69 Best Startups in Southampton Massachusetts to Watch in 2025

The Definitive Seedtable Ranking of Startups in Southampton Massachusetts

We track 71,000+ companies and rank them dynamically using our Seedtable Score – a score that uses quantitative and qualitative data points to signal the momentum behind a company. We then monitor the list manually leveraging our expertise as founders and investors.

There are 2,676 start-ups with an aggregate funding of $15.7b. The average funding per company in this subset is $226.8m.

Last update to the database: Feb 18, 2025. See changelog.

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6

Funding Rounds

$95.0m

Money raised

ClimaCell is a Boston-based weather intelligence platform for automated weather predictions.

5

Funding Rounds

$236.7m

Money raised

A genetic medicine company that build data platforms using synthetic biology, artificial intelligence and genetic medicine for the development of medical therapies.

9

Funding Rounds

$3.9m

Money raised

Charles River Analytics is a Cambridge, Massachusetts-based R&D solutions provider in 1983.

7

Funding Rounds

$267.5m

Money raised

Immuta is a Boston-based provider of a cloud-native data governance platform for organizations to automate data access control, security, and privacy compliance.

10

Funding Rounds

$1.6b

Money raised

Snyk is a technology company offering a software development security platform using open-source code.

8

Funding Rounds

$741.4m

Money raised

Desktop Metal is a Burlington, Massachusetts-based metal 3D printing company founded in 2015 by Ric Fulop, Jonah Myerberg, and Ely Sachs.

5

Funding Rounds

$45.8m

Money raised

Boundless is a Seattle-based company offering immigrants tools, information, and personalized support to facilitate their immigration journey.

9

Funding Rounds

$1.1b

Money raised

Circle is a peer-to-peer payments technology company that is headquartered in Boston, Massachusetts and was founded in 2013 by Jeremy Allaire and Sean Neville.

10

Funding Rounds

$1.0b

Money raised

DataRobot sells a machine learning platform that helps users build and deploy accurate predictive models. The Boston-based company was founded in 2012 by Jeremy Achin.

4

Funding Rounds

$1.5m

Money raised

Aura Vision is an AI computer vision company for generating insights into shop floors. Aura Vision uses existing security cameras in stores to provide customer demographics and behavior data.

7

Funding Rounds

$254.1m

Money raised

Owkin is a medical treatment and therapeutics company founded by Thomas Clozel. They develop artificial intelligence and machine learning tools to augment and develop medical and biological research.

5

Funding Rounds

$390.0m

Money raised

PathAI is a Boston-based artificial intelligence company developing therapeutics and healthcare products.

6

Funding Rounds

$144.4m

Money raised

Ayla Networks is a technology company developing a platform as a service (PaaS) for managing internet of things (IoT) devices.

7

Funding Rounds

$63.3m

Money raised

Catalog is a Boston, Massachusetts-based company developing a platform for DNA-based digital data storage.

9

Funding Rounds

$364.0m

Money raised

Altiostar Networks is a company that provides 4G and 5G open vRAN software in a B2B model.

5

Funding Rounds

$2.1b

Money raised

Commonwealth Fusion Systems is a Cambridge, Massachusetts-based research and development company developing fusion power systems based on ARC tokamak reactors.

3

Funding Rounds

$10.0m

Money raised

The RepTrak Company, formerly the Reputation Institute, is a Boston-based data-driven reputation analysis company founded in 1997 by Cees van Riel, Dr. Charles Fombrun, Kasper Ulf Nielsen and Nicolas Georges Trad.

5

Funding Rounds

$457.2m

Money raised

EGenesis is a gene editing and genome engineering company developing human-compatible engineered organs to treat diseases

Key people:

5

Funding Rounds

$43.9m

Money raised

Via Separations is a Watertown, Massachusetts-based company founded in 2016 by Shreya Dave.

6

Funding Rounds

$37.7m

Money raised

MachineMetrics is a developer of industrial IoT analytics and a machine monitoring platform.

1

Funding Rounds

$300.0m

Money raised

BGI is a life science and genomics organization following a development model of research, production and application.

5

Funding Rounds

$33.8m

Money raised

Armored Things is a Boston-based company founded in 2017 by Julie Johnson, Chris Lord and Charles Curran.

6

Funding Rounds

$44.8m

Money raised

VoltDB is a Bedford, Massachusetts-based developer of an in-memory SQL and relational database offering transaction processing in a horizontal scale-out platform.

7

Funding Rounds

$8.4m

Money raised

Pison is a human performance company that optimizes cognitive and physiological capability using gesture control.

6

Funding Rounds

$678.5m

Money raised

Klaviyo is a marketing automation software company which has a email software platform with SMS for ecommerce companies.

3

Funding Rounds

$13.5m

Money raised

Binah.ai is a company that provides artificial intelligence-powered, video-based health and wellness monitoring.

13

Funding Rounds

$386.6m

Money raised

A biotechnology company that develops medicines based on live bacterial consortia that can colonize the human intestine.

10

Funding Rounds

$568.0m

Money raised

An insurance technology company offering artificially intelligent software for insurance fraud detection and claims handling.

Location:

5

Funding Rounds

$111.8m

Money raised

Orig3n is a biotechnology company developing personalized regenerative medicine treatments based on patient genetic profiles.

3

Funding Rounds

$42.5m

Money raised

A healthcare company using artificial intelligence to help track and predict the onset of human diseases.

6

Funding Rounds

$119.0m

Money raised

Zoe is a Boston and London-based company which builds software for tracking individuals' nutrition response patterns, as well as a mobile application for tracking COVID-19 symptoms.

7

Funding Rounds

$428.8m

Money raised

Aiven is a company that offers a managed open-source and multi-cloud data platform.

2

Funding Rounds

$2.3m

Money raised

Sproxil is a Cambridge, Massachusetts-based company.

3

Funding Rounds

$47.0m

Money raised

Robust Intelligence is a Cambridge, Massachussets-based artificial intelligence company co-founded in 2019 by Harvard computer science professor Yaron Singer, Kojin Oshiba, Alexander Rilee, and Eric Balkanski.

4

Funding Rounds

$13.0m

Money raised

Help Scout is a company developing a software platform for customer service.

5

Funding Rounds

$68.7m

Money raised

AOBiome Therapeutics is a therapeutics company, based in Newton, Massachusetts and founded in 2013, that developed strains of Ammonia Oxidizing Bacteria (AOB) to administer live in treatments that address inflammatory conditions.

3

Funding Rounds

$4.1m

Money raised

Analytical Space is a satellite communications company making satellites equipped with RD-laser communications technology.

4

Funding Rounds

$6.5m

Money raised

A digital fertility clinic offering semen analysis, sperm improvement, and sperm cryostorage services. Founded at Harvard in 2018, the company has raised $20M from investors like Y Combinator, Bain Capital Ventures, FirstMark Capital, and celebrities like Justin Bieber.

4

Funding Rounds

$41.7m

Money raised

Empatica designs and develops wearable health devices for health monitoring, treatment, and research.

2

Funding Rounds

$8.1m

Money raised

Wanderu is a developer of a travel meta-search engine used to book inter-city buses and trains.

2

Funding Rounds

$50.0m

Money raised

Neighborly drives investment in world-positive infrastructure projects like broadband, solar microgrids, and libraries.

2

Funding Rounds

$192.0m

Money raised

Scipher Medicine is a precision immunology company that aims to match patients with their most effective therapy. Their proprietary platform, Spectra, combines AI and a network map of protein interactions in the human body to make predictions.

3

Funding Rounds

$107.0m

Money raised

Drift is a software company offering a conversational marketing platform founded in 2015 by David Cancel.

8

Funding Rounds

$144.9m

Money raised

Logz.io is an AI-powered log analysis platform that offers the open-source ELK Stack as an enterprise-grade service.

2

Funding Rounds

$83.0m

Money raised

Mimecast is a London-based cybersecurity and email management platform company founded by Neil Murray and Peter Bauer.

14

Funding Rounds

$87.2m

Money raised

A medical company in Massachusetts focusing on lowering the cost of vaccine distribution.

8

Funding Rounds

$192.5m

Money raised

Botkeeper combines artificial intelligence and machine learning technology with accountants to deliver a bookkeeping & pre-accounting solution to accounting firms and their clients.

6

Funding Rounds

$349.2m

Money raised

A healthcare company helping patients management their health and their involvement in the healthcare system.

Industries:

Location:

Key people:

5

Funding Rounds

$57.1m

Money raised

Metabolon is a company developing metabolomics analytical methods and software for biomarker discovery

2

Funding Rounds

$4.5m

Money raised

Cellink AB is a biotechnology research company based in Gothenburg.

1

Funding Rounds

Clear Ballot is a Boston-based company founded in 2009.

Location:

9

Funding Rounds

$262.0m

Money raised

A biotechnology company using genetic editing technologies to develop therapies for the treatment of cancer and genetic diseases.

7

Funding Rounds

$90.0m

Money raised

Benu Networks is a Burlington, Massachusetts-based company that provides a virtual service platform designed to deliver internet protocol (IP) services.

6

Funding Rounds

$11.0m

Money raised

A brain-computer interface company building software and hardware products, neurotechnology tools that interpret human intent, measure emotion and provide telekinetic control of the digital world based on EEG signals.

8

Funding Rounds

$92.7m

Money raised

Develops medicines for patients suffering from Alzheimer's disease and other neurological disorders.

4

Funding Rounds

$153.5m

Money raised

Sherlock Biosciences is a Cambridge, Massachusetts-based company founded in 2019 by David R. Walt, Rahul Dhanda, Feng Zhang, Jim Collins, Deborah Hung, Jonathan Gootenberg, Omar Abudayyeh, Pardis Sabeti and Todd Golub.

2

Funding Rounds

$164.5m

Money raised

Develops novel cell and gene therapies with pharmacologic operating systems.

6

Funding Rounds

$107.6m

Money raised

Zapata Computing is a company developing quantum software and algorithms for business founded in 2017 by Christopher Savoie, Alán Aspuru-Guzik, Jhonathan Romero Fontalvo, Jonathan Olson, Peter Johnson and Yudong Cao.

2

Funding Rounds

$6.0m

Money raised

Privy is a company founded in 2011 by Ben Jabbawy.

5

Funding Rounds

$175.6m

Money raised

Preply is a fast-growing ed-tech company, backed by Europe's most prominent investors.

12

Funding Rounds

$2.8m

Money raised

HelixNano is a Cambridge, Massachusetts-based biotechnology and artificial intelligence company founded in 2013 by Hannu Rajaniemi and Nikolai Eroshenko.

6

Funding Rounds

$80.4m

Money raised

Rasa is a company that offers a conversational AI platform for customized conversations at scale.

6

Funding Rounds

$97.6m

Money raised

VMRay provides threat detection and analysis to enterprises.

3

Funding Rounds

$280.0m

Money raised

A therapeutics company founded in 2016 working in drug discovery and development using fungi. LifeMine uses genomics approaches to search for biosynthetic genes in eukaryotic microbes for the discovery of naturally inspired drugs to treat previously untreatable and significant chronic diseases.

3

Funding Rounds

$7.6m

Money raised

Embr Labs is a technology company that focuses on wellness that harnesses the power of cutting-edge technology to improve thermal comfort.

4

Funding Rounds

$44.0m

Money raised

GNS Healthcare is a data analytics and healthcare company. It was founded in 2000 and is located in Cambridge, Massachusetts.

7

Funding Rounds

$72.5m

Money raised

Accion Systems is a company that provides in-space propulsion systems for satellites

10

Funding Rounds

$133.6m

Money raised

A technology that designs carbon nanotube electronics, which can be used as memory devices. It was founded in 2001 and is located in Woburn, Massachusetts.

7

Funding Rounds

$668.2m

Money raised

Cybereason is a Boston-based cybersecurity company.

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