68 Best Startups in Cambridge Massachusetts to Watch in 2025

The Definitive Seedtable Ranking of Startups in Cambridge Massachusetts

We track 71,000+ companies and rank them dynamically using our Seedtable Score – a score that uses quantitative and qualitative data points to signal the momentum behind a company. We then monitor the list manually leveraging our expertise as founders and investors.

There are 600 start-ups with an aggregate funding of $9.4b. The average funding per company in this subset is $138.5m.

Last update to the database: Feb 18, 2025. See changelog.

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9

Funding Rounds

$3.9m

Money raised

Charles River Analytics is a Cambridge, Massachusetts-based R&D solutions provider in 1983.

5

Funding Rounds

$2.1b

Money raised

Commonwealth Fusion Systems is a Cambridge, Massachusetts-based research and development company developing fusion power systems based on ARC tokamak reactors.

5

Funding Rounds

$457.2m

Money raised

EGenesis is a gene editing and genome engineering company developing human-compatible engineered organs to treat diseases

Key people:

13

Funding Rounds

$386.6m

Money raised

A biotechnology company that develops medicines based on live bacterial consortia that can colonize the human intestine.

2

Funding Rounds

$2.3m

Money raised

Sproxil is a Cambridge, Massachusetts-based company.

3

Funding Rounds

$47.0m

Money raised

Robust Intelligence is a Cambridge, Massachussets-based artificial intelligence company co-founded in 2019 by Harvard computer science professor Yaron Singer, Kojin Oshiba, Alexander Rilee, and Eric Balkanski.

Key people:

5

Funding Rounds

$68.7m

Money raised

AOBiome Therapeutics is a therapeutics company, based in Newton, Massachusetts and founded in 2013, that developed strains of Ammonia Oxidizing Bacteria (AOB) to administer live in treatments that address inflammatory conditions.

Key people:

3

Funding Rounds

$4.1m

Money raised

Analytical Space is a satellite communications company making satellites equipped with RD-laser communications technology.

4

Funding Rounds

$41.7m

Money raised

Empatica designs and develops wearable health devices for health monitoring, treatment, and research.

6

Funding Rounds

$11.0m

Money raised

A brain-computer interface company building software and hardware products, neurotechnology tools that interpret human intent, measure emotion and provide telekinetic control of the digital world based on EEG signals.

4

Funding Rounds

$153.5m

Money raised

Sherlock Biosciences is a Cambridge, Massachusetts-based company founded in 2019 by David R. Walt, Rahul Dhanda, Feng Zhang, Jim Collins, Deborah Hung, Jonathan Gootenberg, Omar Abudayyeh, Pardis Sabeti and Todd Golub.

2

Funding Rounds

$164.5m

Money raised

Develops novel cell and gene therapies with pharmacologic operating systems.

6

Funding Rounds

$107.6m

Money raised

Zapata Computing is a company developing quantum software and algorithms for business founded in 2017 by Christopher Savoie, Alán Aspuru-Guzik, Jhonathan Romero Fontalvo, Jonathan Olson, Peter Johnson and Yudong Cao.

12

Funding Rounds

$2.8m

Money raised

HelixNano is a Cambridge, Massachusetts-based biotechnology and artificial intelligence company founded in 2013 by Hannu Rajaniemi and Nikolai Eroshenko.

3

Funding Rounds

$280.0m

Money raised

A therapeutics company founded in 2016 working in drug discovery and development using fungi. LifeMine uses genomics approaches to search for biosynthetic genes in eukaryotic microbes for the discovery of naturally inspired drugs to treat previously untreatable and significant chronic diseases.

Key people:

4

Funding Rounds

$44.0m

Money raised

GNS Healthcare is a data analytics and healthcare company. It was founded in 2000 and is located in Cambridge, Massachusetts.

3

Funding Rounds

$39.9m

Money raised

Rodin Therapeutics was a biotechnology company that developed treatments for Alzheimer's disease. Founded in 2013, it was acquired in 2019 by Alkermes.

Key people:

1

Funding Rounds

$10.5m

Money raised

SmartPharm Therapeutics is a Cambridge, MA-based gene therapy company applying the next generation of non-viral DNA and RNA technologies to treat serious human diseases.

3

Funding Rounds

$109.0m

Money raised

Dyno Therapeutics is a company based in Cambridge, Massachusetts applying artificial intelligence to gene therapy, focused on adeno-associated virus capsid engineering.

Key people:

1

Funding Rounds

$530.0k

Money raised

Wefunder is a company providing a crowd investing platform for startups and offers capital raising services. It participated in the W13 cohort of Y Combinator.

3

Funding Rounds

$124.0m

Money raised

A company that has created a software solution for businesses to monitor their security effectiveness. It was founded in 2011 and is located in Boston, Massachusetts.

3

Funding Rounds

$127.6m

Money raised

An insurance technology company offering a platform for comparing and purchasing automobile insurance.

6

Funding Rounds

$13.4m

Money raised

Cignifi is a company providing credit scores and marketing tools to telecommunications and financial companies.

Key people:

4

Funding Rounds

$96.5m

Money raised

Foundation Medicine is a Cambridge, Massachusetts-based pharmaceutical company developing diagnostic and treatment solutions for cancer care founded in 2010 by Alexis Borisy.

Key people:

1

Funding Rounds

$34.0m

Money raised

A technology manufacturing company making Li-Metal materials, cells, and packs for drones, consumer electronics and automotive applications.

6

Funding Rounds

$227.7m

Money raised

Translate Bio is a clinical-stage mRNA therapeutics company developing medicines to treat diseases caused by protein or gene dysfunction and vaccines against infectious disease pathogens.

6

Funding Rounds

$24.0m

Money raised

Smartvid.io has made a platform for that is interested in providing analysis of industrial media

Key people:

2

Funding Rounds

$386.0m

Money raised

Focused on transforming lives of patients with immune dysfunctions and cancer

2

Funding Rounds

$46.0m

Money raised

Rheostat, located at 300 Technology Square, in Cambridge, Massachusetts is a biotech company developing treatments for neurodegenerative diseases by targeting mitophagy and autophagy pathways.

3

Funding Rounds

$24.1m

Money raised

Cambridge, ma-based text analysis and artificial intelligence company, spun out of the mit media lab and its crowd-sourced open mind common sense (omcs) project

1

Funding Rounds

$13.0m

Money raised

Istari is a Cambridge, Massachusetts-based developer of digital twin technology for various industries, from aerospace to agriculture.

Key people:

6

Funding Rounds

$117.6m

Money raised

Superpedestrian is a Cambridge, Massachusetts-based technology company and manufacturer of lightweight electric vehicles designed to offer eco-friendly transportation for personal use.

5

Funding Rounds

$65.4m

Money raised

An agricultural biotechnology company producing renewable, biomass-based fuels and raw materials

6

Funding Rounds

$40.5m

Money raised

Kebotix is a company using AI and robotics to brainstorm and then test new compounds.

1

Funding Rounds

$6.6m

Money raised

Common Sensing is a company that develops and manufactures hardware and software solutions for people who require the use of injectable medicine

5

Funding Rounds

$136.8m

Money raised

Markforged is a manufacturing company that has invented a 3D printing process to build parts with the strength of Continuous Carbon Fiber.

1

Funding Rounds

$13.0m

Money raised

Ikigai Labs is a software company specializing in making solutions to automate date workflows.

Key people:

3

Funding Rounds

$3.4m

Money raised

FGC Plasma Solutions is an plasma-assisted combustion technology company founded in 2013 by Felipe Gomez del Campo and Drew Weibel

3

Funding Rounds

$50.6m

Money raised

Cambridge, MA-based company developing targeted mRNA therapeutics for cancer and other diseases.

Key people:

2

Funding Rounds

$207.5m

Money raised

Korro Bio is a biotechnology company based in Cambridge, Massachusetts focused on the research and development of RNA editing technology.

4

Funding Rounds

$65.0m

Money raised

Endeca is a Cambridge, Massachusetts-based company founded in 1999.

4

Funding Rounds

$650.0k

Money raised

Wistia is a Cambridge, Massachusetts-based company.

11

Funding Rounds

$35.7m

Money raised

Lightpoint Medical is a solutions developer and provider for the health care industry, specializing in the development of intra-operative, robot-guided systems.

Key people:

1

Funding Rounds

$4.7m

Money raised

Asimov is a startup that programs living cells with genetic circuits.

5

Funding Rounds

$28.0m

Money raised

Biobot Analytics is a company founded in 2017 by Newsha Ghaeli.

Key people:

10

Funding Rounds

$200.5m

Money raised

Emulate is a biotechnology company developing biological products that mimic human biology to study of how diseases, medicines, chemicals, and foods affect human health.

3

Funding Rounds

$210.0m

Money raised

Goldfinch Biopharma is a Cambridge, Massachusetts-based therapeutics company focused on discovering and developing precision therapies for patients with kidney disease.

3

Funding Rounds

$62.0m

Money raised

A biotechnology company in Massachusetts that focuses on developing technology to produce donor-independent human platelets from human induced pluripotent stem cells.

10

Funding Rounds

$786.3m

Money raised

A quantum physics and AI drug research and development company

1

Funding Rounds

$1.5m

Money raised

ThriveHive is a company founded in 2011 by Max Faingezicht, Bryan Pedlar, Nic Mendoza and Adam Blake.

5

Funding Rounds

$162.0m

Money raised

Sense is a Cambridge, Massachusetts-based developer and distributor of energy tracking and automation solutions. Sense specializes in tracking devices and home automation solutions for its customers.

3

Funding Rounds

$7.8m

Money raised

Medical diagnostics company developing diagnostic tests for fever syndromes and infectious diseases

Key people:

1

Funding Rounds

$1.8m

Money raised

Company developing decentralized quantum hardware for portable quantum processing.

8

Funding Rounds

$1.2b

Money raised

Indigo is an agricultural technology company utilizing natural microbiology and digital technologies to improve farmers' profitability, environmental sustainability and consumer health.

5

Funding Rounds

$187.0m

Money raised

Iterative Health is a Cambridge, Massachusetts-based company that provides gastroenterologists with machine learning-powered diagnostic tools to aid in the prevention of colon cancer and improve patient outcomes.

1

Funding Rounds

$763.0k

Money raised

A nuclear reactor design company developing Waste-Annihilating Molten Salt Reactor. The company ceased operations in September 2018.

Key people:

2

Funding Rounds

$47.5m

Money raised

Podimetrics is a diabetic Foot Ulcer Detection founded in 2011 by Jon Bloom, Jeff Engler, Brian Petersen, David Linders and Marnix Hollander.

Key people:

1

Funding Rounds

$10.0m

Money raised

U.S-based web platform connecting insurance providers and payers.

Industries:

7

Funding Rounds

$13.7m

Money raised

Sigma Ratings is a New York, United States-based company founded in 2016 by Gabrielle Haddad.

3

Funding Rounds

$190.2m

Money raised

Cancer drugs that target specific types of poly ADP-ribose polymerase

5

Funding Rounds

$20.4m

Money raised

Klarity provides an automated contract review solution for enterprises.

3

Funding Rounds

$3.8m

Money raised

Sentenai is a Boston-based AI company.

3

Funding Rounds

$138.0m

Money raised

Pandion Therapeutics is a Cambridge, Massachusetts-based company developing modular proteins, antibodies and bispecifics for autoimmune and inflammatory diseases.

2

Funding Rounds

$71.0m

Money raised

nference is a Cambridge-based knowledge synthesis software platform that extracts insights from biomedical literature.

5

Funding Rounds

$80.2m

Money raised

Humantics is a software company that was founded in 2015.

2

Funding Rounds

$63.5m

Money raised

Osmo AI is the developer of a platform intended to give computers the sense of smell.

Key people:

1

Funding Rounds

An education platform for senior care training CareAcademy offers an online training empowering senior care professionals to deliver the highest caliber of services.

4

Funding Rounds

$20.0m

Money raised

Oasys Water was a company that developed water treatment and filtration products.

Key people:

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