funding Rounds

$2.5m

Money raised

Ascribe Bioscience develops products that enable farmers to combat crop pathogens without negative impacts on the environment.

2

Funding Rounds

$291.0m

Money raised

Element Biosciences is a genetic analysis tools.

2

Funding Rounds

$103.0m

Money raised

Accent Therapeutics is a RNA-modifying protein inhibitors founded in 2017 by Robert Copeland.

2

Funding Rounds

$92.2m

Money raised

Small molecule cancer drugs that stabilize the direct interaction of oncogenic proteins with the 14-3-3 class of adaptor proteins

1

Funding Rounds

$40.0m

Money raised

DeepCure is an AI Drug Discovery founded by Joseph Jacobson, Kfir Schreiber and Thrasyvoulos (Thras) Karydis.

Location:

Key people:

2

Funding Rounds

$34.1m

Money raised

BrightVolt is a Redmond, Washington-based company.

1

Funding Rounds

$140.0m

Money raised

Ambys Medicines is a liver cell, gene, drug therapies founded in 2018.

1

Funding Rounds

$12.0m

Money raised

BridGene Biosciences is a small molecules that drug traditionally undruggable targets.

1

Funding Rounds

$75.0m

Money raised

ADARx is developing a RNA targeting platform focused on genetic, cardiometabolic and central nervous system diseases

3

Funding Rounds

$10.2m

Money raised

Celsee Diagnostics is a Plymouth, Michigan-based diagnostics company developing single-cell and liquid biopsy products.

2

Funding Rounds

$95.0m

Money raised

Blade Therapeutics is a fibrosis Treatments.

1

Funding Rounds

$78.0m

Money raised

Exo Therapeutics is a small Molecule Drug Discovery.

1

Funding Rounds

$6.8m

Money raised

2

Funding Rounds

$80.0m

Money raised

Anokion is an immune-tolerated therapeutic proteins founded by Melody Swartz.

1

Funding Rounds

$30.0m

Money raised

Anagenex is a directed Evolution Platform for Small Molecule Discovery founded in 2019.

1

Funding Rounds

$10.0m

Money raised

Boragen is a United States-based company.

1

Funding Rounds

$53.0m

Money raised

Civetta Therapeutics is a small molecule targeting of beta-propeller domains founded in 2019.

1

Funding Rounds

$3.3m

Money raised

DeTect is a company founded by Hugo Barra.

Location:

Key people:

1

Funding Rounds

$76.0m

Money raised

Autobahn Therapeutics is a remyelination program for multiple sclerosis.

1

Funding Rounds

$4.5m

Money raised

Advenchen Laboratories is a small Molecules founded in 2003.

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