69 Best Microbiome Startups to Watch in 2025

The Definitive Seedtable Ranking of Microbiome Startups

We track 71,000+ companies and rank them dynamically using our Seedtable Score – a score that uses quantitative and qualitative data points to signal the momentum behind a company. We then monitor the list manually leveraging our expertise as founders and investors.

There are 97 start-ups with an aggregate funding of $6.0b. The average funding per company in this subset is $86.4m.

Last update to the database: Feb 18, 2025. See changelog.

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8

Funding Rounds

$111.4m

Money raised

UBiome was a biotechnology microbial genomics company based in San Francisco.

6

Funding Rounds

$399.8m

Money raised

Human Longevity is a genomic-based, health intelligence company empowering proactive healthcare and enabling a life better lived.

Key people:

10

Funding Rounds

$635.4m

Money raised

Genomatica is a San Diego-based company founded in 2000 by Christophe Schilling.

Location:

Key people:

1

Funding Rounds

$300.0m

Money raised

BGI is a life science and genomics organization following a development model of research, production and application.

13

Funding Rounds

$386.6m

Money raised

A biotechnology company that develops medicines based on live bacterial consortia that can colonize the human intestine.

5

Funding Rounds

$68.7m

Money raised

AOBiome Therapeutics is a therapeutics company, based in Newton, Massachusetts and founded in 2013, that developed strains of Ammonia Oxidizing Bacteria (AOB) to administer live in treatments that address inflammatory conditions.

Key people:

8

Funding Rounds

$117.5m

Money raised

Locus Biosciences is a biotechnology company developing CRISPR-Cas3-engineered precision antibacterial products.

Key people:

9

Funding Rounds

$82.6m

Money raised

Biotherapeautics company founded in 2014 and based in Paris that uses proprietary methods in synthetic biology, protein and genome engineering to produce Eligobiotics, products which intervene with the microbiome as diagnostics, antimicrobials and modulators of host-microbiome interactions.

Location:

Key people:

5

Funding Rounds

$57.1m

Money raised

Metabolon is a company developing metabolomics analytical methods and software for biomarker discovery

1

Funding Rounds

$750.0k

Money raised

Nextbiotics is a biotechnology and synthetic biology company that leverages synthetic biology tools and bacteriophage technology to provide solutions to the antibiotic resistance crisis.

1

Funding Rounds

Roquette is a French company focused on the production of plant-based food and nutrition ingredients for the food, beverage and pharmaceutical industries. The company was founded in 1933 by Dominique & Germain Roquette, and is headquartered in Lestrem, Nord-Pas-De-Calais, France.

2

Funding Rounds

$645.0k

Money raised

CHAIN Biotechnology is a live biotherapeutics company founded in 2014 and based in Nottingham and Marlow, UK. CHAIN works with the Synthetic Biology Research Centre in Nottingham and has built a live biotherapeutic platform based on Clostridia to deliver bioactive molecules to treat diseases associated with the human gut microbiome.

2

Funding Rounds

$30.0m

Money raised

Siolta Therapeutics develops microbiome analyses to test microbial-based therapeutics for the treatment and prevention of inflammatory diseases. The company was founded in 2016 by Nikole Kimes PhD.

10

Funding Rounds

$62.4m

Money raised

A software solutions company providing bioinformatics solutions to life science and other sector

5

Funding Rounds

$125.0m

Money raised

Evolve Biosystems is a biotechnology company founded in 2012. The company develops microbiome-based products engineered to restore and maintain the gut microbiome.

Location:

Key people:

2

Funding Rounds

$100.0m

Money raised

Snipr Biome is a synthetic biology company using CRISPR to make products for the microbiome.

9

Funding Rounds

$56.6m

Money raised

A company based in Farmington, Connecticut, that develops skin disease treatments using microbiome science and technology.

Key people:

1

Funding Rounds

$2.5m

Money raised

BiomeSense, Inc. is a biotechnology company developing microbiome technologies for the collection, storage, and analysis of gut microbiome profiles.

Key people:

1

Funding Rounds

$400.0k

Money raised

Xycrobe Therapeutics is a biotechnology company developing microbiome-Based, biotherapeutic delivery systems.

14

Funding Rounds

$332.5m

Money raised

Enterome is a pharmaceutical company founded in 2012 by Pierre Belichard.

Location:

Key people:

2

Funding Rounds

$14.0m

Money raised

A biotechnology company using the environmental microbiome to verify the origin of goods in global supply chains.

8

Funding Rounds

$59.9m

Money raised

MaaT Pharma (Microbiota as a Therapy) is a French biotech start-up, created at the end of 2014, to treat diseases linked to imbalances in the intestinal microbiome.

7

Funding Rounds

$252.5m

Money raised

AgBiome is focused on the discovery and development of biological and trait products for crop production.

1

Funding Rounds

$12.0m

Money raised

Developing innovative therapies focused on microbiome gut-brain axis.

8

Funding Rounds

$1.2b

Money raised

Indigo is an agricultural technology company utilizing natural microbiology and digital technologies to improve farmers' profitability, environmental sustainability and consumer health.

6

Funding Rounds

$23.4m

Money raised

Biome Makers is a biotech start-up specializing in microbiome understanding to provide analysis for agricultural and industrial processes.

Key people:

1

Funding Rounds

$125.0k

Money raised

OpenBiome is a nonprofit stool bank. They provide stool preparations to clinicians for fecal microbiota transplantation.

Key people:

3

Funding Rounds

$20.8m

Money raised

Sun Genomics is a company developing personalized probiotics founded in 2016 by Sunny Jain.

Location:

Key people:

3

Funding Rounds

$11.1m

Money raised

Naked Biome is a microbiome-based therapeutics company founded in 2015 and headquartered in San Francisco, California making therapies to treat and prevent skin diseases and conditions.

Location:

Key people:

6

Funding Rounds

$116.0m

Money raised

Axial Therapeutics is a biopharmaceutical company targeting neurological disorders such as Parkinson's and Autism via gut health.

3

Funding Rounds

$67.5m

Money raised

Second Genome is a company that is developing microbiome modulators for infection, immunity and metabolic diseases.

Key people:

7

Funding Rounds

$1.4m

Money raised

Microbiome Insights is a microbiome services and bioinformatics company.

Key people:

2

Funding Rounds

$13.8m

Money raised

Animab is a Ghent-based biotechnology company developing products for livestock health.

Location:

Key people:

6

Funding Rounds

$6.3m

Money raised

A Swiss biotech company active in research and development related to breast milk.

8

Funding Rounds

$13.6m

Money raised

Biocrates Life Sciences AG is an Innsbruck-based medical diagnostics company focused on metabolomic research and technology.

2

Funding Rounds

$9.4m

Money raised

Astarte Medical Partners is a startup company headquartered in Yardley, Pennsylvania developing microbial health informatics software that helps optimize nutrition and gut health in preterm infants.

1

Funding Rounds

$2.0m

Money raised

Genetic Analysis AS is an Oslo, Norway-based microbiota research company.

1

Funding Rounds

$40.0m

Money raised

Seed Health is a company founded in 2015.

Key people:

3

Funding Rounds

$302.8m

Money raised

AM-Pharma is a biopharmaceutical company developing recombinant human Alkaline Phosphatase (AP) therapeutics, which have the potential to treat patients with Acute Kidney Injury, Inflammatory Bowel Disease and Hypophosphatasia.

4

Funding Rounds

$14.4m

Money raised

A biotechnology company offering personalized kits for treating acne based on an individuals microbiome.

Location:

Key people:

3

Funding Rounds

$7.3m

Money raised

CosmosID is a microbial genomics platform focused on characterization of microorganisms, pathogens and anti-microbial resistance for infectious disease identification, food safety inspections, pharmaceutical discovery, public health surveillance and microbiome analysis.

5

Funding Rounds

$35.1m

Money raised

GRO Biosciences was founded by Dr. George Church at the Harvard Life Lab.

Key people:

3

Funding Rounds

$2.3m

Money raised

MicroBiome Therapeutics is a New Orleans-based company founded by Dale Pfost.

1

Funding Rounds

$39.0m

Money raised

OrphoMed is a clinical-stage biotechnology company with a proprietary dimer therapeutics platform. The company is focused on developing treatments for patients with gastrointestinal disorders.

7

Funding Rounds

$90.2m

Money raised

EnteroBiotix is a fecal microbiota transplantation founded in 2017 by James McIlroy.

Location:

Key people:

1

Funding Rounds

$15.0m

Money raised

Persephone Biosciences is a company focused on microbiome therapeutics and research.

4

Funding Rounds

$1.3m

Money raised

Carbiotix is a personalized nutrition company that produces consumer gut health products and microbiome therapeutics.

3

Funding Rounds

$2.9m

Money raised

Shoreline Biome is a Farmington, CT-based biotechnology company offering kits for microbiome analysis.

Key people:

3

Funding Rounds

$63.0m

Money raised

Developer of phage technology for targeted control of bacteria.

4

Funding Rounds

$3.6m

Money raised

A company that develops a microbiome discovery platform for animal health.

2

Funding Rounds

$4.0m

Money raised

Ample is a company producing health focused meal replacements founded in 2015 by Bryan Rosenblatt, MARK DIVINE and Connor Young.

Key people:

3

Funding Rounds

$36.3m

Money raised

Rebiotix is a company that is deveoloping microbiota restoration therapy for the treatment of gastrointestinal diseases.

1

Funding Rounds

$2.3m

Money raised

Zbiotics is a company creating genetically engineered probiotics for consumers founded in 2016 by Zachary Abbott.

Key people:

2

Funding Rounds

$2.0m

Money raised

Probiotic product development biopharmaceutical company based in Gothenburg, Sweden.

1

Funding Rounds

$35.0m

Money raised

Whole Biome is a San Francisco-based microbiome diagnostics and therapeutics company.

Location:

Key people:

1

Funding Rounds

$1.0m

Money raised

Precision microbiome engineering company. Epibiome using bacteriophages to combat prevent and treat bacterial infection in humans and agriculture.

1

Funding Rounds

Gallinée produces probiotic skincare products for sensitive skin.

Location:

Key people:

1

Funding Rounds

$8.3m

Money raised

Exeliom is a gut microbiome modifiers founded by Benjamin Hadida, Harry Sokol, Patrick Gervais and Philippe Langella.

Key people:

2

Funding Rounds

$51.0m

Money raised

A San Diego-based company that produces endomicrobial products for animals.

Location:

Key people:

2

Funding Rounds

$3.0m

Money raised

3Bar Biologics is a microbe delivery and manufacturing company that partners with microbe discovery and commercialization companies.

2

Funding Rounds

$10.2m

Money raised

Microba Life Sciences Limited is a company founded in 2018 by Gene Tyson.

Key people:

2

Funding Rounds

$16.8m

Money raised

BCD Bioscience is a Davis, California-based biotechnology company developing ingredients for food, agriculture, and biopharmaceutical applications.

Key people:

2

Funding Rounds

$3.5m

Money raised

ClostraBio, Inc is discovering and developing new therapeutics that modulate the protective ability of the microbiome.

4

Funding Rounds

$2.1m

Money raised

PharmaBiome is a microbiome company.

Location:

Key people:

3

Funding Rounds

$48.0m

Money raised

DayTwo provides personalized nutrition and actionable insights for people to maintain normal blood sugar levels based on their microbiome.

Location:

Key people:

3

Funding Rounds

$64.7m

Money raised

Matrisys Bioscience, Inc. is a dermatology & Skin Care founded in 2015 by Richard Gallo.

2

Funding Rounds

$1.0m

Money raised

Symbiotic Health is a microbiome therapeutics for treating C. diff infections founded in 2013 by Gerard Honig.

Key people:

1

Funding Rounds

$4.4m

Money raised

S-Biomedic brings novel therapeutic solutions to the skin microbiome. S-Biomedic uses a targeted modulation-based technology to modify the skin microbiome. This technology can be applied in both the dermatology and cosmetic industries.

6

Funding Rounds

$392.8m

Money raised

Metagenomi Technologies, LLC is a Gene-Edited Microbial Treatments founded in 2018 by Brian C Thomas.

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