69 Best Startups in Philadelphia to Watch in 2025

The Definitive Seedtable Ranking of Startups in Philadelphia

We track 71,000+ companies and rank them dynamically using our Seedtable Score – a score that uses quantitative and qualitative data points to signal the momentum behind a company. We then monitor the list manually leveraging our expertise as founders and investors.

There are 231 start-ups with an aggregate funding of $4.3b. The average funding per company in this subset is $62.5m.

Last update to the database: Feb 18, 2025. See changelog.

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9

Funding Rounds

$474.1m

Money raised

Solugen is a speciality chemical manufacturing company developing aiming to replace petroleum-based chemicals with alternatives made from plant-based substitutes.

6

Funding Rounds

$21.8m

Money raised

Aromyx is a biotechnology company developing a biosensor for human tase and olfactory receptors.

5

Funding Rounds

$70.8m

Money raised

QuotaPath is a software company specializing in developing solutions to track sales commissions.

4

Funding Rounds

Because Animals is a pet food and cellular agriculture technology company founded in 2016 by Shannon Falconer and Joshua Erret, and is located in Philadelphia, Pennsylvania. Because Animals makes 100% animal-free pet foods, treats, and supplements.

5

Funding Rounds

$425.0m

Money raised

Tmunity Therapeutics is a biotechnology company developing t-cell immunotherapies for the treatment of human diseases.

1

Funding Rounds

$2.0m

Money raised

Allevi, formerly known as BioBots, is a technology company making 3 dimensional bioprinters and bioinks for their printers. The company was founded in 2014 and located in Philadelphia, Pennsylvania.

2

Funding Rounds

$6.3m

Money raised

Stix is a company providing mail-order pregnancy and fertility tests with discretion. It was founded in 2018 and is located in Philadelphia, Pennsylvania.

1

Funding Rounds

$3.0m

Money raised

A cloud-based technology company that aids entities with rewards programs to reach their audiences more efficiently. It is located in Philadelphia and was founded in 2016.

2

Funding Rounds

$300.0k

Money raised

Biomeme is a Philadelphia-based developer of a DNA analysis for smartphone.

3

Funding Rounds

$1.9m

Money raised

Life.io is a Princeton, New Jersey-based customer engagement and data analytics platform developer for the life and health insurance company.

5

Funding Rounds

$120.2m

Money raised

Crossbeam is a collaborative data platform that helps companies build more valuable partnerships.

Key people:

1

Funding Rounds

$16.0m

Money raised

A pharmaceutical company that develops topical products to treat rare diseases

3

Funding Rounds

$36.5m

Money raised

Covenant Surgical Partners is a company that operates ambulatory surgery centers founded in 2008.

1

Funding Rounds

$2.3m

Money raised

Orai is an company that utilizes artificial intelligence to coach people into becoming more effective and confident communicators

2

Funding Rounds

$21.0m

Money raised

Sidecar is a Philadelphia-based company founded by Andre Golsorkhi.

5

Funding Rounds

$3.4m

Money raised

Asylon provides solutions for the autonomous UAV industry.

2

Funding Rounds

$112.0m

Money raised

Carisma Therapeutics is a biotechnology company founded in 2016 to bring the potheyr of adoptive cellular immunotherapy to solid tumor patients through a novel platform using chimeric antigen receptor macrophages (CARMA).

3

Funding Rounds

$10.8m

Money raised

NeuroFlow is a Philadelphia-based company founded in 2017 by Adam Pardes.

2

Funding Rounds

$3.8m

Money raised

RoundTrip is a company that has developed a digital transportation marketplace for better health outcomes.

3

Funding Rounds

$70.8m

Money raised

Excision BioTherapeutics is a company founded in 2015 and headquartered in Philadelphia.

5

Funding Rounds

$68.9m

Money raised

Guru is a software company making a knowledge management tool founded in 2013.

3

Funding Rounds

$21.9m

Money raised

Deduce is a New York City-based cybersecurity company.

1

Funding Rounds

$3.8m

Money raised

A visual search and 3D real-world product recognition platform.

5

Funding Rounds

$5.4m

Money raised

Kickup is a Philadelphia-based company founded in 2014 by Jeremy Rogoff, Victoria Kinzig and Eric Krupski.

4

Funding Rounds

$241.9m

Money raised

Asklepios Biopharmaceutical is a company in North Carolina.

7

Funding Rounds

$3.9m

Money raised

Sapient Industries is a company that offers Sapient system, an enterprise plug load management and analytics system that uses machine learning technology.

3

Funding Rounds

$42.3m

Money raised

A software company with a focus on analytics engineering. It was founded in 2016 and is located in Philadelphia, Pennsylvania.

1

Funding Rounds

$1.2m

Money raised

Brainvectis is a biotechnology company developing treatments for neurodegenerative diseases through restoring cholesterol metabolism in the brain.

2

Funding Rounds

$12.8m

Money raised

The Neat Company is a company founded in 2002.

4

Funding Rounds

$34.0m

Money raised

Developer of a real estate brokerage platform designed to ease the process of home buying and selling. The company's platform streamlines the entire transaction from beginning to end with an integrated one-stop shopping experience wherein the full-service, salaried agents and loan officers receive salaries instead of commissions, enabling clients to save time and money in the process.

5

Funding Rounds

$119.3m

Money raised

Proscia makes digital pathology software and AI applications for cancer diagnosis.

4

Funding Rounds

$414.4m

Money raised

Dbt Labs is a Philadelphia-based company founded in 2016 by Tristan Handy, Drew Banin and Connor McArthur.

5

Funding Rounds

$27.4m

Money raised

A company offering a threat detection platform using artificial intelligence to detect people with weapons.

9

Funding Rounds

$102.8m

Money raised

InstaMed is a Philadelphia-based company founded in 2004.

1

Funding Rounds

$20.0k

Money raised

CloudMine is a Philadelphia-based company founded in 2011 by Marc Weil, Ilya Braude and Brendan McCorkle.

1

Funding Rounds

$16.0m

Money raised

Exyn is a startup developing autonomous aerial robots founded in 2014.

2

Funding Rounds

$3.7m

Money raised

Reflect is a no-code tool for automated website testing.

2

Funding Rounds

$97.5m

Money raised

SparingVision is a retinal Gene Therapy Treatments founded by Jose alain sahel.

4

Funding Rounds

$69.9m

Money raised

A company that develops molecular imaging agents to detect and monitor chronic human diseases

4

Funding Rounds

$192.4m

Money raised

Imvax is a clinical-stage biotechnology company focused on the development of patient-specific vaccines and immunotherapy strategies for the treatment of malignant gliomas and other cancers with unmet medical needs.

2

Funding Rounds

$1.5m

Money raised

TicketLeap is a Philadelphia-based company founded in 2023 by Chris Stanchak.

Location:

Key people:

4

Funding Rounds

$56.6m

Money raised

​LearnUpon is a learning management system founded in 2012 by Brendan Noud.

5

Funding Rounds

$543.0m

Money raised

Misfits Market is a New Jersey-based company and online grocery platform founded by Abhi Ramesh.

1

Funding Rounds

$20.0m

Money raised

LiquidHub is a Philadelphia-based company founded in 2001.

1

Funding Rounds

$10.0m

Money raised

Hi there, my name is Young Alfred. Iïm on a mission to turn the 5 hour nightmare of shopping for home insurance online into an informed 15 minute transaction. With over 40 direct insurance carrier partners already on our platform, Young Alfred is built to serve each and every homeowner in America. At your service, Young Alfred

2

Funding Rounds

$1.3m

Money raised

Pera Labs is a fertility technology company offering artificial intelligence and lab-on-chip technology for detecting reproductive health problems and allow users to select for sex.

3

Funding Rounds

$62.3m

Money raised

Scout Bio is a biotechnology company that focuses on transforming pet medicine by providing a pipeline of therapeutics for chronic pet health conditions.

5

Funding Rounds

$170.0m

Money raised

HealthVerity is a Philadelphia-based company founded in 2014 by Andrew Goldberg.

3

Funding Rounds

$500.0k

Money raised

Infrascan, Inc. is a Philadelphia-based medical device company focused on developing hand-held diagnostic devices for head injury and stroke assessment founded in 2004.

3

Funding Rounds

$139.0m

Money raised

Limelight Bio is a biopharmaceutical company researching and developing novel gene therapy technologies.

1

Funding Rounds

$202.0k

Money raised

Fitly is the developer of SmartPlate, a platform leveraging artificial intelligence for nutrition.

3

Funding Rounds

$2.8m

Money raised

Group K Diagnostics is a Philadelphia-based manufacturer of point-of-care diagnostic tools.

3

Funding Rounds

$2.8m

Money raised

A Philadelphia-based company that offers graphene for industrial and commercial applications

2

Funding Rounds

$1.1m

Money raised

maroon.ai is a Philadelphia-based company founded by Ankit Sharma, Mehul Dhikonia and Ranjith Sivaraman.

3

Funding Rounds

$18.5m

Money raised

MD Ally develops a telehealth emergency care platform to offer ease of access between public safety practitioners and providers.

4

Funding Rounds

$15.0m

Money raised

Panorama Medicine, Inc. specializes in the development of new drug discovery solutions based on genomics and computing.

4

Funding Rounds

$4.2m

Money raised

Deepwave Digital, Inc. is an AI developing company.

3

Funding Rounds

$5.0m

Money raised

Invite Media is a Philadelphia-based advertising company founded in 2007 by Zach Weinberg, Scott Becker, Michael Provenzano and Nat Turner.

6

Funding Rounds

$183.4m

Money raised

Phenom People is a company founded in 2010.

2

Funding Rounds

$6.3m

Money raised

Strados Labs is a respiratory Management Device founded in 2016 by Nick Delmonico, Yu Kan AU and Tanziyah Muqeem.

3

Funding Rounds

$11.7m

Money raised

Formotiv is a behavioral intelligence company developing digital body language as a method to predict and prevent risk and fraud.

3

Funding Rounds

$67.7m

Money raised

Ophelia is a company founded in 2019 by Mattan Griffel.

1

Funding Rounds

$1.5m

Money raised

Switchboard Live is a Philadelphia-based company founded in 2016 by Rudiger J. Ellis, Joshua Sachs and Jason Kotte.

2

Funding Rounds

$81.5m

Money raised

Novel methods for in vivo cell-specific gene delivery

2

Funding Rounds

Authentise is a company founded in 2012 by Andre Wegner, Karla Lopez and Ann Rogan.

2

Funding Rounds

Woveon is a company founded in 2016 by Chadwick "Doc" Wingrave, David Dinh and Adam Rawot.

4

Funding Rounds

$14.6m

Money raised

Strella Biotechnology offers a biosensing platform that predicts the ripeness of fruit which reduces food waste and improves quality.

Location:

Key people:

1

Funding Rounds

$6.0m

Money raised

Weblinc E-Commerce is a Philadelphia-based company founded in 1994.

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