69 Best Startups in Seattle to Watch in 2025

Mythical Games is a Los Angeles-based video game development company developing games for playable non-fungible tokens to identify game characters that players can own and offers players a secondary market.

Arzeda is a biotechnology and software company designing custom microorganisms for industrial applications through computational enzyme design, protein optimization, and metabolic engineering.

Pembient uses advances in biotechnology to fabricate horn and other wildlife products to combat the threat to endangered species.

Boundless is a Seattle-based company offering immigrants tools, information, and personalized support to facilitate their immigration journey.

Esper provides a DevOps platform for Android-based devices. The platform features cloud management tools for device deployment, app development, and monitoring.

Shelf Engine is a Seattle-based software company and developer of an automated prediction ordering platform for food retailers, intended to reduce food waste.

Insilico Medicine is a drug discovery, artificial intelligence company that looks to treat cancer and age related diseases

Temporal offers an open-source runtime system platform that enables a variety of applications and services.

SirionLabs provides a contract lifecycle management (CLM) platform for enterprises.

Rec Room is a Seattle-based augmented and virtual reality software company.

LevelTen Energy provides a clean energy procurement platform for midsize businesses and enterprises.

Seeq is a company that offers an application that processes data analytics.

Moz is a company developing and providing inbound marketing analytics software.

Spice AI is a Seattle-based start-up company building a developer-first platform to create artificial intelligence/machine learning-driven applications that harness time series data.

Porch is a home services platform that helps home and property owners maintain their homes, by connecting them with professionals.

Stoke Space is a company manufacturing space vehicle components and performing scientific and technological services associated with the space industry.

Impinj wirelessly connects billions of everyday things to applications, delivering real-time information to businesses, and enabling the Internet of Things.

ExtraHop Networks is a Seattle, Washington-based cybersecurity technology company.

Uplevel is a software company that provides a machine learning-based engineering effectiveness platform designed to assess employee performance and generate actionable insights.

Symbl is an API platform for businesses looking to deploy conversational intelligence.

Outreach is a sales engagement platform that uses artificial intelligence (AI) for predictive analytics as it relates to sales.

Avalanche Energy Designs is an American start-up company designing, testing, and building micro-fusion reactors.

Seattle Food Tech is a food manufacturing technology and production company producing plant-based meats. They make plant-based food and plant-based chicken nuggets.

Hyperproof is a cloud-based compliance operations software.

Pulse Labs is a Seattle-based development company offering tools and services to help companies develop voice, mobile, and automotive experiences.

Textio is a writing-enhancement service powered by big data.

SingleStore is a San Francisco-based database software and analytics company offering a platform to help companies operationalize their data.

Highspot provides a sales enablement platform that increases the success of sales teams across many industries.

Membrion is a Seattle-based clean technology company and developer of flexible ceramic ion exchange membranes capable of being used in wastewater cleaning and in energy storage solutions.

One More Game is a Seattle-based startup that specializes in the development of online video games.

Trupanion is a Seattle-based provider of pet insurance for cats and dogs in the United States, Canada, Europe, Australia, and Puerto Rico.

Taqtile is a Seattle-based software company building augmented and mixed reality solutions for industrial processes, complex task learning, and data visualization.

Worksphere is a Seattle-based workplace management platform to help businesses create safe and flexible workplaces.

A-Alpha Bio is a startup that has built a platform technology and aims to speed up the development of new drugs.

CLIPr is a Kirkland, Washington-based video analysis and management company using AI and machine learning for searching and identifying key moments.

Scope 5 is a Seattle-based software company offering sustainability reporting and collating services to help companies achieve greater sustainability in their operations and offer companies reporting on sustainability and related efforts where necessary.

Swiftly is a developer of a digital platform to help brands and retailers build loyalty and reach more shoppers.

Wyze is a Seattle-based company developing smart home products and wireless cameras.

Glowforge offers 3D laser printers based on laser cutting and engraving technology that cut, engrave, and shape designs from various materials.

Developing a AAA Multiplayer Shooter powered by blockchain, creative modding, and true digital ownership.

Rainway is a Seattle-based developer of real-time, low-latency tools for streaming, intended for developers and organizations to develop interactive streaming.

Rival IQ is a Seattle-based social media analytics and competitive benchmarking company.

YourBase is a Seattle-based software company developing software testing tools for development teams.

Tasso is a Seattle-based manufacturer and supplier of blood-based diagnostic tools.

Skilljar is a Seattle-based cloud-based learning management system to help business increase customer and partner training programs.

InsightStudios is a startup studio founded in 2021 by Dave Linhardt.

SoundCommerce is a Seattle-based operations data platform developer offering businesses and brands data, business intelligence, and decision support tools.

Tanium is a company providing security and systems management solution for businesses.

Shape Security is a Mountain View, California-based company. It was acquired by F5 Networks in 2019.

Legalpad is an information technology and services company that assists start-ups in getting work visas for their employees.

Evernym is a software company that develops an open source sovereign identity block chain.

Vita Inclinata Technologies is a company developing safety systems for helicopters and other aerospace platforms.

Amperity is a Seattle, Washington-based company that offers a customer data platform (CDP) for enterprises.

Moderne is a company developing code automation for software development.

Lumen Bioscience is a biotechnology founded on April 1, 2017, operating out of Seattle, Washington, making an industrial molecular production platform using the blue-green algae Spirulina capable of producing valuable proteins and other molecules.

Indemnis UAV Recovery Systems is an Anchorage, Alaska-based company developing safety solutions to the commercial UAV community.

Headset is a tech company providing an IT solution for the cannabis industry.

NextStep is an information technology company providing training and job placement for workers through a mobile application platform.

Relativity Space is a company that develops the process of building and flying rockets.

Bloom API is a healthcare company focused on communication practices.

Edge Delta is a Seattle-based developer of an observability automation platform capable of making sense of complex data sets and reducing index volumes.

Steth IO is a digital health startup company producing a smartphone integrated stethoscope to visualize and hear heart and lung sounds as well as artificial intelligence software for improved characterization.

Oisin develops anti-aging treatments that target and remove senescent cells, a type of damaged cell that is unable to divide, accumulates during aging and contribute to age-related diseases.

Groopit is a Seattle-based developer of a collaboration platform intended to give users data analysis through mobile phones and multi-group implementation.

OctoML provides an automated deployment machine learning software platform, designed to optimize and speed up the performance of AI solutions at the network edge.

Zap Energy is developing compact fusion power that doesn't require magnets or lasers.

Insight Data Science is a Palo Alto-based education startup providing post-doctoral training programs in the big data industry.

Stacklok is a Seattle-based software developing offering tools to help developers and open-source software communities keep their software secure and choose safe dependencies.

Apptentive is a customer feedback solution that measures shifts in sentiment from customer experience to win back consumers and activate fans. The Apptentive solution helps enterprise brands including Starbucks, Dunkin Donuts, Jetblue, and eBay. Apptentive captures actionable emotions and feedback from the 90 percent of consumer voices typically missed, and quickly turns that feedback into action.