69 Best Startups in San Mateo California to Watch in 2025

The Definitive Seedtable Ranking of Startups in San Mateo California

We track 71,000+ companies and rank them dynamically using our Seedtable Score – a score that uses quantitative and qualitative data points to signal the momentum behind a company. We then monitor the list manually leveraging our expertise as founders and investors.

There are 335 start-ups with an aggregate funding of $10.5b. The average funding per company in this subset is $152.1m.

Last update to the database: Feb 18, 2025. See changelog.

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9

Funding Rounds

$307.0m

Money raised

Forge, formerly Equidate, is a company that offers a marketplace for private stock liquidation.

Key people:

8

Funding Rounds

$390.0m

Money raised

Exabeam is a San Mateo, California-based data security analytics company offering cybersecurity and early cyber attack detection software.

9

Funding Rounds

$369.3m

Money raised

SnapLogic is a San Mateo, California-based software development company offering an enterprise cloud integration platform.

Key people:

7

Funding Rounds

$218.1m

Money raised

SendBird is a developer of a messaging API for mobile applications and websites.

Key people:

2

Funding Rounds

$12.2m

Money raised

Haptik is a company developing conversational AI for customer experience.

Key people:

2

Funding Rounds

$14.2m

Money raised

A San Mateo, CA-based wearables company that uses haptic feedback technology to increase a user's awareness of their surroundings using sound.

Key people:

4

Funding Rounds

$138.9m

Money raised

Verkada is a software company offering a cloud-based internet of things (IoT) platform for security camera systems.

Key people:

2

Funding Rounds

$161.5k

Money raised

Orian Span was a commercial space agency that aimed to become the first company to place luxury hotel in space.

Key people:

9

Funding Rounds

$5.1m

Money raised

Stottler Henke is a San Mateo, California-based company founded in 1988.

6

Funding Rounds

$714.0m

Money raised

An insurance technology offering a platform for companies to manage health insurance policies for their employees.

1

Funding Rounds

$50.0m

Money raised

Vyond is a video animation software company.

3

Funding Rounds

$138.0m

Money raised

Pinecone is a company developing a fully managed, cloud-native vector database, simplifying adding vector search to production applications and providing long-term memory for AI applications.

8

Funding Rounds

$192.1m

Money raised

IntelePeer is a software company and customer communications platform.

Key people:

6

Funding Rounds

$62.5m

Money raised

Avegant is California-based company developing display techologies for augmented reality experiences.

4

Funding Rounds

$105.0m

Money raised

Belong is a San Mateo, California-based real estate technology company developing a software platform for property management for the home renting process.

Key people:

10

Funding Rounds

$2.5b

Money raised

Tipalti automates the way companies pay suppliers, partners, publishers and employees with cloud-based solutions which addresses all phases of the payables workflow.

Key people:

7

Funding Rounds

$235.0m

Money raised

Incorta is a software company making analytics software platform founded in 2013 by Osama Elkady.

Key people:

7

Funding Rounds

$268.8m

Money raised

TruePill is a US-based company providing pharmacy product deliveries.

2

Funding Rounds

$116.0m

Money raised

Skylo Technologies, Inc. is a Palo Alto, California-based telecommunications and satellite IoT company developing solutions for wireless networks for machine data.

Key people:

9

Funding Rounds

$28.5m

Money raised

A company with an explainable artificial intelligence platform that can analyze data for government, financial services, and healthcare. It was founded in 2014 and is located in San Mateo, California.

3

Funding Rounds

$5.3m

Money raised

An insurance technology company offering a platform for healthcare organizations to access health insurance data to improve their ability to bring new products and services to market.

3

Funding Rounds

$21.5m

Money raised

Rockset is a San Mateo, California-based developer of a real-time analytics platform built to operate in the cloud and offer users quick queries on real-time data and user-facing analytics.

Key people:

8

Funding Rounds

$327.0m

Money raised

FalconX is a blockchain, cryptocurrency, and fintech-focused brokerage and digital asset trading platform.

Key people:

14

Funding Rounds

$851.4m

Money raised

Skydio uses artificial intelligence to create flying drones that are used by consumer, enterprise, and government customers.

Key people:

2

Funding Rounds

$12.2m

Money raised

Xignite is a cloud-based financial data distribution and market data mangement technology company.

Key people:

1

Funding Rounds

$3.5m

Money raised

Biotechnology company using Artificial Intelligence to discover drugs by translating life sciences big data into therapies

7

Funding Rounds

$610.0m

Money raised

Newfront Insurance is a company that provides technologies that are designed to simplify brokerage processes

Key people:

2

Funding Rounds

$18.0m

Money raised

Symmetry Systems is a provider of data store and object-level security (DSOS) solutions that give organizations visibility into, and unified access control of, their most valuable data assets.

Key people:

8

Funding Rounds

$71.8m

Money raised

Alpaca is a company that supplies a trading platform designed for investors and traders. It was founded in 2015 and is located in San Mateo, California.

6

Funding Rounds

$650.0k

Money raised

QuSecure is a Menlo Park, California-based cybersecurity company that is developing quantum security applications, it was founded in 2019 by Skip Sanzeri, Rebecca Krauthamer, Dave Krauthamer, and Kosta Vilk.

4

Funding Rounds

$64.5m

Money raised

Alfresco is a software company founded in 2005 by John Newton, John Newton and John Powell.

1

Funding Rounds

$4.0m

Money raised

Caring.com is an elderly care company.

9

Funding Rounds

$309.0m

Money raised

A consumer company providing customers with the latest in Asian beauty products, culture and trends.

4

Funding Rounds

$72.7m

Money raised

Theta Lake is a video classification startup dedicated to addressing the challenges organizations face in managing increasing video content and communication.

2

Funding Rounds

$16.0m

Money raised

Alluxio is an open source data orchestration layer that brings data close to compute for big data and AI/ML workloads in the cloud.

Key people:

3

Funding Rounds

$82.0m

Money raised

OneSignal is a multi-platform service for pushing notifications and emails.

Key people:

2

Funding Rounds

$30.0m

Money raised

A real-time health data network in California that focuses on improving people's health and quality of life through data liquidity.

4

Funding Rounds

$2.5m

Money raised

Luminate Health is a San Mateo, California-based company founded in 2012 by Sidd Sinha, Shally Madan and Jessica Hsu.

Key people:

8

Funding Rounds

$276.2m

Money raised

Feedzai is a San Mateo, California-based Information Technology & Services company.

Key people:

1

Funding Rounds

$12.0m

Money raised

Digital Chocolate is a San Mateo, California-based company founded in 2003 by Trip Hawkins.

4

Funding Rounds

$31.8m

Money raised

Owler is a business information and insights platform providing company data and real-times news and updates.

2

Funding Rounds

$71.5m

Money raised

Now known as Sierra Oncology, is a clinical stage drug development company in Vancouver that focuses on cancer and hematology treatments.

8

Funding Rounds

$84.8m

Money raised

Wonder Workshop is an education and robotics startup based in San Mateo, California

8

Funding Rounds

$71.7m

Money raised

Lattice Engines is a San Mateo, California-based analytics company offering AI-powered solutions for enterprises.

1

Funding Rounds

$42.2m

Money raised

Soteria Biotherapeutics is a biotechnology company developing cancer immunotherapies.

4

Funding Rounds

$9.8m

Money raised

HealthCrowd is a San Mateo, California-based company founded in 2010 by Neng-Bing Doh, Bern Shen and Clive Wu.

Key people:

1

Funding Rounds

$15.0m

Money raised

Developer and publisher of fulfilling free-to-play online games. Available across browsers, mobile and social networks. Learn more.

Key people:

3

Funding Rounds

$11.8m

Money raised

A technology company with a sensory interface platform which allows users to speak and hear clearly in extreme noise, wind, under mask and under water. It was founded in 2010 and is located in San Mateo, California.

Key people:

2

Funding Rounds

$35.0m

Money raised

Epocrates is a company founded in 1998 by Richard Fiedotin.

8

Funding Rounds

$113.7m

Money raised

Agari is a Foster City, California-based cybersecurity company using artificial intelligence for the provision of email threat prevention and protection.

5

Funding Rounds

$43.1m

Money raised

Reflektion is a company that offers a personalization platform to deliver individualized shopping experiences across all online touch points.

4

Funding Rounds

$41.5m

Money raised

SugarSync is a San Mateo, California-based company founded in 2008.

5

Funding Rounds

$132.7m

Money raised

Notable Health is an artificial intelligence-powered health start up in California that focuses on automating and digitizing physician-patient interactions.

Key people:

4

Funding Rounds

$9.7m

Money raised

EARTH AI is a San Mateo, California-based mineral deposit exploration company founded by Roman Teslyuk in 2016.

5

Funding Rounds

$37.8m

Money raised

End-to-end training data platform that automates data preparation at scale and makes building datasets quick, systematic, and repeatable.

Key people:

6

Funding Rounds

$39.3m

Money raised

Tachyus is a company founded in 2014 by Dakin Sloss, Paul Orland, Joel Moxley, Francisco Leport and Pallav Sarma.

Industries:

Key people:

1

Funding Rounds

$8.0m

Money raised

Ople is an AI-based company that provides solutions for improving data science process.

6

Funding Rounds

$146.3m

Money raised

Totango is a customer success company that develops a platform to track customer engagement and referrals.

4

Funding Rounds

$68.0m

Money raised

Meru Health provides a digital program to treat depression and burnout. It participated in the S18 cohort of Y Combinator.

1

Funding Rounds

$20.0m

Money raised

WageWorks is a San Mateo, California-based company in the consulting industry founded in 2000 by Daniel Corbett.

3

Funding Rounds

$117.0m

Money raised

Conga is an enterprise cloud computing and data company offering a platform for simplifying and automating data, documents, contracts, and reporting.

6

Funding Rounds

$404.0m

Money raised

Apttus was a San Mateo, California-based software company developing solutions to automate a company's approach to quotes, contracts, and documents, and was founded in 2006 by Kirk Krappe, Neehar Giri and Kent Perkocha.

3

Funding Rounds

$66.0m

Money raised

DotData is a Cupertino, California-based big data company that delivers end-to-end data science automation for enterprises.

1

Funding Rounds

$8.5m

Money raised

Arda Therapeutics is a San Mateo, California-based biotechnology company developing cell-based therapeutics for disease.

6

Funding Rounds

$38.2m

Money raised

Jivox is a San Mateo, California-based advertising company offering a cloud-based, data-driven digital marketing platform.

1

Funding Rounds

$12.0m

Money raised

Artificial intelligence company providing AI-powered chatbots and semantic search to boost self-service and e-commerce conversions.

Key people:

5

Funding Rounds

$4.8m

Money raised

WhoKnows developed an omni-channel lead generation platform, powered by AI, for use in startup companies.

2

Funding Rounds

$52.0m

Money raised

Narvar is a San Mateo, California-based company founded in 2012.

3

Funding Rounds

$99.3m

Money raised

BigHat Biosciences is a company with a mission to enhance human health by making it easier to design advanced antibody therapeutics.

Key people:

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