69 Best Startups in San Antonio to Watch in 2025

The Definitive Seedtable Ranking of Startups in San Antonio

We track 71,000+ companies and rank them dynamically using our Seedtable Score – a score that uses quantitative and qualitative data points to signal the momentum behind a company. We then monitor the list manually leveraging our expertise as founders and investors.

There are 81 start-ups with an aggregate funding of $1.1b. The average funding per company in this subset is $15.4m.

Last update to the database: Feb 18, 2025. See changelog.

See all results for this search

Track over 71,000 companies

Discover
Fast-growing Global startups

Seedtable uses technology and people to track over 71,000 companies to help you find the right ones to partner with.

Pricing + Sign up

7

Funding Rounds

$102.9m

Money raised

Xenex Disinfection Services is a company that provides pulsed xenon ultraviolet-C, room disinfection systems to healthcare facilities

7

Funding Rounds

$38.0m

Money raised

Import.io is a Los Gatos, California-based company founded in 2012 by David White that extracts data from websites.

1

Funding Rounds

$1.5m

Money raised

StemBioSys is a biotechnology company developing regenerative medicines using stem cells.

3

Funding Rounds

$5.5m

Money raised

Scripted is a company founded in 2011.

1

Funding Rounds

$2.5m

Money raised

Targazyme is a biotechnology company focused on improving survival and quality of life for cancer patients using stem cell transplantation, immunotherapy, regenerative medicine, and gene therapy.

5

Funding Rounds

$85.0m

Money raised

Plus One Robotics focuses on the development of robotic systems that are scalable, flexible, and fault-tolerant.

3

Funding Rounds

$51.1m

Money raised

MailGun is a company providing APIs for developers for integrating emails into applications.

2

Funding Rounds

$140.0m

Money raised

Scaleworks is a company that invests in and acquires B2B SaaS products.

2

Funding Rounds

$1.8m

Money raised

Formerly Filepicker.io, Filestack is a company providing a Software-as-a-Service solution to help software developers in content management.

2

Funding Rounds

$840.3k

Money raised

ParLevel Systems is a company founded in 2013 by Walter Teele Vera, Rafael Barroso, Luis P Gonzalez, Alan Munson, Gabriel Senior and Alfonso García.

1

Funding Rounds

$5.0k

Money raised

Veradermics, Inc. is a medical dermatology company advancing first-in-class therapeutics that address real-world patient needs in under-innovated dermatology markets.

3

Funding Rounds

$15.5m

Money raised

Earth Class Mail is a San Antonio-based company.

2

Funding Rounds

$2.8m

Money raised

TrueAbility is a San Antonio-based company founded in 2012 by Dusty Jones, Frederick Mendler, Marcus Robertson and Luke Owen.

1

Funding Rounds

Denim Group provides enterprise application security consultants offering threat assessment and vulnerability remediation services.

4

Funding Rounds

$1.2m

Money raised

Irys, formerly known as CItyFlag, is a San Antonio, Texas based company developing government software and civic technologies.

Location:

3

Funding Rounds

$9.0m

Money raised

H4 Engineering Inc. is an engineering company that is based in San Diego.

1

Funding Rounds

$1.5m

Money raised

FunnelAI is a San Antonio, Texas-based customer relationship management, lead generation, and lead management company.

1

Funding Rounds

$833.8k

Money raised

Medcognition, Inc. is a San Antonio-based company focused on holographic patient simulation technology

2

Funding Rounds

SafeRide Health is a company founded in 2016.

1

Funding Rounds

$850.0k

Money raised

Akimbo Card is a San Antonio-based company founded in 2010 by Houston Frost, Todd Mayberry, Tom O. Turner, Matthew Decker and Garrett Cox.

2

Funding Rounds

$19.9m

Money raised

FloatMe is a San Antonio-based company founded in 2020 by Joshua Sanchez, Christopher Brown and Ryan Cleary.

1

Funding Rounds

$375.0k

Money raised

Assembla is a company founded in 2005.

Location:

1

Funding Rounds

$30.0m

Money raised

Incube Labs is a company providing clinical research services founded in 1995.

2

Funding Rounds

$6.2m

Money raised

CyberFortress is a company offering cyber insurance for small businesses founded in 2018 by Huw Edwards, Michael DeFelice and Nate Shames.

1

Funding Rounds

$14.7m

Money raised

Keen IO is a San Antonio-based software as a service company founded in 2011.

1

Funding Rounds

$1.2m

Money raised

Reckon Point is an artificial Intelligence company founded in 2015 by Gabe Garza.

2

Funding Rounds

$4.2m

Money raised

bioAffinity Technologies is a San Antonio-based medical diagnostics company developing early cancer detection technologies.

1

Funding Rounds

$39.0m

Money raised

Seno Medical Instruments is a San Antonio-based medical diagnostics company developing opto-acoustic imaging systems for cancers.

1

Funding Rounds

$10.0k

Money raised

Olifant Medical is a San Antonio, Texas-based company producing the TUSK Trachael Cannulator, a medical device meant to help medical professionals insert endotrachael tubes faster and more safely.

1

Funding Rounds

$20.8m

Money raised

Manufacturer of Polyzene-F nanocoating technology-based medical devices and products intended for the treatment of cardiovascular disease and addressing the treatment gap in patients at high risk of bleeding.

4

Funding Rounds

$12.5m

Money raised

A podcast platform that allows podcasters to livestream and interact with their listeners in real time.

2

Funding Rounds

$4.8m

Money raised

A wound care technology company developing wound care and monitoring systems

1

Funding Rounds

$200.0k

Money raised

Pear Analytics is a San Antonio-based company founded in 2008.

6

Funding Rounds

$23.0m

Money raised

Vascular Perfusion Solutions, Inc. is an oxygenated perfusion cardiac transport device founded in 2016.

1

Funding Rounds

$13.7m

Money raised

WellAware Holdings is a San Antonio-based company founded in 2012.

1

Funding Rounds

New Dominion Enterprises is a San Antonio-based company founded by Jay Fraser.

Industries:

Location:

1

Funding Rounds

$105.0m

Money raised

3

Funding Rounds

$31.5m

Money raised

Renu Robotics Corp is a San Antonio-based company founded in 2018.

Location:

1

Funding Rounds

$3.0m

Money raised

Nextgenid is a company founded in 1999.

2

Funding Rounds

$10.3m

Money raised

A biopharmaceutical company developing botanical pharmaceuticals for the treatment of human papillomavirus infections

2

Funding Rounds

$9.1m

Money raised

GenSpera is an oncology company developing therapeutics targeting tumors founded in 2003 by Richard Burgoon.

Location:

Key people:

4

Funding Rounds

$17.7m

Money raised

Transect, Inc. is a San Antonio-based company founded in 2020.

Location:

1

Funding Rounds

$4.4m

Money raised

Territorium is a San Antonio-based company founded in 2012 by Guillermo Elizondo.

10

Funding Rounds

$19.1m

Money raised

ELECTROCHEMICAL OXYGEN CONCEPTS INC is a San Antonio-based company.

Location:

1

Funding Rounds

$9.0m

Money raised

Skyonic is a San Antonio-based company.

Location:

1

Funding Rounds

$370.0k

Money raised

A company developing electronic resource tools for health care providers

1

Funding Rounds

$1.0m

Money raised

1

Funding Rounds

$15.0m

Money raised

Palace Way LP is a real estate development company founded in 2019.

2

Funding Rounds

$4.3m

Money raised

Turn Medical, LLC is a San Antonio-based company founded in 2018.

Location:

2

Funding Rounds

$5.3m

Money raised

Innovative Trauma Care is a San Antonio-based company founded in 2010.

Location:

3

Funding Rounds

$20.0m

Money raised

Dura Software, Inc. is a San Antonio-based company founded in 2019.

Location:

2

Funding Rounds

MyToons is a San Antonio-based company.

Location:

1

Funding Rounds

$10.0m

Money raised

Ranger Health, Inc. is a San Antonio-based healthcare company founded in 2015.

Industries:

Location:

4

Funding Rounds

$7.4m

Money raised

PHOENIX BIOTECHNOLOGY INC is a San Antonio-based company.

Location:

1

Funding Rounds

$294.0k

Money raised

Comfort Surgery Center of San Antonio, LLC is a San Antonio-based company founded in 2019.

Location:

1

Funding Rounds

$4.5m

Money raised

Wellvana is a San Antonio-based company.

3

Funding Rounds

$3.6m

Money raised

XComP Analytics, Inc. is a San Antonio-based company founded in 2017.

Location:

1

Funding Rounds

$1.0m

Money raised

Bright Bucks, Inc. is a San Antonio-based company founded in 2019.

Location:

2

Funding Rounds

$34.0m

Money raised

WGVS Holdings, LLC is a San Antonio-based company founded in 2017.

Location:

1

Funding Rounds

$2.0m

Money raised

OneModel 2019 Series of Geekdom Fund Sidecar Series LLC is a San Antonio-based company founded in 2019.

Location:

1

Funding Rounds

$250.0k

Money raised

Hera Biotech, Inc. is a San Antonio-based company founded in 2020.

1

Funding Rounds

$3.0m

Money raised

Infotouch Corp. is a San Antonio-based business development company founded in 1986.

Industries:

Location:

1

Funding Rounds

$420.9k

Money raised

Tenfold SPV 2019 Series of Geekdom Fund Sidecar Series LLC is a San Antonio-based company founded in 2019.

Location:

1

Funding Rounds

$1.5m

Money raised

Synergy Capital Group LLC is a San Antonio-based company founded in 2019.

Location:

1

Funding Rounds

$1.0

Money raised

Estia, Inc. is a San Antonio-based company founded in 2015.

Location:

1

Funding Rounds

$30.0m

Money raised

Blue Duck Express, Inc. is a San Antonio-based company founded in 2018.

Location:

1

Funding Rounds

$800.0k

Money raised

Ira Avenue Lofts, LLC is a San Antonio-based company founded in 2019.

Location:

2

Funding Rounds

$51.5m

Money raised

AirStrip Technologies, Inc. is a San Antonio-based company.

Location:

1

Funding Rounds

$5.0m

Money raised

AIU Alternative Care, Inc. is a San Antonio-based company founded in 2019.

Location:

Sign up to access our full database

Enter your email and get access to 71,000 + technology companies you can partner with.

Join 29000+ founders, operators, and investors.