45 Best Gene Therapy Startups to Watch in 2025

The Definitive Seedtable Ranking of Gene Therapy Startups

We track 71,000+ companies and rank them dynamically using our Seedtable Score – a score that uses quantitative and qualitative data points to signal the momentum behind a company. We then monitor the list manually leveraging our expertise as founders and investors.

There are 45 start-ups with an aggregate funding of $4.1b. The average funding per company in this subset is $90.8m.

Last update to the database: Feb 18, 2025. See changelog.

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SmartPharm Therapeutics logo

SmartPharm Therapeutics

SmartPharm Therapeutics is a Cambridge, MA-based gene therapy company applying the next generation of non-viral DNA and RNA technologies to treat serious human diseases.

1

Funding Rounds

$10.5m

Money raised

Integrated DNA Technologies logo

Integrated DNA Technologies

Integrated DNA Technologies is a Coralville, Iowa-based company founded in 1987.

1

Funding Rounds

Dyno Therapeutics logo

Dyno Therapeutics

Dyno Therapeutics is a company based in Cambridge, Massachusetts applying artificial intelligence to gene therapy, focused on adeno-associated virus capsid engineering.

3

Funding Rounds

$109.0m

Money raised

Juventus Therapeutics logo

Juventus Therapeutics

Juventas Therapeutics is a biotechnology company founded in 2007 that is headquartered in Cleveland, Ohio developing a pipeline of regenerative therapies to treat life-threatening diseases.

4

Funding Rounds

$46.7m

Money raised

OncoSenX logo

OncoSenX

OncoSenX is a spinout company of Oisin Biotechnologies, formed to develop programmable suicide gene therapy to kill cancerous cells.

5

Funding Rounds

$19.7m

Money raised

GentiBio logo

GentiBio

GentiBio, Inc. is a biotherapeutics company developing engineered regulatory T cells (Tregs) therapies for immunology.

2

Funding Rounds

$177.0m

Money raised

Immusoft logo

Immusoft

Immusoft is a biotechnology company developing a platform for the insertion of therapeutic genes into immune cells for the treatment of a variety of genetic diseases.

11

Funding Rounds

$37.9m

Money raised

Locate Bio logo

Locate Bio

Locate Bio is a biotechnology developing cell and gene therapies for treating damaged tissues and organs.

9

Funding Rounds

$59.1m

Money raised

Ablitech, Inc. logo

Ablitech, Inc.

A biotechnology company founded in 2006 and based in Baltimore, MD, that develops polymers to deliver DNA and RNA therapeutics.

1

Funding Rounds

$2.0m

Money raised

Argonaut Therapeutics logo

Argonaut Therapeutics

Precision therapeutics company developing epigenetic therapies that target arginine methylation in cancer.

2

Funding Rounds

$2.6m

Money raised

Spark Therapeutics logo

Spark Therapeutics

Spark Therapeutics is a Philadelphia-based therapeutics and biotechnology company founded in 2013.

2

Funding Rounds

$122.8m

Money raised

Diadem Biotherapeutics logo

Diadem Biotherapeutics

Biotherapeutics company focused on medicines for chronic inflammation, metabolic disease and autoimmune disease

1

Funding Rounds

Encoded Therapeutics, Inc. logo

Encoded Therapeutics, Inc.

Encoded Therapeutics is a developer of genomics-driven precision medicine targeting and treating genetic diseases and disorders.

4

Funding Rounds

$343.1m

Money raised

Cytonus Therapeutics logo

Cytonus Therapeutics

Cytonus Therapeutics is a biotechnology company developing adaptive cellular therapies for treating immune-oncology and inflammatory diseases.

4

Funding Rounds

$2.6m

Money raised

Targazyme logo

Targazyme

Targazyme is a biotechnology company focused on improving survival and quality of life for cancer patients using stem cell transplantation, immunotherapy, regenerative medicine, and gene therapy.

1

Funding Rounds

$2.5m

Money raised

Forge Biologics logo

Forge Biologics

Forge is a gene therapy development engine, focused on enabling access to life changing gene therapies and helping bring them from idea into reality.

2

Funding Rounds

$160.0m

Money raised

Brainvectis logo

Brainvectis

Brainvectis is a biotechnology company developing treatments for neurodegenerative diseases through restoring cholesterol metabolism in the brain.

1

Funding Rounds

$1.2m

Money raised

Vineti logo

Vineti

Vineti is a cloud-based cell-therapy management system founded in 2016 by Razmik Abnous.

6

Funding Rounds

$152.3m

Money raised

Calimmune logo

Calimmune

Calimmune is a biotechnology company developing gene and stem cell therapies for treating rare and serious diseases.

1

Funding Rounds

$15.9m

Money raised

AavantiBio logo

AavantiBio

AAVANTIBio is a biotechnology company developing gene therapies.

2

Funding Rounds

$213.9m

Money raised

iVexSol logo

iVexSol

iVexSol is a newly formed viral vector manufacturing company

2

Funding Rounds

$15.0m

Money raised

StrideBio logo

StrideBio

StrideBio is a Durham, North Carolina-based company.

3

Funding Rounds

$97.2m

Money raised

Apic Bio logo

Apic Bio

Apic Bio is a gene Therapy founded in 2017 by John Reilly.

5

Funding Rounds

$70.7m

Money raised

Kriya Therapeutics logo

Kriya Therapeutics

Kriya Therapeutics is a gene Therapy founded in 2019 by Shankar Ramaswamy, J. Fraser Wright and Roger Jeffs.

3

Funding Rounds

$455.6m

Money raised

ElevateBio logo

ElevateBio

ElevateBio is a company founded by Vikas Sinha, David Hallal and Melissa Carpenter.

2

Funding Rounds

$695.0m

Money raised

Limelight Bio logo

Limelight Bio

Limelight Bio is a biopharmaceutical company researching and developing novel gene therapy technologies.

3

Funding Rounds

$139.0m

Money raised

Xalud Therapeutics logo

Xalud Therapeutics

Xalud Therapeutics is a neuropathic pain therapies.

2

Funding Rounds

$55.2m

Money raised

Renova Therapeutics logo

Renova Therapeutics

Renova Therapeutics is a company that envisions a future where it can permanently treat chronic diseases

2

Funding Rounds

$7.5m

Money raised

Kolon TissueGene logo

Kolon TissueGene

Kolon TissueGene is a biotechnology company developing cell and gene therapies for treating osteoarthritis.

2

Funding Rounds

$59.7m

Money raised

Unchained Labs logo

Unchained Labs

Unchained Labs is a tools for biologics research & development founded in 2015 by Tim Harkness.

1

Funding Rounds

$13.0m

Money raised

CureGenetics logo

CureGenetics

CureGenetics is a biotechnology company using CRISPR to develop cellular therapies, gene therapies, and molecular diagnostic tools.

2

Funding Rounds

$34.0m

Money raised

Integra Therapeutics logo

Integra Therapeutics

Integra Therapeutics is a biotech company engineering the next generation of gene writing tools to cure genetic diseases.

3

Funding Rounds

$16.1m

Money raised

Hemera Biosciences logo

Hemera Biosciences

Hemera Biosciences is a treatment for dry macular degeneration company founded in 2010 by Jay S. Duker, Elias Reichel and Adam Rogers.

1

Funding Rounds

$1.3m

Money raised

InnoSkel logo

InnoSkel

InnoSkel is a therapies for Rare Skeletal Diseases founded in 2020 by Elvire Gouze.

2

Funding Rounds

$44.0m

Money raised

Ring Therapeutics logo

Ring Therapeutics

Ring Therapeutics is a multi-product platform company.

2

Funding Rounds

$167.0m

Money raised

XyloCor Therapeutics logo

XyloCor Therapeutics

XyloCor Therapeutics is focused on improving the lives of people with cardiovascular disease through our commitment to advancing the science of gene therapy.

2

Funding Rounds

$58.9m

Money raised

Shoreline Biosciences, Inc. logo

Shoreline Biosciences, Inc.

Shoreline Biosciences, Inc. is a Cell-Based Immunotherapies founded in 2020 by Kleanthis G. Xanthopoulos.

4

Funding Rounds

$229.0m

Money raised

Lysogene logo

Lysogene

Lysogene is a company by Karen Aiach.

1

Funding Rounds

$16.5m

Money raised

Nuntius Therapeutics logo

Nuntius Therapeutics

Nuntius Therapeutics is a cell-specific DNA, RNA and CRISPR therapies founded in 2021 by Albert Kwok.

1

Funding Rounds

$130.0k

Money raised

Genespire logo

Genespire

Gene therapies developer for pediatric patients.

1

Funding Rounds

$52.0m

Money raised

Notch Therapeutics logo

Notch Therapeutics

Notch Therapeutics is a gene-modified T cell therapy.

1

Funding Rounds

$85.0m

Money raised

Myosana Therapeutics logo

Myosana Therapeutics

Myosana Therapeutics is a non-viral Gene Therapy founded in 2018.

1

Funding Rounds

$1.0m

Money raised

Gracell logo

Gracell

Gracell is a China-based company founded in 2017.

1

Funding Rounds

$85.0m

Money raised

Ikarovec logo

Ikarovec

Ikarovec is an ocular Gene Therapy founded in 2018.

1

Funding Rounds

$3.3m

Money raised

Gyroscope Therapeutics Ltd logo

Gyroscope Therapeutics Ltd

Gyroscope Therapeutics Ltd is a United Kingdom-based company founded in 2016.

2

Funding Rounds

$205.7m

Money raised