69 Best Startups in Houston to Watch in 2025

The Definitive Seedtable Ranking of Startups in Houston

We track 71,000+ companies and rank them dynamically using our Seedtable Score – a score that uses quantitative and qualitative data points to signal the momentum behind a company. We then monitor the list manually leveraging our expertise as founders and investors.

There are 312 start-ups with an aggregate funding of $3.9b. The average funding per company in this subset is $56.3m.

Last update to the database: Feb 18, 2025. See changelog.

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1

Funding Rounds

$100.0k

Money raised

Lazarus 3D provides medical training and surgery rehearsal services through their soft-tissue 3D printed models built using MRI or CT images of patient anatomy.

2

Funding Rounds

$161.5k

Money raised

Orian Span was a commercial space agency that aimed to become the first company to place luxury hotel in space.

Key people:

1

Funding Rounds

Hylio is a technology company making drones for aerial crop spraying.

9

Funding Rounds

$474.1m

Money raised

Solugen is a speciality chemical manufacturing company developing aiming to replace petroleum-based chemicals with alternatives made from plant-based substitutes.

1

Funding Rounds

$1.5m

Money raised

Innovative Biochips (iBioChips) is a Sugar Land, Texas-based biotechnology company developing biosensors and lab-on-chip bioassays.

6

Funding Rounds

$190.5m

Money raised

Kuur Therapeutics focuses on the development of CAR-NKT cell therapies platform for applications in cancer treatment.

5

Funding Rounds

$73.7m

Money raised

Arundo provides software to enable advanced analytics in industrial companies. Arundo's customers transform their businesses through predictive analytics, deeper understanding of physical operations, and data-driven SaaS applications.

4

Funding Rounds

$50.3m

Money raised

Accelergy is a developer of low carbon, synthetic distillate liquids and transportation fuels at a lower cost to the environment and the consumer.

Location:

8

Funding Rounds

$166.0m

Money raised

Axiom Space is a company that is primarily interested in providing human spaceflight services

Key people:

2

Funding Rounds

$7.4m

Money raised

Glycos Biotechnologies, founded in 2007, now known as GlycosBio, is a biotechnology company based in Houston, Texas . GlycosBio Asia is a subsidiary based in Malaysia .

3

Funding Rounds

$475.0m

Money raised

Receivables and Treasury cloud software, powered by AI to optimize working capital.

Key people:

2

Funding Rounds

$750.0m

Money raised

Business service management software

5

Funding Rounds

$129.3m

Money raised

Gecko Robotics is helping the world’s most important organizations ensure the availability, reliability, and sustainability of critical infrastructure.

Key people:

3

Funding Rounds

$6.1m

Money raised

Tavus is a Monterrey, Mexico-based software company offering a platform for developing AI-generated videos with personalized messages.

Location:

Key people:

4

Funding Rounds

$2.6m

Money raised

Commercial space company with a focus on satellite development, deployment, and commercial payload integration.

Key people:

1

Funding Rounds

Craiyon is an artificial intelligence image generator capable of generating images from text prompts.

3

Funding Rounds

$18.0m

Money raised

Topl is a stablecoin cryptocurrency pegged to products and utilities founded in 2017 by Christopher Georgen, James Aman, Nicholas Edmonds and Kim Raath.

7

Funding Rounds

$153.1m

Money raised

Pioneer of autonomous unmanned aerial vehicle (UAV) hardware and software platform providing fully-automated aerial data collection and analysis.

Key people:

3

Funding Rounds

$11.7m

Money raised

A company developing and manufacture laser and MRI-guided technology products

Key people:

4

Funding Rounds

$35.2m

Money raised

Vivante Health is a digital health company.

Location:

Key people:

1

Funding Rounds

$1.2m

Money raised

Luminare is a company that offers software solutions to hospitals for the treatment of of sepsis.

5

Funding Rounds

$14.8m

Money raised

Fluidity Technologies is an Houston-based human-machine interfaces company.

Location:

Key people:

3

Funding Rounds

$103.0m

Money raised

NuProbe is a Cambridge, Massachusetts-based molecular diagnostics company focused on accelerating precision diagnostics.

1

Funding Rounds

Cemvita Factory is an Houston-based clean technology company founded by Moji Karimi and Tara Karimi.

3

Funding Rounds

BioLum Sciences is a Dallas-based medical device company developing chronic illness management products.

3

Funding Rounds

$26.0m

Money raised

SpectraSensors is an Houston-based company founded in 1999.

Location:

1

Funding Rounds

$6.0m

Money raised

Timeseer.AI is an AI/ML based Robo advisory for Time-Series Analytics founded in 2020 by Bert Baeck.

Location:

Key people:

1

Funding Rounds

$40.0k

Money raised

re3D is a company founded in 2013 by Matthew Fiedler.

Key people:

2

Funding Rounds

$620.0k

Money raised

RecycleMatch is a developer of a marketplace for recyclables, industrial byproducts and other waste products.

Location:

Key people:

2

Funding Rounds

$28.8m

Money raised

Syzygy is a Houston, Texas-based decarbonization technology company developing a photocatalytic chemical reactor for the industrial gas, chemical, and energy industries.

Location:

Key people:

6

Funding Rounds

$40.6m

Money raised

Spruce is a mobile concierge platform for apartment communities.

1

Funding Rounds

$2.2m

Money raised

Rhaeos is a shunt Monitor founded in 2018 by John Rogers, Amit Ayer and Siddharth Krishnan.

3

Funding Rounds

$63.0m

Money raised

InGeneron is a regenerative medicine company based in Houston, Texas.

1

Funding Rounds

Clearway Energy owns and operates more than 8 gigawatts of renewable and conventional energy assets across the country.

2

Funding Rounds

$5.9m

Money raised

Cognitive Space is a company founded in 2018 by Guy de Carufel.

Key people:

1

Funding Rounds

$22.2m

Money raised

Essentium combines 3D printing with traditional manufacturing to create industrial 3D printing solutions at scale

1

Funding Rounds

$8.0k

Money raised

Volt Markets is a blockchain company founded in 2016 by Rob Hitchens, Dan Nossa and James Duchenne.

2

Funding Rounds

$14.0m

Money raised

GoCo is an HR platform service based in Houston.

4

Funding Rounds

$19.0m

Money raised

Operator of an AI-driven construction-planning technology company designed for digitization in the construction industry. The company offers an efficient, advanced, and scalable service using artificial intelligence and data-driven methodologies.

1

Funding Rounds

KNOLSKAPE Solutions is a company founded in 2008 by Rajiv Jayaraman.

5

Funding Rounds

$33.3m

Money raised

Data Gumbo is a blockchain company founded in 2016 by Andrew Bruce.

4

Funding Rounds

$66.2m

Money raised

Foro Energy

Key people:

6

Funding Rounds

$30.9m

Money raised

A company offering neurocognitive assessments and cognitive care solutions.

Key people:

2

Funding Rounds

$32.0k

Money raised

AgileDD is at the forefront of AI-powered document intelligence. We understand the challenges organizations face when crucial information is buried in complex technical documents. That's why we've developed powerful solutions that combine AI technology with human expertise to extract and leverage data from diverse document sources

Location:

Key people:

2

Funding Rounds

$32.3m

Money raised

Imubit is a company founded in 2016 by Meir Tseitlin.

Key people:

1

Funding Rounds

Luminostics is a San Jose, California-based developer of a hardware and software platform for smartphone-based home testing, point-of-care testing and global health applications.

1

Funding Rounds

$250.0k

Money raised

A company developing magnetic cell culture technology solutions for three-dimensional (3D) cell culture

2

Funding Rounds

$9.9m

Money raised

Voyager is a company founded in 2018.

Industries:

Location:

6

Funding Rounds

$3.9m

Money raised

Wise Athena is a company founded in 2013 by Alfonso Vazquez, Iosu Santurtun, Octavio Hinojosa and Ricardo Flores.

Key people:

1

Funding Rounds

$1.5m

Money raised

SkillGigs is a sourcing and recruiting platform that uses artificial intelligence to connect professionals looking for jobs with companies looking for candidates.

Location:

Key people:

2

Funding Rounds

$5.6m

Money raised

Senscient is a company that manufactures safety gear.

Key people:

6

Funding Rounds

$52.0m

Money raised

Liongard automates the management and protection of modern IT environments at scale for IT MSPs - Managed Service Providers and Enterprise IT Operations.

1

Funding Rounds

$15.0m

Money raised

Cord Blood Cell Therapy

2

Funding Rounds

$1.4m

Money raised

Cosine is a company that focuses on building 3D printers and providing large-scale 3D printing services to individuals and businesses.

Location:

Key people:

2

Funding Rounds

$450.0m

Money raised

Microvast is a Huzhou-based electrical and electronic manufacturing company.

Key people:

2

Funding Rounds

$7.2m

Money raised

Platform offering SaaS-based solutions for managing energy data and generating energy insights.

Key people:

2

Funding Rounds

$24.2m

Money raised

Innowatts is creating a smarter, leaner energy value chain and transforming the way energy is bought, sold, managed and consumed.

Location:

Key people:

1

Funding Rounds

$4.0m

Money raised

Allotrope Medical is a medical device company focused on smooth muscle stimulation technology. It has developed an intuitive hand-held device for identifying ureters during a surgical procedure. It participated in the YC S18 cohort of Y Combinator.

1

Funding Rounds

$5.8m

Money raised

TerraPass is a San Francisco-based nonprofit organization offering projects for environmental cleanup and carbon offset.

4

Funding Rounds

$60.3m

Money raised

GoExpedi is an Houston-based company founded by Timothy Neal.

Location:

Key people:

1

Funding Rounds

$2.3m

Money raised

Developing novel, bioresorbable smart polymers to transform vascular surgery

Key people:

2

Funding Rounds

Valhalla Healthcare is an artificial Intelligence company founded in 2017 by Alexeis Baqui.

1

Funding Rounds

$11.0m

Money raised

Alzeca Biosciences is a Houston-based healthcare diagnostics company developing imaging agents for the diagnostics of neurodegenerative diseases.

Location:

Key people:

2

Funding Rounds

$7.9m

Money raised

Operator of a clinical care labor platform intended to connect communities with clinical and hospitality talent. The company's platform permits post-acute caregivers to earn extra income, and manage their own flexible schedules by providing access to assisted living and skilled nursing facilities in an area, reducing overtime wages.

Location:

Key people:

2

Funding Rounds

$86.1k

Money raised

Tomowave Laboratories, Inc. is an Houston-based company founded in 2010 by Alexander Oraevsky.

Location:

Key people:

2

Funding Rounds

$25.0m

Money raised

SiteAware is a company founded in 2015 by Ori Aphek.

Industries:

Location:

Key people:

2

Funding Rounds

$12.5m

Money raised

Developer of e-billing products to law firms. The company offers Passport, a platform for uniting legal systems; Advanced Invoice Management System, a legal spend management system; and Corporate Legal Desktop, an integrated matter and legal spend management solution. It also offers consulting and hosting services.

2

Funding Rounds

$200.0k

Money raised

Arch Aerial is an Houston-based company founded in 2012 by Ryan Baker.

Location:

Key people:

4

Funding Rounds

$129.5m

Money raised

OncoResponse is a company providing cancer research into immunotherapies and the newest technologies for oncologists.

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