67 Best Startups in Chicago to Watch in 2025

The Definitive Seedtable Ranking of Startups in Chicago

We track 71,000+ companies and rank them dynamically using our Seedtable Score – a score that uses quantitative and qualitative data points to signal the momentum behind a company. We then monitor the list manually leveraging our expertise as founders and investors.

There are 753 start-ups with an aggregate funding of $11.7b. The average funding per company in this subset is $174.5m.

Last update to the database: Feb 18, 2025. See changelog.

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10

Funding Rounds

$930.0m

Money raised

Tempus, a technology company advancing precision medicine through the practical application of artificial intelligence in healthcare.

7

Funding Rounds

$638.8m

Money raised

TradingView is a platform which provides instruments for publication and the viewing of trading ideas.

Key people:

7

Funding Rounds

$99.0m

Money raised

NOCD provides online therapy for obsessive-compulsive disorder (OCD).

6

Funding Rounds

$80.5m

Money raised

Hologram is a company with a platform for building Internet of Things type products

Key people:

9

Funding Rounds

$852.6m

Money raised

Fetch Rewards is a mobile shopping platform for earning points and rewards on purchases.

Key people:

10

Funding Rounds

$407.9m

Money raised

Kin Insurance is an insurance technology company offering home insurance founded in 2016.

3

Funding Rounds

$58.0m

Money raised

Arturo.ai is a Chicago-based insurance technology and artificial intelligence company.

5

Funding Rounds

$9.7m

Money raised

Avail is a Chicago-based company developing free landlord software to help with rental property management.

4

Funding Rounds

$73.0m

Money raised

Wickr is a telecommunications and security company that builds secure communication tools, such as a messaging application. It was founded in 2012 and is located in San Francisco, California.

Key people:

8

Funding Rounds

$1.3b

Money raised

ShipBob is a company offering logistics services to small- to mid-sized businesses.

Location:

Key people:

11

Funding Rounds

$908.0m

Money raised

Project44 is a visibility platform for shippers and third-party logistics firms tracking the supply chain.

3

Funding Rounds

$36.0m

Money raised

Fingerprint is a developer of an application programming interface designed for fraud detection on the modern web.

Location:

Key people:

4

Funding Rounds

$73.0m

Money raised

An insurance technology company offering a platform for insurance claims.

7

Funding Rounds

$169.9m

Money raised

Zero Hash is a financial services company specializing in digital assets-as-a-service technology.

8

Funding Rounds

$851.0m

Money raised

Nature's Fynd is a biotechnology company growing edible proteins founded in 2012.

2

Funding Rounds

$11.5m

Money raised

An artificial intelligence company with a focus on developing solutions for the healthcare industry. It was founded in 2017 and is located in Tel Aviv, Israel.

Industries:

Location:

Key people:

6

Funding Rounds

$133.4m

Money raised

Common is a NYC-based coliving company founded by Brad Hargreaves founded in 2015 by Brad Hargreaves.

4

Funding Rounds

$8.6m

Money raised

Popular Pays is company providing a platform connecting brands with creators to produce custom content and generate awareness.

1

Funding Rounds

$2.5m

Money raised

LotLinx is a marketing technology suite used in the American and Canadian automotive industry. It is an automotive VIN-specific digital marketing suite.

Location:

Key people:

2

Funding Rounds

$37.0m

Money raised

Fly.io is a Chicago-based platform for deploying full stack application servers and databases close to users.

Location:

Key people:

6

Funding Rounds

$67.8m

Money raised

Fast Radius is a Chicago, IL-based Mechanical and Industrial Engineering company.

Key people:

3

Funding Rounds

$7.1m

Money raised

EarlyBird is a platform for parents looking to invest for their children.

Industries:

Location:

Key people:

2

Funding Rounds

$12.0m

Money raised

Wellspring Worldwide is an innovation and technology commercialization program that offers technology scouting, corporate venturing, licensing and intellectual property software for corporations and universities.

Location:

Key people:

3

Funding Rounds

$359.0m

Money raised

Avant is a company operating an online platform providing users access to personal loans. It utilizes big data and machine learning algorithms.

Location:

Key people:

3

Funding Rounds

$30.0m

Money raised

Instana is a SaaS-based application performance management (APM) platform based in Chicago, Illinois and in the Ohligs borough of Solingen, Germany.

6

Funding Rounds

$6.8m

Money raised

Venzee is a software development company based in Vancouver, Canada. The company offers a cloud-based AI platform for online retailers and vendors.

1

Funding Rounds

$2.5m

Money raised

BiomeSense, Inc. is a biotechnology company developing microbiome technologies for the collection, storage, and analysis of gut microbiome profiles.

Key people:

4

Funding Rounds

$325.9m

Money raised

Clearcover is a smarter car insurance choice. We deliver the right coverage, when it matters, so you can pay less. Clearcover saves you money by applying advanced technology and only talking to you about insurance in moments that matter - like when you're buying a car, shopping for better insurance rates or managing your finances. With Clearcover, you get the same great coverage as Big Insurance, for up to 40% less per month. Follow along with our progress on Medium: https://medium.com/@ClearcoverInc or on Twitter @Clearcover

Key people:

1

Funding Rounds

$2.1m

Money raised

Elixir is a company that has developed a protocol for decentralized finance.

Location:

Key people:

3

Funding Rounds

$455.0m

Money raised

A developer of primary care clinics. VillageMD provides support services to physicians and to patients outside the office visit with aim of better clinical outcomes and enhanced patient experience.

Location:

Key people:

1

Funding Rounds

$15.0m

Money raised

Seed CX is a cryptocurrency company founded in 2017 by Brian Liston.

4

Funding Rounds

$4.9m

Money raised

Draftbit is a company that gives the option to build a cross-platform, native iOS and Android app.

5

Funding Rounds

$343.0m

Money raised

Uptake is a SaaS company that works with industrial companies to analyze and predict equipment performance.

Location:

Key people:

3

Funding Rounds

$7.5m

Money raised

Next Big Sound provides a dashboard, charts, and reports to monitor popularity, activity, and metrics for musicians, albums, authors and books across social media, sales and events.

5

Funding Rounds

$410.8m

Money raised

Copado is a provider of a DevOps platform for Salesforce users.

Location:

1

Funding Rounds

$2.5m

Money raised

GFX Labs is a technology company with a focus on developing decentralized finance products.

3

Funding Rounds

$360.0m

Money raised

ActiveCampaign provides a platform with email marketing, marketing automation, and CRM tools for small-to-mid-sized businesses.

Location:

Key people:

3

Funding Rounds

$770.0k

Money raised

Peeranha is a question and answer (Q & A) website that rewards users with cryptocurrency.

Location:

Key people:

4

Funding Rounds

$64.0m

Money raised

A company offering a compliance platform for marketing cannabis products.

1

Funding Rounds

$10.0m

Money raised

BlueCart is an online ordering platform that connects wholesale suppliers and buyers in the hospitality industry.

4

Funding Rounds

$3.1m

Money raised

A technology company providing a commercial real estate asset management platform.

Key people:

7

Funding Rounds

$399.0m

Money raised

Flock Freight is a Solana Beach, California-based company that uses algorithmic pooling technology to allow less-than-truckload (LTL) shippers to share trailer space in one full truckload.

12

Funding Rounds

$218.2m

Money raised

SPOTHERO, INC. is a Chicago-based company founded in 2011 by Mark Lawrence.

Location:

Key people:

6

Funding Rounds

$48.5m

Money raised

Software to power reservations, tickets, order delivery and pickup from restaurants.

1

Funding Rounds

$120.0k

Money raised

A technology company provides an artificial intelligence-powered operational system for real estate developers and agents.

Key people:

4

Funding Rounds

$38.4m

Money raised

Livly is an AI-powered property management software company that simplifies apartment community operations, enhances resident experiences, and predicts lease renewals with AI tools and digital rewards.

Location:

Key people:

4

Funding Rounds

$141.5m

Money raised

FarEye is a Chicago-based company offering a delivery management platform for retail, e-commerce, and third party logistics companies.

2

Funding Rounds

$9.2m

Money raised

Opternative is a series B startup that offers an online vision test to get a prescription for glasses and contacts from an ophthalmologist.

3

Funding Rounds

$1.3m

Money raised

Food Genius is a Chicago-based company founded in 2010 by Justin Massa, Eli Rosenburg and Benjamin Stanley.

2

Funding Rounds

$249.1m

Money raised

A financial services company offering a searchable platform for buy-side investors to access qualitative investment research.

Location:

Key people:

6

Funding Rounds

$178.0m

Money raised

SilkRoad Technology is a Chicago-based company founded in 2003 by Andrew Filipowski.

5

Funding Rounds

$405.0m

Money raised

SMS Assist is a company providing exterior maintenance, facilities maintenance, interior maintenance, and property management services.

4

Funding Rounds

$60.8m

Money raised

Tovala is a Chicago-based startup company marketing a countertop steam oven that comes with a meal kit subscription service.

Location:

Key people:

1

Funding Rounds

$2.2m

Money raised

A blockchain company offering a platform for making alternative investments.

Key people:

7

Funding Rounds

$43.4m

Money raised

RedShelf is a company. It provides an HTML5 cloud reader and marketplace to buy, sell and read eBooks, textbooks, academic materials, magazines, documents and other digital content.

Location:

Key people:

1

Funding Rounds

$410.0k

Money raised

Rise Interactive is a digital marketing company founded in 2004.

5

Funding Rounds

$71.7m

Money raised

Twaice delivers solutions based on digital twins to reduce battery development and testing costs as well as to increase battery reliability and lifetime.

3

Funding Rounds

$40.0m

Money raised

Paro is creating the future of finance work by empowering people to do what they love. Paro matches businesses of all sizes and industries with highly vetted financial analysts, CFOs, CPAs, and bookkeepers who have the domain expertise to tackle company-specific problems on an on-demand, hourly basis. Only the top 2% of finance freelancers make it through our screening process so businesses are guaranteed top-notch experts at affordable prices.

Key people:

1

Funding Rounds

$2.0m

Money raised

taxProper is a technology company that monitors property taxes and automatically appeals when its clients are overcharged by the county assessor.

Industries:

Location:

Key people:

8

Funding Rounds

$278.2m

Money raised

Company

3

Funding Rounds

$8.7m

Money raised

YCharts is a Chicago-based company founded in 2009 by Ara Anjargolian.

2

Funding Rounds

$25.0m

Money raised

Jellyvision is a Chicago-based company founded in 1989 by Harry Gottlieb.

Location:

Key people:

3

Funding Rounds

$8.2m

Money raised

Packback is a company founded in 2014 by Nick Currier, Kasey Gandham, Jessica Tenuta and Mike Shannon.

Key people:

5

Funding Rounds

$102.5m

Money raised

Hazel Technologies is a biotechnology for foodwaste prevention company founded in 2015 by Patrick Flynn, Amy Garber and Adam Preslar.

Key people:

1

Funding Rounds

$3.8m

Money raised

MetaMe Health is a telemedicine and company founded in 2015 and headquartered in Chicago, Illinois offering a 6-session hypnosis treatment for Irritable Bowel Syndrome (IBS).

Location:

5

Funding Rounds

$155.9m

Money raised

LogicGate is a Chicago-based company founded in 2015 by Matt Kunkel, Jon Siegler and Dan Campbell.

Location:

Key people:

2

Funding Rounds

$2.8m

Money raised

Founded in 2012, reverb is the world's largest dedicated online marketplace for buying and selling new and used music gear.

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