48 Best Autoimmune Disease Startups to Watch in 2025

The Definitive Seedtable Ranking of Autoimmune Disease Startups

We track 71,000+ companies and rank them dynamically using our Seedtable Score – a score that uses quantitative and qualitative data points to signal the momentum behind a company. We then monitor the list manually leveraging our expertise as founders and investors.

There are 48 start-ups with an aggregate funding of $2.7b. The average funding per company in this subset is $57.2m.

Last update to the database: Feb 18, 2025. See changelog.

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5

Funding Rounds

$76.5m

Money raised

A clinical-stage biopharmaceutical company engaging in drug discovery and drug development for treating autoimmune disease and cancer.

3

Funding Rounds

$14.3m

Money raised

Aria Pharmaceuticals is a first-in-class pharmaceutical discovery and development founded in 2014 by Andrew M. Radin.

5

Funding Rounds

$28.9m

Money raised

Antidote.me closes the gap between clinical trials and patients

2

Funding Rounds

$67.5m

Money raised

A company developing immunotherapy treatments for cancers, infectious and autoimmune diseases

3

Funding Rounds

$37.4m

Money raised

A diagnostics company developing products for diagnosis, prognosis and monitoring of patients with autoimmune rheumatic diseases

5

Funding Rounds

$152.0m

Money raised

Synthetic biology company that created novel DNA base pairs and uses them to incorporate novel amino acids into proteins for potential therapeutics in areas of cancer and autoimmune disorders.

1

Funding Rounds

$2.0m

Money raised

A life science instrumentation company developing ellipsometry analysis systems for microplates and slide disposables

2

Funding Rounds

$27.0m

Money raised

Vital Therapies is a biotechnology company developing a cell-based therapy to treat acute liver failure.

2

Funding Rounds

$110.0m

Money raised

Kyverna is a cell therapy company engineering a new class of curative living medicines for inflammatory and autoimmune diseases.

4

Funding Rounds

$72.3m

Money raised

Abcuro develops immunotherapies to treat autoimmunity and cancer.

8

Funding Rounds

$84.5m

Money raised

Mogrify is developing tailored cellular conversions that power future cell therapies.

1

Funding Rounds

Biotherapeutics company focused on medicines for chronic inflammation, metabolic disease and autoimmune disease

3

Funding Rounds

$138.0m

Money raised

Pandion Therapeutics is a Cambridge, Massachusetts-based company developing modular proteins, antibodies and bispecifics for autoimmune and inflammatory diseases.

2

Funding Rounds

$70.0m

Money raised

Delinia is a biotechnology company that is developing novel therapeutics for treating autoimmune diseases.

Key people:

12

Funding Rounds

$108.1m

Money raised

Calcimedica is a clinical-stage biotechnology company targeting calcium release-activated calcium (CRAC) channels for the treatment of inflammatory and autoimmune disorders and organ transplant rejection.

1

Funding Rounds

$44.0m

Money raised

Annexon Biosciences is a South San Francisco, California-based biotechnology company working on discovering and developing therapeutics for neurodegenerative and autoimmune disorders.

3

Funding Rounds

$210.0m

Money raised

Biotechnology company developing medicines that target allosteric regulatory sites on proteins

Key people:

5

Funding Rounds

$4.1m

Money raised

DxTerity Diagnostics is a genomics company developing genomic tests for disease diagnosis and monitoring. Los Angeles-based company.

8

Funding Rounds

$235.2m

Money raised

Crescendo Bioscience is a company that is developing diagnostic tools for autoimmune and inflammatory disease.

Key people:

4

Funding Rounds

$3.3m

Money raised

Girihlet provides an immune map database. Its platform aims to accelerate immune diseases discovery, monitoring and therapeutic approaches.

Key people:

3

Funding Rounds

$13.5m

Money raised

A company developing treatments for cancer and autoimmune diseases

6

Funding Rounds

$474.7m

Money raised

Cell therapy firm specializing in developing treatments using advanced cellular technology.

7

Funding Rounds

$123.8m

Money raised

A company focused on developing immunotherapy treatments for autoimmune disease and cancer

1

Funding Rounds

$40.6m

Money raised

Therapies designed to achieve long-term disease remission with less frequent doses.

2

Funding Rounds

$32.0m

Money raised

Biond Biologics is an Israel-based immunotherapy company developing treatments for cancer and autoimmune diseases.

5

Funding Rounds

$147.5m

Money raised

A biotechnology company focused on the development of therapeutics for the treatmjent of autoimmune and inflammatory diseases

2

Funding Rounds

$62.5m

Money raised

A biopharmaceutical company developing oral small molecule therapies for the treatment of cancer and autoimmune diseases

8

Funding Rounds

$33.4m

Money raised

Innovate Biopharmaceuticals was the name of a clinical stage biotechnology company focused on developing therapeutics for autoimmune and inflammatory diseases. In 2019 Innovate merged with RDD Pharma and renamed the company 9 Meters Biopharma.

1

Funding Rounds

$10.0m

Money raised

A biopharmaceutical company developing small molecule, antiviral drug treatments for the treatment of autoimmune diseases, neuropathic pain, liver diseases and cancer

3

Funding Rounds

$27.0k

Money raised

KPI Therapeutics is a company that focuses on developing potentially game changing autoimmune therapies.

Key people:

2

Funding Rounds

$59.5m

Money raised

Ignyta is a company that combines medicine and biotechnology for the treatment of cancer and autoimmune diseases.

Location:

1

Funding Rounds

$4.0m

Money raised

A biotechnology company focused on developing covalent drugs for the treatment of cancer and other autoimmune diseases

1

Funding Rounds

$20.0m

Money raised

A company developing immune-based biologics for the treatment of cancer, autoimmunity, transplantation and infectious diseases

3

Funding Rounds

$60.0m

Money raised

A biotechnology company developing therapies and personalized diagnostics for celiac disease

2

Funding Rounds

$5.1m

Money raised

A company developing compounds for the treatment of autoimmune diseases

1

Funding Rounds

$2.0m

Money raised

A company developing targeted therapeutics for inflammation, autoimmune, oncology, neurodegenerative and central nervous system conditions

2

Funding Rounds

$5.5m

Money raised

A biotechnology company developing peptides and antibodies for inflammation and autoimmunity

2

Funding Rounds

$7.8m

Money raised

A biopharmaceutical company that develops biologic products to treat lupus and other autoimmune diseases

2

Funding Rounds

$16.8m

Money raised

A drug discovery and development company focused on immunotherapeutic agents to treat cancer, viral infections and autoimmune diseases

1

Funding Rounds

$3.0m

Money raised

A biopharmaceutical company developing small molecule therapeutics for respiratory, inflammatory and autoimmune diseases

2

Funding Rounds

$12.0m

Money raised

A biotechnology company developing treat ments for sickle cell disease, cancer, asthma autoimmune and inflammatory diseases

1

Funding Rounds

$1.5m

Money raised

A company developing therapies modulatng T-cell activities to treat autoimmune diseases, diabetes and cancer

1

Funding Rounds

$300.0k

Money raised

A biotechnology company developing immune tolerance therapies products for the treatment of autoimmune diseases in the lung

1

Funding Rounds

$30.0m

Money raised

A biopharmaceutical company that develops drugs for autoimmune and inflammatory diseases

2

Funding Rounds

$26.5m

Money raised

A biopharmaceutical company developing treatments and prevention for inflammatory, autoimmune disease and cancer

1

Funding Rounds

$250.0k

Money raised

A company drugs for the treatment of infectious diseases, cancer and autoimmune disorders

1

Funding Rounds

$20.5m

Money raised

A company developing X-nitro compounds for micro treatments for cancer, inflamation, cardiovascular and autoimmune diseases

1

Funding Rounds

$50.0m

Money raised

Syntimmune is a Boston-based company.

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