30 Best Startups in Framingham Massachusetts to Watch in 2025

The Definitive Seedtable Ranking of Startups in Framingham Massachusetts

We track 71,000+ companies and rank them dynamically using our Seedtable Score – a score that uses quantitative and qualitative data points to signal the momentum behind a company. We then monitor the list manually leveraging our expertise as founders and investors.

There are 30 start-ups with an aggregate funding of $919.4m. The average funding per company in this subset is $30.6m.

Last update to the database: Feb 18, 2025. See changelog.

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8

Funding Rounds

$92.7m

Money raised

Develops medicines for patients suffering from Alzheimer's disease and other neurological disorders.

1

Funding Rounds

$35.0m

Money raised

Applause is a venture funded startup founded in 2007 by Doron Reuveni.

8

Funding Rounds

$14.8m

Money raised

Punchbowl is a Framingham, Massachusetts-based developer of web-based software platform for event planning, event management, digital and custom invitations, and greeting cards.

6

Funding Rounds

$105.6m

Money raised

Variantyx is a Framingham, Massachusetts-based medical diagnostics company developing DNA genetic testing methods founded in 2014 by Haim Neerman, Noam Shomron and Tomer Jackman.

2

Funding Rounds

$12.3m

Money raised

Dust Identity is a logistic and object tracking company founded by Ophir Gaathon.

3

Funding Rounds

$45.0m

Money raised

CyberX was a Waltham, Massachusetts-based cybersecurity company. The company was acquired by Microsoft in June 2020.

3

Funding Rounds

$3.1m

Money raised

Nimbit is a company that

3

Funding Rounds

$18.3m

Money raised

Raven360 provides a sales readiness platform that delivers up-to-date and consistent sales content, training and coaching.

1

Funding Rounds

$80.0m

Money raised

Alira Health is a Paris-based company founded in 1999 by Gabriele Brambilla.

2

Funding Rounds

$8.5m

Money raised

Disruptor Beam is a Boston-based company founded in 2011 by Jon Radoff.

1

Funding Rounds

$10.0m

Money raised

Boston Heart Diagnostics is a Framingham, Massachusetts-based healthcare company offering diagnostics and health management tools for cardiovascular disease.

4

Funding Rounds

$22.6m

Money raised

Vivox is a Natick, Massachusetts-based company founded in 2013 by Jeff Pulver, Rob Seaver and Jim Toga.

3

Funding Rounds

$15.2m

Money raised

Prelert is an elastic company that provides machine learning anomaly detection and behavioral analytics for IT security.

4

Funding Rounds

$126.6m

Money raised

1

Funding Rounds

$500.0k

Money raised

WoundForce is a Framingham, Massachusetts-based therapeutics company focused on solutions to unmet clinical needs in the area of chronic wounds.

2

Funding Rounds

$17.0m

Money raised

Cloud-native data protection platform for Kubernetes, OpenStack and Virtualization.

5

Funding Rounds

$46.0m

Money raised

RaveMobileSafety.com is a Framingham, Massachusetts-based company founded in 2004.

1

Funding Rounds

$3.2m

Money raised

Transplant Genomics is a Mansfield, Massachusetts-based medical diagnostics company offering noninvasive serial monitoring for organ transplants and rejection founded in 2013 by Daniel Salomon.

1

Funding Rounds

$120.0m

Money raised

Re:Build Manufacturing is a family of industrial businesses. Explore some of our core competencies: Product Innovation, Component Production, Systems Production, and Industrial Automation.

1

Funding Rounds

With 25+ years of experience and over 36,000 locations, DTiQ enhances profitability for quick-service restaurants, specialty retail, and convenience stores. We drive performance through revenue growth, efficiency, employee engagement, and loss prevention.

1

Funding Rounds

$8.0m

Money raised

Inhaled glycopolymer-based therapeutics for the treatment of pulmonary disease

1

Funding Rounds

$6.2m

Money raised

Sofregen Medical Inc. is a company founded in 2014.

7

Funding Rounds

$84.4m

Money raised

ALZHEON, INC. is a Framingham, Massachusetts-based company.

7

Funding Rounds

$26.9m

Money raised

Beamable, Inc. is a Framingham, Massachusetts-based company.

4

Funding Rounds

$8.5m

Money raised

BLUESPEC INC is a Framingham, Massachusetts-based company.

1

Funding Rounds

$250.0k

Money raised

wiseHer, Inc. is a Framingham, Massachusetts-based company founded in 2018.

1

Funding Rounds

$350.0k

Money raised

Partrunner Deliveries, Inc. is a Framingham, Massachusetts-based company founded in 2017.

1

Funding Rounds

$1.0m

Money raised

ListEngage Holdings, LLC is a Framingham, Massachusetts-based company founded in 2018.

1

Funding Rounds

$4.1m

Money raised

TMI/RR Winthrop Road Brookline Investor LLC is a Framingham, Massachusetts-based company founded in 2019.

1

Funding Rounds

$3.5m

Money raised

Commonwealth Farm 1761, Inc. is a Framingham, Massachusetts-based company founded in 2018.

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