68 Best Startups in Illinois to Watch in 2025

The Definitive Seedtable Ranking of Startups in Illinois

We track 71,000+ companies and rank them dynamically using our Seedtable Score – a score that uses quantitative and qualitative data points to signal the momentum behind a company. We then monitor the list manually leveraging our expertise as founders and investors.

There are 105 start-ups with an aggregate funding of $3.8b. The average funding per company in this subset is $55.7m.

Last update to the database: Feb 18, 2025. See changelog.

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4

Funding Rounds

$167.0m

Money raised

League is a digital health benefits provider.

4

Funding Rounds

$73.0m

Money raised

An insurance technology company offering a platform for insurance claims.

3

Funding Rounds

$50.0m

Money raised

Anodot is a software development company that has created a business monitoring platform.

Key people:

1

Funding Rounds

$4.5m

Money raised

Octopai is a centralized, cross-platform metadata management automation solution.

2

Funding Rounds

$24.7m

Money raised

Bright Security (previously NeuraLegion) is a San Rafael, California-based company offering developer-centric dynamic application security testing (DAST) software.

Key people:

1

Funding Rounds

$2.5m

Money raised

BiomeSense, Inc. is a biotechnology company developing microbiome technologies for the collection, storage, and analysis of gut microbiome profiles.

Key people:

2

Funding Rounds

$75.0m

Money raised

Duda is a responsive website builder for digital marketing agencies, hosting companies, and online directories.

5

Funding Rounds

$257.0m

Money raised

Coralogix is a company founded in 2014 by Lior Tal, Ariel Assaraf, Lior Redlus and Guy Kroupp.

Key people:

1

Funding Rounds

$12.0m

Money raised

MIGAL Research Institute is a company that provides applied research that is specialized in the fields of biotechnology, environmental and agricultural sciences

Industries:

5

Funding Rounds

$109.0m

Money raised

Upstream Security is an artificial intelligence company founded by Yoav Levy that develops automotive cloud security software.

Key people:

5

Funding Rounds

$47.9m

Money raised

An artificial intelligence company that protects faces from being identified by facial recognition technologies

Key people:

1

Funding Rounds

$15.0m

Money raised

Pontis is an Illinois-based advertising company founded in 2004 by Michael Kerbis.

Industries:

Location:

Key people:

8

Funding Rounds

$186.8m

Money raised

Sight is a blood diagnostic company based in Tel Aviv, Israel.

Key people:

2

Funding Rounds

$26.5m

Money raised

Anzu.io is an in-game advertising platform.

4

Funding Rounds

$697.0m

Money raised

DriveNets is an Israel-based networking software startup

Key people:

1

Funding Rounds

$5.3m

Money raised

Runtime Verification is a startup company focused on runtime verification approaches for the improvement of software systems.

3

Funding Rounds

$182.0m

Money raised

Trigo is a technology company that builds AI-powered infrastructure for retail stores.

Location:

Key people:

7

Funding Rounds

$257.6m

Money raised

G2 is a company founded by Michael Wheeler.

Key people:

2

Funding Rounds

$3.0m

Money raised

Pangea is a company founded in 2012.

3

Funding Rounds

$23.6m

Money raised

Nostromo is a company founded in 2017.

4

Funding Rounds

$8.2m

Money raised

Rippleshot is a Chicago-based data protection company offering fraud and risk management software founded in 2012 by Canh Tran, Yueyu Fu and Randal Cox.

Location:

Key people:

2

Funding Rounds

$58.0m

Money raised

Nucleix is a San Diego-based developer and manufacturer of molecular cancer diagnostic tests.

6

Funding Rounds

$100.5m

Money raised

Aurora Labs is a company founded in 2016 by Zohar Fox.

Location:

Key people:

4

Funding Rounds

$84.5m

Money raised

DealHub.io is a revenue amplification platform that delivers consistent sales engagements at every step of the sales process.

Key people:

5

Funding Rounds

$100.0m

Money raised

Autotalks is a company founded in 2008 by Hagai Zyss.

Location:

Key people:

5

Funding Rounds

$46.5m

Money raised

Karamba Security is an automotive Security & IoT Protection founded in 2016 by Ami Dotan.

3

Funding Rounds

$47.5m

Money raised

Source Defense provides websites with the first ever prevention technology for attacks of third-party origin.

Location:

Key people:

2

Funding Rounds

$45.0m

Money raised

Shopic is an Illinois-based retail company founded by Raz Golan, Dan Bendler and Eran Kravitz.

Industries:

Location:

Key people:

1

Funding Rounds

$10.0m

Money raised

DocAuthority is a Raanana, Isreal-based technology company developing AI-powered data management tools.

2

Funding Rounds

$22.0m

Money raised

Upshot is a company founded in 1994 by Joseph Turian.

3

Funding Rounds

$30.1m

Money raised

ThinkCERCA is a company founded in 2012 by Eileen Murphy.

Location:

Key people:

2

Funding Rounds

$8.0m

Money raised

Market Beyond is a company founded in 2015 by Yuval Yifrach.

Key people:

5

Funding Rounds

$81.2m

Money raised

ZenCity is a company founded by Eyal Feder-Levy.

Location:

Key people:

2

Funding Rounds

$20.8m

Money raised

Oktopost is a company founded in 2013 by Daniel Kushner.

Location:

Key people:

3

Funding Rounds

$111.0m

Money raised

Orasis Pharmaceuticals develops a corrective eye drop to treat presbyopia as an alternative to reading glasses.

1

Funding Rounds

$95.0m

Money raised

Infinidat is a company developing, manufacturing and providing data storage and protection devices.

Key people:

5

Funding Rounds

$1.0m

Money raised

DOV-E is a telecommunications company that is focused on mobile payments.

1

Funding Rounds

$31.3m

Money raised

NutriSense is a metabolic health platform that combines real-time monitoring with personalized dietitian coaching.

Key people:

4

Funding Rounds

$2.2m

Money raised

Verifyoo's BehavioMetric Protection Suite is an end to end solution covering login, account recovery and fraud prevention.

Key people:

2

Funding Rounds

$3.5m

Money raised

ZooZ is a company founded in 2010 by Ronen Morecki, Oren Levy and Eyal Kotler.

1

Funding Rounds

$21.0m

Money raised

GuardKnox is developing a hardware cyber security solution for automotive manufacturers.

4

Funding Rounds

$31.2m

Money raised

A software company offering an artificial intelligence platform for behavioural analytics.

Key people:

3

Funding Rounds

$26.5m

Money raised

YCD Multimedia is a company founded in 1999.

1

Funding Rounds

Scout is a company founded in 2013.

4

Funding Rounds

$104.0m

Money raised

MD Clone is a vendor of MDClone ADAMS, a self-service data analytics environment enabling healthcare collaboration, research, and innovation.

4

Funding Rounds

$11.2m

Money raised

GetAlert is an Herzliya-based artificial intelligence company.

Location:

Key people:

1

Funding Rounds

$1.0m

Money raised

Jivana Biotechnology develops preclinical stage drugs for application in cancer treatment.

2

Funding Rounds

$38.0m

Money raised

Rezilion is a stealth mode cyber-security start-up developing a cutting edge technology that makes cloud environments self-protecting and resilient to cyber-attacks.

Key people:

1

Funding Rounds

$4.8m

Money raised

A company developing and manufacturing biosurgical and immunotherapy products

18

Funding Rounds

$10.0m

Money raised

Click Deal Buy! Inc. is an e-commerce company founded in 2017.

2

Funding Rounds

$3.5m

Money raised

ClostraBio, Inc is discovering and developing new therapeutics that modulate the protective ability of the microbiome.

4

Funding Rounds

$211.3m

Money raised

StreamElements is a company founded in 2017 by Doron Nir.

Key people:

2

Funding Rounds

$11.0m

Money raised

Allegro.AI is a company founded in 2016 by Nir Bar-Lev, Gil Westrich and Moses Guttmann.

1

Funding Rounds

$21.0m

Money raised

Envoy Global is a company founded in 1998.

1

Funding Rounds

$500.0k

Money raised

TOTAL MULTIMEDIA INCORPORATED is a technology company specializing in digital video compression and playback software.

1

Funding Rounds

Digital Trowel is a data mining company.

Industries:

Location:

2

Funding Rounds

Airscort is a commercial Drone Docking and Recharging Station founded in 2014 by Yitzhak Tal.

3

Funding Rounds

$25.9m

Money raised

Eyesight Technologies is a company founded in 2006 by Itay Katz.

Key people:

4

Funding Rounds

$29.7m

Money raised

Jolt is a Tel Aviv-based education technology company offering courses for consumers and professionals in micro-campuses across the world.

1

Funding Rounds

$200.0k

Money raised

BeeFree Agro is an agro-tech company that is addressing the needs of free-grazing livestock ranchers by controlling the location and movement of livestock in open pastures.

Key people:

4

Funding Rounds

$34.0m

Money raised

XJet is a company in Israel.

Location:

Key people:

1

Funding Rounds

$10.0m

Money raised

Whatify is a crystal ball that enables people to see the future of their business and act on it.

1

Funding Rounds

$14.0m

Money raised

The first and only PoC-as-a-Service platform, prooV accelerates smart, secure technology adoption, critical for enterprises' survival and growth

1

Funding Rounds

$15.0m

Money raised

CYREBRO, previously known as CyberHat, is a proactive Cyber Defense solutions company specializing in cyber defense and intelligence, with a wide range of experience from all areas of the cyber domain.

Key people:

1

Funding Rounds

$32.3m

Money raised

Tomedes is a professional translation services founded in 2007 by Ofer Tirosh.

2

Funding Rounds

$786.5k

Money raised

CENS is a company that develops technology for improving the energy and power of super-capacitors and lithium ion batteries.

2

Funding Rounds

$2.0m

Money raised

Protego Labs, Inc. is a company that develops security services for providing security to serverless applications.

1

Funding Rounds

Massivit 3D Printing Technologies Ltd. is a company in Israel.

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