69 Best Rna Based And Rna Targeted Therapeutics Startups to Watch in 2025

The Definitive Seedtable Ranking of Rna Based And Rna Targeted Therapeutics Startups

We track 71,000+ companies and rank them dynamically using our Seedtable Score – a score that uses quantitative and qualitative data points to signal the momentum behind a company. We then monitor the list manually leveraging our expertise as founders and investors.

There are 77 start-ups with an aggregate funding of $6.6b. The average funding per company in this subset is $96.2m.

Last update to the database: Feb 18, 2025. See changelog.

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6

Funding Rounds

$4.6m

Money raised

Nanomedicine company developing vaccines and therapies with cell-specific targeting.

2

Funding Rounds

$192.0m

Money raised

Scipher Medicine is a precision immunology company that aims to match patients with their most effective therapy. Their proprietary platform, Spectra, combines AI and a network map of protein interactions in the human body to make predictions.

1

Funding Rounds

$11.2m

Money raised

Talus Bioscience is a Seattle-based company founded by Alex Federation.

6

Funding Rounds

$227.7m

Money raised

Translate Bio is a clinical-stage mRNA therapeutics company developing medicines to treat diseases caused by protein or gene dysfunction and vaccines against infectious disease pathogens.

2

Funding Rounds

$71.5m

Money raised

Now known as Sierra Oncology, is a clinical stage drug development company in Vancouver that focuses on cancer and hematology treatments.

2

Funding Rounds

$207.5m

Money raised

Korro Bio is a biotechnology company based in Cambridge, Massachusetts focused on the research and development of RNA editing technology.

4

Funding Rounds

$226.0m

Money raised

Arrakis is developing RNA-targeted small molecule (rSM) therapies to millions of patients.

1

Funding Rounds

$27.0m

Money raised

Quark Pharmaceuticals is a RNAi-based, late stage clinical company founded in 2002 by Daniel Zurr.

1

Funding Rounds

$14.2m

Money raised

Stemirna Therapeutics is an mRNA therapeutics and nanoparticle formulation company in China focused on treatments for cancer, infectious diseases and rare diseases.

5

Funding Rounds

$4.1m

Money raised

DxTerity Diagnostics is a genomics company developing genomic tests for disease diagnosis and monitoring. Los Angeles-based company.

1

Funding Rounds

$59.0m

Money raised

A therapeutics company developing siRNA and ASO therapeutics that target repeat expansion disorders such as Huntington’s disease, myotonic dystrophy and spinocerebellar ataxias

Key people:

5

Funding Rounds

$6.6m

Money raised

OyaGen is an HIV Drug Discovery, Editing Enzymes founded in 2003 by Harold Smith.

Key people:

3

Funding Rounds

$3.0m

Money raised

Seqll is a company providing quantitative RNA and specialty DNA sequencing services.

2

Funding Rounds

$36.0m

Money raised

A research and development company for miRNA-directed treatments for cancer and other diseases

4

Funding Rounds

$210.6m

Money raised

Locanabio is a San Diego, California-based biotechnology company developing RNA-targeting gene therapies.

Location:

Key people:

6

Funding Rounds

$49.6m

Money raised

Spring Bank Pharmaceuticals, Inc. is a company founded in 2002

4

Funding Rounds

$101.6m

Money raised

Small molecule inhibitors of RNA-modifying enzymes for the treatment of cancer

6

Funding Rounds

$799.0m

Money raised

Small Molecules Acting on Stem Cells. Biosplice Therapeutics is in the medical research and development for tissue-level regeneration.

1

Funding Rounds

$45.5m

Money raised

Silence Therapeutics is a London-based company founded in 1999.

Location:

Key people:

4

Funding Rounds

$52.8m

Money raised

Small molecule drugs that target functional 3D RNA structures to treat human diseases.

2

Funding Rounds

$29.0m

Money raised

Eclipse Bioinnovations is a San Diego-based company that develops RNA medicines.

2

Funding Rounds

$17.4m

Money raised

A company that provides cell and tissue based diagnostic tests for personalized medicine development

3

Funding Rounds

$103.1m

Money raised

Strand Therapeutics is a gene Therapy founded by Darrell Irvine, Jacob Becraft, Ron Weiss and Tasuku Kitada.

Key people:

2

Funding Rounds

$135.3m

Money raised

Expansion Therapeutics is a RNA Targeted Small Molecules founded in 2016.

4

Funding Rounds

$126.7m

Money raised

Geneoscopy, Inc. is a St. Louis-based developer of medical diagnostics systems including non-invasive cancer diagnostics from biomarkers.

Location:

Key people:

2

Funding Rounds

$2.0m

Money raised

Alithea Genomics backgrounds in bioengineering, molecular biology, genomics and lab operations reflect their complementary expertise.

Location:

Key people:

3

Funding Rounds

$17.6m

Money raised

A biotechnology company developing intracellular genetic protein therapy to treat chronic heart failure

Key people:

4

Funding Rounds

$179.0m

Money raised

Vico Therapeutics is a medicine for rare neurological diseases founded in 2019.

2

Funding Rounds

$7.5m

Money raised

Renova Therapeutics is a company that envisions a future where it can permanently treat chronic diseases

3

Funding Rounds

$14.8m

Money raised

RNAimmune is a biotechnology startup in the field of messenger RNA (mRNA) technology with more than 20 years’ expertise in handling and optimizing this versatile molecule for medical purposes.

2

Funding Rounds

$321.0m

Money raised

Orna Therapeutics is a biotechnology company dedicated to designing and delivering a new class of fully engineered circular RNA (oRNA) therapeutics.

5

Funding Rounds

$37.6m

Money raised

InteRNA Technologies is a biotech company.

2

Funding Rounds

$48.0m

Money raised

Skyhawk Therapeutics is a RNA-correcting Small Molecules founded in 2016 by Bill Haney.

Key people:

1

Funding Rounds

$60.0m

Money raised

Mirvie is a biotech company that creates precise, actionable, and non-invasive tests for maternal-fetal health.Mirvie is a biotech company that creates precise, actionable, and non-invasive tests for maternal-fetal health.

4

Funding Rounds

$1.4b

Money raised

Abogen Biosciences is a China-based company.

Location:

Key people:

2

Funding Rounds

$151.0m

Money raised

Small molecule therapies designed to reprogram RNA processing

Key people:

1

Funding Rounds

$65.0m

Money raised

Twentyeight-Seven is a biomedical startup with a passion for cutting-edge life saving technology.

3

Funding Rounds

$33.6m

Money raised

Amyl Therapeutics unique technology offers a curative solution for all forms of amyloid mediated diseases

Location:

Key people:

1

Funding Rounds

$8.6m

Money raised

Ra Pharmaceuticals is a Cambridge, Massachusetts-based company.

3

Funding Rounds

$99.0m

Money raised

An immunotherapy company developing approaches to enable the body's immune system to fight against diseases

2

Funding Rounds

$147.5m

Money raised

Shape Therapeutics is a RNA-editing gene therapy.

3

Funding Rounds

$60.0m

Money raised

A biotechnology company developing therapies and personalized diagnostics for celiac disease

1

Funding Rounds

$3.0m

Money raised

HDT Bio Corp. is a RNA delivery technology, Immune Activators (Adjuvants.

1

Funding Rounds

$23.0m

Money raised

MiNA Therapeutics is a small activating RNA founded in 2008.

2

Funding Rounds

$187.1m

Money raised

Leyden Labs is a mucosal protection platform founded in 2020.

2

Funding Rounds

$8.6m

Money raised

A company developing biomedical polymers technology for therapeutic applications

3

Funding Rounds

$114.0m

Money raised

A company developing antithrombotic drug systems to treat acute and sub-acute cardiovascular and other indications

2

Funding Rounds

$33.3m

Money raised

A company developing immunomodulators to treat acute inflammatory conditions

1

Funding Rounds

$2.0m

Money raised

GenVec is a biopharmaceutical company developing therapeutics and vaccines founded in 1992.

1

Funding Rounds

$19.0m

Money raised

PhaseRx is a company developing macromolecular therapeutics to treat diseases.

2

Funding Rounds

$13.7m

Money raised

Promosome is a company developing technologies to regulate protein synthesis founded in 2003.

1

Funding Rounds

$440.0m

Money raised

Laronde is a plasmid RNA Therapeutics.

1

Funding Rounds

$23.6m

Money raised

RXi Pharmaceuticals is a company developing ribonucleic acid interference-based therapeutics founded in 2011.

1

Funding Rounds

$11.0m

Money raised

Resalis Therapeutics is developing first-in-class anti-miR compounds to address high unmet medical needs in liver diseases, metabolic disorders, and cancer using a multi-pathway approach.

Location:

1

Funding Rounds

$11.3m

Money raised

InDex Pharmaceuticals is a Stockholm-based company developing immunotherapy products.

2

Funding Rounds

$46.9m

Money raised

Cebix is a biopharmaceutical company developing treatments for diabetic complications founded in 2008.

Location:

1

Funding Rounds

$75.0m

Money raised

ADARx is developing a RNA targeting platform focused on genetic, cardiometabolic and central nervous system diseases

1

Funding Rounds

Abcombi Biosciences is a company founded in 2015 by Andrew Hill, Ph.D. .

1

Funding Rounds

$20.0m

Money raised

iTolerance is a Miami, Florida-based biotechnology company specializing in regenerative medicine without immunosuppression.

1

Funding Rounds

$7.0m

Money raised

A technology company with a focus on precision oncology solutions.

1

Funding Rounds

$11.0m

Money raised

Wobble Genomics specializes in maximizing RNA and DNA sequencing efficiency for the discovery and detection of nucleic acid biomarkers.

1

Funding Rounds

$8.0m

Money raised

Empowering drug discovery with Proteomics and ML to unlock complex biological insights and enable better therapeutics.

1

Funding Rounds

$6.0m

Money raised

Groove Biopharma. is a biotechnology company.

1

Funding Rounds

$15.0m

Money raised

Codetta Biosciences is a Morrisville, North Carolina-based company.

1

Funding Rounds

$28.0m

Money raised

Quris is an AI Drug Discovery.

1

Funding Rounds

$21.0m

Money raised

Vernal Biosciences is a mRNA Production founded in 2021 by Christian Cobaugh.

Key people:

3

Funding Rounds

$80.1m

Money raised

ReadCoor is a Cambridge, Massachusetts-based company founded in 2016 by Evan Daugharthy.

1

Funding Rounds

$1.0m

Money raised

Sistemic is a MiRNA Services.

1

Funding Rounds

$1.6m

Money raised

RNA inhibitor-based therapeutics developer for treating intractable cancers and genetic conditions.

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