69 Best Startups in South Carolina to Watch in 2025

The Definitive Seedtable Ranking of Startups in South Carolina

We track 71,000+ companies and rank them dynamically using our Seedtable Score – a score that uses quantitative and qualitative data points to signal the momentum behind a company. We then monitor the list manually leveraging our expertise as founders and investors.

There are 134 start-ups with an aggregate funding of $987.9m. The average funding per company in this subset is $14.3m.

Last update to the database: Feb 18, 2025. See changelog.

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1

Funding Rounds

Doxim is a Markham, Ontario-based customer communications and engagement technology software development company focused on providing omnichannel communications and payment solutions for the financial services industry.

3

Funding Rounds

$5.3m

Money raised

An insurance technology company offering a platform for healthcare organizations to access health insurance data to improve their ability to bring new products and services to market.

8

Funding Rounds

$25.4m

Money raised

Biosortia is a therapeutics, agrochemical and cosmetics company developing products from microbial small molecules through microbiome mining.

2

Funding Rounds

$35.0m

Money raised

Thetanuts Finance is a protocol designed to help users access crypto-structured products on multiple decentralized networks.

3

Funding Rounds

$36.5m

Money raised

Covenant Surgical Partners is a company that operates ambulatory surgery centers founded in 2008.

4

Funding Rounds

$25.7m

Money raised

Choose Energy is a Texas-based marketplace company offering clean technology and service to help consumers shopping for electricity and natural gas rates.

7

Funding Rounds

$1.7m

Money raised

Bandwagon is a Greenville, South Carolina-based company founded in 2015 by Harold Hughes.

Key people:

4

Funding Rounds

$683.0k

Money raised

Iverson Genetics provides diagnostic tools for disease prevention and treatment optimization.

1

Funding Rounds

Ceres is a non-profit organization advocating sustainability founded in 1989 by Joan Bavaria.

2

Funding Rounds

ContaAzul is a company founded in 2012 by João Augusto Zaratine, Vinicius Roveda Gonçalves, José Carlos Sardagna and Marcelo dos Santos.

3

Funding Rounds

$1.2m

Money raised

Dreamweaver International is a company that produces lithium-ion battery separators, founded by Brian Morin.

2

Funding Rounds

$35.0m

Money raised

Palmetto is a company founded in 2008.

2

Funding Rounds

$15.0m

Money raised

Living Carbon is a San Francisco, CA based startup using biotechnology to develop trees that better capture and store carbon.

3

Funding Rounds

$1.0m

Money raised

Senex Biotechnology is a pharmaceutical company founded in 2002.

3

Funding Rounds

$675.0k

Money raised

Dynepic is a Charleston, SC-based company which offers a virtual reality training platform

2

Funding Rounds

$140.0k

Money raised

ReferralMD is a healthcare software developer offering appointment scheduling, referral management, consulting management, patient access, and engagement software solutions.

3

Funding Rounds

$3.8m

Money raised

AtomChat Inc. is a Simpsonville, South Carolina-based company founded in 2019 by Erick Holmann.

Key people:

2

Funding Rounds

$3.5m

Money raised

BeliefNetworks is a software company that is providing access solutions for web publishers, bloggers, and their consumers with access to related content in real-time.

1

Funding Rounds

A company providing software and services to healthcare industry

3

Funding Rounds

$24.2m

Money raised

Case Status is a cloud-based, client management tool for the legal services industry.

Key people:

6

Funding Rounds

$5.0m

Money raised

TerraStride is a mapping platform company that markets TerraStride Pro, a land brokerage solution, and the Huntstand app.

Industries:

Key people:

5

Funding Rounds

$39.8m

Money raised

Ceterus is a company founded by Levi Morehouse.

4

Funding Rounds

$5.6m

Money raised

NanoAvionika, LLC is a company founded by Linas Sargautis.

Key people:

6

Funding Rounds

$201.4m

Money raised

Van Robotics is a company founded by Laura Boccanfuso.

1

Funding Rounds

$500.0k

Money raised

TOTAL MULTIMEDIA INCORPORATED is a technology company specializing in digital video compression and playback software.

6

Funding Rounds

$5.9m

Money raised

GreenWizard is a Charleston, South Carolina-based company founded by Adam Bernholz.

4

Funding Rounds

$4.0m

Money raised

Hank AI, Inc. is a technology developing company.

3

Funding Rounds

$9.4m

Money raised

Modjoul, Inc. is a Clemson, South Carolina-based company founded in 2017 by Eric Martinez.

Key people:

1

Funding Rounds

$500.0k

Money raised

DeepBD Inc. is a computing software company.

3

Funding Rounds

$31.3m

Money raised

ChartSpan Medical Technologies (ChartSpan) is a healthcare software company which provides patient engagement technology and managed medical services for doctor's offices and healthcare providers.

1

Funding Rounds

$21.0m

Money raised

Glytec is a predictive dosing algorithm for diabetes founded in 2006.

1

Funding Rounds

Pathwright is a Greenville, South Carolina-based company founded in 2012.

1

Funding Rounds

$3.4m

Money raised

Zipit Wireless is a Greenville, South Carolina-based company founded in 2002 by Ralph Heredia.

Key people:

2

Funding Rounds

$3.0m

Money raised

A company that develops 3D cell-based models for drug response profiling

1

Funding Rounds

$4.6m

Money raised

Carbonix builds next-generation drones for industry and defence.

$3.2m

Money raised

Questis is the complete personal finance solution that empowers everyone in the employee benefits ecosystem.

8

Funding Rounds

$133.1m

Money raised

Palmetto Clean Technology, Inc. is a Charleston, South Carolina-based company.

2

Funding Rounds

$6.0m

Money raised

Veravas is a manufacturer and supplier of immunoassays.

1

Funding Rounds

At Pure Fishing, we are committed to more than just making world-class fishing gear. We are dedicated to creating a positive impact on our employees, customers, communities, and the environment. Our promise is to:At Pure Fishing, we are committed to more than just making world-class fishing gear. We are dedicated to creating a positive impact on ou

2

Funding Rounds

$9.2m

Money raised

Zylo Therapeutics Inc. is a drug Delivery.

2

Funding Rounds

$12.5m

Money raised

Technology to develop therapeutics that render calcified tissue and organs supple again

1

Funding Rounds

$900.0k

Money raised

A diagnostics company providing molecular and genomic diagnostic services

1

Funding Rounds

$1.2m

Money raised

Trulite, Inc. is a Columbia, South Carolina-based company founded in 2002.

1

Funding Rounds

$2.3m

Money raised

Operator of technology development and licensing company intended to promote light, safe, and cost-effective architecture for lithium-ion batteries.

2

Funding Rounds

$20.0m

Money raised

Sprockets is a Charleston, South Carolina-based company founded in 2016.

1

Funding Rounds

$3.0m

Money raised

Obsidio is a bioinspired Material for Minimally Invasive Medical Procedures.

9

Funding Rounds

$28.6m

Money raised

Heatworks is a company founded in 2006.

3

Funding Rounds

$7.5m

Money raised

Base HQ, Inc. is a company founded in 2018 by Paige McPheely.

1

Funding Rounds

$2.8m

Money raised

Inveterate, Inc is a reinventing loyalty in eCommerce founded in 2021 by Dylan Whitman.

Key people:

1

Funding Rounds

Gnosis Freight provides supply chain visibility and execution software for importers, exporters, and logistics service providers globally.

Key people:

1

Funding Rounds

$15.0m

Money raised

The New Primal is a North Charleston, South Carolina-based jerky company.

1

Funding Rounds

$1.0m

Money raised

Cliently is a Myrtle Beach, South Carolina-based company founded in 2015.

1

Funding Rounds

$1.0m

Money raised

Ellipsis Technologies is a diversified technology company that develops innovative security software for websites and online applications.

1

Funding Rounds

Relify is a Greenville, South Carolina-based company founded by Terry Horner, Andria Trivisonno and John Krebsbach.

1

Funding Rounds

$200.0k

Money raised

A company developing and producing antibody-based therapeutics for viral, bacterial and tumor antigens

2

Funding Rounds

$6.5m

Money raised

ENGAGE Talent is a company founded in 2014.

1

Funding Rounds

Advanced Aircrew Academy provides professional pilots, flight or cabin attendants, flight coordinators, and online training services.

15

Funding Rounds

$69.4m

Money raised

Aseko Inc. is a Greenville, South Carolina-based company.

1

Funding Rounds

$5.0m

Money raised

Mailprotector is a Greenville, South Carolina-based company founded in 1999.

1

Funding Rounds

$4.0m

Money raised

GoodCall is a Fort Mill, South Carolina-based company founded in 2015.

2

Funding Rounds

$12.3m

Money raised

Company

1

Funding Rounds

$39.0m

Money raised

PunchListUSA is a Charleston, South Carolina-based company.

2

Funding Rounds

$4.0m

Money raised

Re Botanicals is a company founded in 2018.

1

Funding Rounds

$22.1m

Money raised

Amplio Group is a Columbia, South Carolina-based company.

1

Funding Rounds

The RAP Index is a Greenville, South Carolina-based company founded in 2008.

1

Funding Rounds

$250.0k

Money raised

PAEROSOL sells and distributes a nanotechnology disinfecting platform that kills air and surface-borne mold, bacteria, and viruses.

3

Funding Rounds

$13.8m

Money raised

BlinkTBI, Inc. is a Charleston, South Carolina-based company founded in 2017.

1

Funding Rounds

PeopLease is a Mount Pleasant, South Carolina-based company.

1

Funding Rounds

$14.0m

Money raised

CBC Partners, LLC is a company founded in 2019.

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