69 Best Startups in Maryland to Watch in 2025

The Definitive Seedtable Ranking of Startups in Maryland

We track 71,000+ companies and rank them dynamically using our Seedtable Score – a score that uses quantitative and qualitative data points to signal the momentum behind a company. We then monitor the list manually leveraging our expertise as founders and investors.

There are 546 start-ups with an aggregate funding of $6.2b. The average funding per company in this subset is $90.1m.

Last update to the database: Feb 18, 2025. See changelog.

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7

Funding Rounds

$60.6m

Money raised

READY Robotics is a company developing an industrial brand-agnostic operating system (Forge/OS) for industrial robots and automation.

1

Funding Rounds

$60.0m

Money raised

7

Funding Rounds

$267.5m

Money raised

Immuta is a Boston-based provider of a cloud-native data governance platform for organizations to automate data access control, security, and privacy compliance.

1

Funding Rounds

Amentum is a technical and engineering services partner working with the United States defense, security, intelligence, energy, and environmental programs.

6

Funding Rounds

$356.3m

Money raised

Insilico Medicine is a drug discovery, artificial intelligence company that looks to treat cancer and age related diseases

5

Funding Rounds

$76.5m

Money raised

A clinical-stage biopharmaceutical company engaging in drug discovery and drug development for treating autoimmune disease and cancer.

5

Funding Rounds

$40.0m

Money raised

Enveil is a Fulton, Maryland-based data security and privacy security technology company.

3

Funding Rounds

$21.5m

Money raised

RoosterBio is a biotechnology company located in Frederick, Maryland, founded by Jon Rowley in 2013 providing standardized stem cell products for R&D, clinical, and commercial use in the regenerative medicine industry.

5

Funding Rounds

$2.3m

Money raised

An app that aggregates social media data to produce a real-time map of sickness.

3

Funding Rounds

$26.8m

Money raised

ISARA is a company developing quantum computer resistant software products founded in 2015 by Scott Totzke.

4

Funding Rounds

$20.5m

Money raised

Zeteo Tech is a company founded by Charles Call.

1

Funding Rounds

$3.7m

Money raised

Dispatch Goods excludes disposable foodware from food delivery by coordinating into food delivery apps.

2

Funding Rounds

$27.4m

Money raised

A nonprofit genomic research institute dedicated to advances in human health and the environment.

1

Funding Rounds

Nayax is a global FinTech company, developing solutions for the unattended machine industry. Nayax's cashless payments, telemetry, management & BI solutions fits to any machine from around the globe. Established in 2005, Nayax has over 250,000 devices installed worldwide, operating in more than 50 countries and 26 currencies and offers local support and ensure that all our customers receive the highest level of service in their local region. Attending the Unattended: Unattended machines, an unattended customer. Nayax's line of innovative products are designed (in-house) to remotely manage the machines and bring you closer to your customer. Nayax offers cashless and telemetry solutions including debit and credit cards, mobile, SMS, prepaid cards and NFC payment options. Point-of-sale options include swipe, contact or contactless card payment methods. Accepting virtually all forms of payment. No need to deal with banks, credit fees, telecom payments and more. Nayax works with leading global payment processors in order to provide the best cashless services at highly competitive rates. Function and benefits: The Nayax management & BI suite allows for online machine management, real time status reports and customized alerts for different machine events such as vend outs, low/high temperature. Advanced analytics tools provide actionable insights including the ability to forecast inventory issues based on historical data and compare products and costs while seeing growth in sales by location. Visit-to-visit reports enable smarter machine management without spending time and money on unnecessary trips. Nayax is constantly developing innovative approaches to surpass industry expectations and create loyalty between consumers and machine operators. Nayax listens to its customers to ensure satisfaction. The development, sales and support processes are customer oriented to contribute to the company's growth strategy.

1

Funding Rounds

Digital Harmonic develops video delivery, image enhancement and signal processing solutions for commercial, government and healthcare sectors.

Key people:

1

Funding Rounds

$2.0m

Money raised

A&G Pharmaceutical is a Columbia, Maryland-based theranostics company developing personalized cancer therapeutics through cancer-specific monoclonal antibodies.

2

Funding Rounds

$4.7m

Money raised

Biotechnology company providing protein analysis tools and commercializing diagnostic tests

3

Funding Rounds

$32.0m

Money raised

Agrimetis Llc is a biotech company that develops crop protection products founded in 2014 by Philip Goelet, Brian Green and Simon Aspland.

3

Funding Rounds

$37.0m

Money raised

Quantum Xchange is a quantum fiber network that is based in the United States. It uses photons of light to physically transfer a shared secret between two entities.

2

Funding Rounds

$60.6m

Money raised

A biotechnology company developing nucleic acid immunotherapy platform and protein based vaccines

2

Funding Rounds

$20.4m

Money raised

A company providing the digital infrastructure for distributing earth observation data and derived intelligence.

3

Funding Rounds

$36.5m

Money raised

Covenant Surgical Partners is a company that operates ambulatory surgery centers founded in 2008.

3

Funding Rounds

$303.0m

Money raised

Robotic Research develops autonomy and robotic technology to improve the safety, security, and effectiveness of transportation.

1

Funding Rounds

$2.0m

Money raised

A biotechnology company founded in 2006 and based in Baltimore, MD, that develops polymers to deliver DNA and RNA therapeutics.

4

Funding Rounds

$120.9m

Money raised

Sonatype is a Fulton, Maryland-based cybersecurity company helping enterprises get precise intelligence about open source components and software security.

1

Funding Rounds

$3.0m

Money raised

An artificial intelligence and biotechnology company developing software and offering laboratory services related to the diagnoses, treatment, and cost reduction of managing human diseases.

7

Funding Rounds

$52.4m

Money raised

Protenus is a company that participated in the DreamIT Ventures - Health Baltimore 1/1/14 cohort .

4

Funding Rounds

$6.0m

Money raised

AGT is developing and commercializing gene and cell therapy and targeting major diseases, including HIV/AIDS, Phenylketonuria (PKU) and Hepatocellular carcinoma.

$80.0m

Money raised

/PRNewswire/ -- Parry Labs, LLC, a defense technology company that develops next generation open architecture mission solutions, announced today the completion...

4

Funding Rounds

$10.0m

Money raised

Salsa Labs is a company founded in 2003 by Chris Lundberg.

10

Funding Rounds

$460.8m

Money raised

Aledade is a company founded in 2014.

2

Funding Rounds

$22.0m

Money raised

Veralox Therapeutics is a small molecule drug discovery and development firm based in the Frederick Innovative Technology Center, Inc.

5

Funding Rounds

$153.5m

Money raised

ZeroFOX is a digital Risk Protection Platform founded in 2013 by James Foster, Robert Francis, Evan Blair, Chris Cullison and Hillary Herlehy.

5

Funding Rounds

$127.6m

Money raised

Omniome is a San Diego-based company.

2

Funding Rounds

$40.0m

Money raised

AsclepiX Therapeutics is a Baltimore-based biotechnology company developing therapeutics for the treatment of retinal diseases and cancer.

6

Funding Rounds

$5.1m

Money raised

A proteomics-based diagnostics company providing research services for the development of personalized medicine

3

Funding Rounds

$47.6m

Money raised

Netography is a company that provides network security platforms

3

Funding Rounds

$1.4b

Money raised

Resilience Technology Corporation is an Hanover, Maryland-based cybersecurity company developing and manufacturing cyber security tools and founded in 1995.

4

Funding Rounds

$20.5m

Money raised

Edgybees is a company that develops augmented reality technologies.

2

Funding Rounds

$7.2m

Money raised

emocha Mobile Health is a company founded in 2008 by Jeff Daley, Morad Elmi, Sharon Kong, Sebastian Seiguer and Gorkem Sevinc.

1

Funding Rounds

$1.2m

Money raised

Hatchfi is a developer API for connecting your users' crypto wallets and accounts to your application with just a few lines of code.

3

Funding Rounds

$7.3m

Money raised

CosmosID is a microbial genomics platform focused on characterization of microorganisms, pathogens and anti-microbial resistance for infectious disease identification, food safety inspections, pharmaceutical discovery, public health surveillance and microbiome analysis.

1

Funding Rounds

$15.0m

Money raised

Lotame is a data connectivity solutions provider.

12

Funding Rounds

$479.3m

Money raised

Personal Genomics is a medical diagnostics company developing tissue-based and liquid biopsy genomic products for laboratory and diagnostic applications.

3

Funding Rounds

$13.9m

Money raised

Elixirgen Therapeutics is a Baltimore-based biotechnology company.

1

Funding Rounds

$5.3m

Money raised

Precision Biologics is a company developing therapeutic and diagnostic products founded in 2012 by Dr. Myron Arlen.

3

Funding Rounds

$156.0m

Money raised

Forty Seven is a Foster City, California-based company founded in 1987.

1

Funding Rounds

$5.0m

Money raised

JackBe is a Chevy Chase, Maryland-based company founded in 2010.

2

Funding Rounds

$950.0k

Money raised

An operator of a biotechnology company in Massachusetts that focuses on improving the manufacture of immuno-therapeutics and dendritic cell-based vaccines.

3

Funding Rounds

$326.1m

Money raised

Delfi Diagnostics is a Baltimore, Maryland based company whose mission is to develop a blood test for cancer detection

1

Funding Rounds

$550.0k

Money raised

Company

2

Funding Rounds

$7.5m

Money raised

Wealthengine is a Bethesda, Maryland-based company.

1

Funding Rounds

$150.0k

Money raised

Zergo is developing nanotechnology sensors for fertility and wellness.

2

Funding Rounds

$8.5m

Money raised

PepVax Inc. is a Washington DC-based biotechnology company.

1

Funding Rounds

$12.0m

Money raised

Webs is a Silver Spring, Maryland-based company founded in 2001.

1

Funding Rounds

$5.0m

Money raised

WindMIL Therapeutics is a biotechnology company developing cell therapy products for treating cancer.

2

Funding Rounds

$20.3m

Money raised

A company that provides reagents, services and training for scientists for cellular reprogramming

3

Funding Rounds

$33.2m

Money raised

Xona Space Systems builds navigation solutions to supports safety-critical operations, centimeter positioning, and cybersecurity.

1

Funding Rounds

$82.0m

Money raised

A company developing diagnostic products.for clinical laboratories and life science researchers.

11

Funding Rounds

$91.9m

Money raised

A company that offers DNA analysis and genome mapping system

2

Funding Rounds

$43.6m

Money raised

Yalochat is an artificial Intelligence company founded in 2015 by Javier Mata.

7

Funding Rounds

$95.4m

Money raised

Securrency is a global financial services technology infrastructure and products company.

4

Funding Rounds

$183.0m

Money raised

Facet Wealth provides full financial life management, delivered by a dedicated team led by a CFP Professional, to mass affluent households. We also work with financial services professionals as a solution for small accounts.

11

Funding Rounds

$45.9m

Money raised

Vorbeck Materials is a Jessup, Maryland-based company founded by John S. Lettow.

7

Funding Rounds

$104.4m

Money raised

Adaptive Phage Therapeutics is a phage treatments targeting multi-drug resistant bacteria founded in 2016 by Greg Merril.

3

Funding Rounds

$460.0k

Money raised

Equinox Innovative Systems is a Telecommunications company based in Columbia, Maryland.

5

Funding Rounds

$34.8m

Money raised

Cybrary is a College Park, Maryland-based career development platform in cybersecurity and information technology applications.

2

Funding Rounds

$30.0m

Money raised

Sandvine is a company that offers visibility into network traffic.

6

Funding Rounds

$358.2m

Money raised

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