55 Best Startups in Charlottesville Virginia to Watch in 2025

The Definitive Seedtable Ranking of Startups in Charlottesville Virginia

We track 71,000+ companies and rank them dynamically using our Seedtable Score – a score that uses quantitative and qualitative data points to signal the momentum behind a company. We then monitor the list manually leveraging our expertise as founders and investors.

There are 55 start-ups with an aggregate funding of $931.2m. The average funding per company in this subset is $16.9m.

Last update to the database: Feb 18, 2025. See changelog.

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9

Funding Rounds

$165.3m

Money raised

Everactive provides a hardware toolkit and managed network purpose-built for self-powered devices.

1

Funding Rounds

$10.0m

Money raised

Contraline is a company developing contraceptive for men founded in 2015 by Kevin Eisenfrats.

1

Funding Rounds

$40.0m

Money raised

Fermata Energy is bringing together electric vehicles and the electricity grid

2

Funding Rounds

$13.6m

Money raised

MSi is a specialized provider of next generation cyber defense solutions protecting control systems and critical physical assets in energy, transportation and defense.

1

Funding Rounds

$17.4m

Money raised

ChartIQ is a Charlottesville, Virginia-based company founded in 2012 by Dan Schleifer, Megan Read and Terry Thorsen.

5

Funding Rounds

$24.4m

Money raised

AgroSpheres develops novel technologies that aim to set a new standard for bio-based delivery of active ingredients.

Key people:

3

Funding Rounds

$22.6m

Money raised

Perrone Robotics is a Virginia-based software company.

3

Funding Rounds

$18.0m

Money raised

Astraea is a Charlottesville, Virginia-based company founded in 2016 by Brendan Richardson.

17

Funding Rounds

$63.1m

Money raised

Eiden Systems Corporation is a Charlottesville, VA-based company providing business and technical services to the defense, intelligence, and public safety communities.

9

Funding Rounds

$87.7m

Money raised

Hemoshear Therapeutics is a superior Preclinical Cell Culture founded in 2008 by Brett R. Blackman.

3

Funding Rounds

$31.1m

Money raised

Cavion, Inc is a wholly-owned subsidiary of Jazz Pharmaceuticals plc, which is an international biopharmaceutical company.

1

Funding Rounds

$1.3m

Money raised

HemoSonics is a Charlottesville, Virginia-based medical device company developing tools and supplies for in vitro diagnostics.

3

Funding Rounds

$41.6m

Money raised

Social SafeGuard is a legal name is SafeGuard Cyber, Inc.

4

Funding Rounds

$5.8m

Money raised

Gencia Biotech is an American biopharma company.

2

Funding Rounds

$167.0m

Money raised

Rivus Pharmaceuticals is dedicated to improving cardio-metabolic health by developing controlled metabolic accelerators (CMAs) that address the underlying metabolic risk factors for cardiovascular mortality and morbidity.

1

Funding Rounds

$9.3m

Money raised

Lumacyte is a Virginia-based company focusing on rapid label-free single cell analysis.

2

Funding Rounds

$5.0m

Money raised

Cerillo, Llc is a Charlottesville, Virginia-based company founded in 2016 by Jason Papin, Kevin Seitter and Erik Hewlett.

1

Funding Rounds

$10.0m

Money raised

3Q Digital is a company founded in 2008.

2

Funding Rounds

$5.4m

Money raised

CounterFlow AI is an Artificial Intelligence start-up developing a network forensics platform for threat hunting.

2

Funding Rounds

$4.5m

Money raised

TearSolutions Inc. is a Delaware Corporation based in Charlottesville, VA. The company has successfully completed a well-powered 204 patient Phase II Proof of Concept clinical trial for the treatment of ocular surface disease in primary Sjögren’s Syndrome patients.

1

Funding Rounds

$7.5m

Money raised

Wellaware Systems is a company developing wellness monitoring solutions founded in 2012.

1

Funding Rounds

$450.0k

Money raised

Phthisis Diagnostics is an infectious disease molecular diagnostics company founded by Crystal R Icenhour.

2

Funding Rounds

$3.7m

Money raised

ArcheMedX is a Charlottesville, Virginia-based company founded in 2012 by Joel Selzer.

1

Funding Rounds

Education and personal growth are the heart of WorldStrides’ mission – and they have been since the beginning.

1

Funding Rounds

$2.3m

Money raised

Babylon Micro-Farms is a Charlottesville, Virginia-based company founded in 2017.

3

Funding Rounds

$5.8m

Money raised

Pearl Home Certification is a Charlottesville, Virginia-based energy efficiency company founded in 2015.

1

Funding Rounds

$3.0m

Money raised

RIIG is a risk intelligence and cybersecurity solutions company, that focuses on improving organizational cybersecurity resilience.

Key people:

1

Funding Rounds

Ting Internet offers 100% direct fiber internet for homes and businesses. Watch TV, video call, game and download seamlessly on the fastest and most reliable connection.

1

Funding Rounds

Syntrillo has developed a proprietary artificial intelligence (AI)-driven digital health platform to help prevent stroke.

Key people:

1

Funding Rounds

$1.5m

Money raised

Brightspec, Inc. is a Charlottesville, Virginia-based speciality chemicals company founded in 2012.

3

Funding Rounds

$11.5m

Money raised

Fermata, LLC is a Charlottesville, Virginia-based company founded in 2010.

1

Funding Rounds

$70.0m

Money raised

Pearlx Infrastructure is a Charlottesville, Virginia-based company.

3

Funding Rounds

$12.5m

Money raised

TwinThread, Inc. is a Charlottesville, Virginia-based company founded in 2018.

4

Funding Rounds

$18.9m

Money raised

Tearsolutions Inc. is a Charlottesville, Virginia-based company in the pharmaceuticals industry founded in 2013.

1

Funding Rounds

$2.0m

Money raised

Slate Bio, Inc. is a treg therapy for autoimmune diseases.

1

Funding Rounds

$1.0m

Money raised

SoundPipe, LLC is a Charlottesville, Virginia-based company.

1

Funding Rounds

$3.4m

Money raised

3

Funding Rounds

$1.0m

Money raised

Common House, LLC is a Charlottesville, Virginia-based company founded in 2014.

2

Funding Rounds

$1.7m

Money raised

SCIVERA, LLC is a Charlottesville, Virginia-based company.

1

Funding Rounds

$2.0m

Money raised

ScanOptix, Inc. is a Charlottesville, Virginia-based company founded in 2020.

1

Funding Rounds

$8.5m

Money raised

Denstock Stone View LLC is a Charlottesville, Virginia-based company founded in 2019.

5

Funding Rounds

$5.0

Money raised

MA ENDOWMENT PARTNERS, LP is a Charlottesville, Virginia-based company.

4

Funding Rounds

$4.0

Money raised

MA Partners Fund, LP is a Charlottesville, Virginia-based company.

1

Funding Rounds

$1.0

Money raised

Pula Capital Fund LP is a Charlottesville, Virginia-based company founded in 2019.

1

Funding Rounds

$2.0m

Money raised

Better World Collective is a Charlottesville, Virginia-based fundraising company founded in 2014.

Industries:

1

Funding Rounds

$7.5m

Money raised

Contraline, Inc. is a Charlottesville, Virginia-based company founded in 2017.

1

Funding Rounds

$1.0m

Money raised

Brew Pass Holdings, Inc. is a Charlottesville, Virginia-based company founded in 2019.

1

Funding Rounds

$355.0k

Money raised

Glyphic Redaction Software, Inc. is a Charlottesville, Virginia-based company founded in 2017.

1

Funding Rounds

$1.5m

Money raised

Owl Peak Labs is a cancer company.

1

Funding Rounds

$11.0m

Money raised

Social SafeGuard is a Charlottesville, Virginia-based company.

1

Funding Rounds

Quad-C Management is a Charlottesville, Virginia-based company founded in 1989.

1

Funding Rounds

$1.0m

Money raised

SCIVERA, LLC is a Charlottesville, Virginia-based company.

1

Funding Rounds

$70.0k

Money raised

Hava Technologies LLC is a Charlottesville, Virginia-based company founded in 2020.

1

Funding Rounds

$3.0m

Money raised

PLS INC. is a Charlottesville, Virginia-based company.

1

Funding Rounds

$4.0m

Money raised

Starchive is a Charlottesville, Virginia-based company.

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