69 Best Startups in Missouri to Watch in 2025

The Definitive Seedtable Ranking of Startups in Missouri

We track 71,000+ companies and rank them dynamically using our Seedtable Score – a score that uses quantitative and qualitative data points to signal the momentum behind a company. We then monitor the list manually leveraging our expertise as founders and investors.

There are 249 start-ups with an aggregate funding of $3.9b. The average funding per company in this subset is $57.2m.

Last update to the database: Feb 18, 2025. See changelog.

See all results for this search

Track over 71,000 companies

Discover
Fast-growing Global startups

Seedtable uses technology and people to track over 71,000 companies to help you find the right ones to partner with.

Pricing + Sign up

5

Funding Rounds

$2.3m

Money raised

An app that aggregates social media data to produce a real-time map of sickness.

1

Funding Rounds

$25.0m

Money raised

Hungry Planet is a food technology startup company founded in 2016 by siblings Todd and Jody Boyman. Hungry Planet is located in St.Louis, Missouri, and produces plant-based meats. The company offers beef, Italian sausage, chorizo, chicken, pork, crab and turkey - available in chubs (ground), crumble and patties.

2

Funding Rounds

$50.0m

Money raised

Neighborly drives investment in world-positive infrastructure projects like broadband, solar microgrids, and libraries.

6

Funding Rounds

$46.0m

Money raised

A company using RNA to diagnose disease and to develop biomarkers that predict treatment outcomes. Cofactor is founded by Jarret Glasscock.

5

Funding Rounds

$3.4m

Money raised

S4 is a Buenos Aires-based agricultural technology company providing risk management, data analytics, and growth prediction platforms.

4

Funding Rounds

$3.5m

Money raised

Blanket is a Miami-based sales automation company with a distributed team.

5

Funding Rounds

$30.9m

Money raised

Horizon Discovery is a company that offers gene editing, CRO, and diagnostics services

2

Funding Rounds

$20.0m

Money raised

Zeno Power Systems is an Arlington, Virginia-based developer of a radioisotope power system intended to convert heat from recycled nuclear waste into electricity.

9

Funding Rounds

$222.0m

Money raised

SafetyCulture is a software for mobile workplace safety and quality management.

5

Funding Rounds

$65.4m

Money raised

An agricultural biotechnology company producing renewable, biomass-based fuels and raw materials

10

Funding Rounds

$637.7m

Money raised

C2FO, the world's market for working capital and risk-free profit, is the only working capital exchange that allows companies to optimize their working capital positions in a live marketplace. Companies across the globe use C2FO to increase their gross and net profit while simultaneously producing working capital flows to their supply chain. C2FO is Collaborative Cash Flow Optimization.

5

Funding Rounds

$67.5m

Money raised

A health care provider in Missouri that focuses on continuous primary care online.

1

Funding Rounds

$1.0m

Money raised

Fragma is a Douglas County, Missouri-based company founded in 2021.

9

Funding Rounds

$81.0m

Money raised

A medical diagnostics company that develops biological assay platform for measuring clinical and point-of-care samples

2

Funding Rounds

$3.0m

Money raised

Bellwethr is a business process automation and customer decision optimization company.

1

Funding Rounds

$14.1m

Money raised

Zaarly is a company founded in 2011.

3

Funding Rounds

$8.5m

Money raised

Daupler is Kansas City, Missouri based company developing response software for utilities, public works, and other service organizations.

4

Funding Rounds

$334.0m

Money raised

CRB is a leading provider of engineering, architecture, construction and consulting solutions, delivering safe, high-quality,...

8

Funding Rounds

$20.9m

Money raised

TCARE is a software platform for preventing burnout for caregivers founded in 2014 by Vijay Anand, Rhonda JV Montgomery, Ali Ahmadi, Linda Miller, Mike Mings and Nate Moore.

3

Funding Rounds

$20.7m

Money raised

DisruptOps made Cloud Detection and Response platform that automates assessment and remediation procedures of critical cloud security issues.

2

Funding Rounds

$67.0m

Money raised

Smith Electric Vehicles is a company manufacturing electric commercial trucks founded in 1920.

2

Funding Rounds

$5.2m

Money raised

Agragene develops sterile male insects to replace chemical pesticides for the control of crop pests

3

Funding Rounds

$48.9m

Money raised

PierianDx is a company that is enabling the global adoption of genomic sequencing in the healthcare industry.

6

Funding Rounds

$114.9m

Money raised

Developer of an AI-powered support automation platform intended to transform the modern workplace. The company's platform offers data integration with a cloud application, data mining, data capturing and provides unified and immediate access to anywhere in the database, enabling companies to access their information instantly and empowers teams to have instant access to the knowledge they need to do their best work.

6

Funding Rounds

$51.9m

Money raised

Balto is a real-time guidance platform that increases conversions and decreases ramp time for contact centers.

10

Funding Rounds

$141.1m

Money raised

A company that develops M-trophs to improve crops' nutrient uptake and strength, stability and stress tolerance

1

Funding Rounds

$1.4m

Money raised

Rebundle is a St. Lois-based startup developing hair extensions made from plant-based materials with the aim of eliminating extension-related skin rashes and single-use waste.

Location:

1

Funding Rounds

$6.0m

Money raised

Native Pet crafts organic supplements for dogs and cats that harness the nutritional power of whole food ingredients

Industries:

Location:

2

Funding Rounds

$6.8m

Money raised

LockerDome is an advertising platform founded in 2008 in St. Louis, Missouri, by CEO Gabe Lozano.

7

Funding Rounds

$24.5m

Money raised

Immunophotonics is a company developing immunotherapy-based treatments for cancer founded in 2012 by Lu Alleruzzo.

1

Funding Rounds

$1.1m

Money raised

EternoGen is a skin products company

3

Funding Rounds

$406.0m

Money raised

EquipmentShare is a company providing a peer-to-peer equipment rental marketplace and telematics and equipment utilization services.

2

Funding Rounds

$10.0m

Money raised

Handmark is a Kansas City, Missouri-based company founded in 2017.

1

Funding Rounds

$1.6m

Money raised

Well Principled provides artificial intelligence management solutions for retail and consumer packaged goods brands.

1

Funding Rounds

$1.0m

Money raised

Tallyfy is a company founded in 2015 by Amit Kothari.

1

Funding Rounds

$8.4m

Money raised

Jane.ai, formerly known as Ai Software, is an artificial intelligence company headquartered in St. Louis, Missouri.

4

Funding Rounds

$7.8m

Money raised

Canopy Biosciences is a company that aims to increase the commercialization of life science reagent tools and services via in-licensing key technologies.

3

Funding Rounds

$21.7m

Money raised

Label Insight is a SaaS company that provides insights on food label data to government, retailers, manufacturers and app developers.

1

Funding Rounds

Altimetrik is a Southfields-based company founded in 2012.

1

Funding Rounds

$1.3m

Money raised

Healium is a Columbia, Missouri-based augmented and virtual reality channel powered by consumer wearables for the self-management of anxiety.

4

Funding Rounds

$126.7m

Money raised

Geneoscopy, Inc. is a St. Louis-based developer of medical diagnostics systems including non-invasive cancer diagnostics from biomarkers.

3

Funding Rounds

$40.4m

Money raised

Developer of a cryptographic platform designed to share, leverage, and monetize regulated data.

1

Funding Rounds

$9.2m

Money raised

Baswood offers a range of industrial and municipal markets with technology solutions to treat wastewater and bio-solids

8

Funding Rounds

$49.3m

Money raised

ZAF Energy Systems is a company founded in 2011 by Craig Wilkins.

1

Funding Rounds

$172.0m

Money raised

Wugen is an off-the-shelf Cell Therapies for Cancer founded by Matthew Cooper, Todd Fehniger, Melissa Berrien-Elliott and John DiPersio.

6

Funding Rounds

$15.6m

Money raised

SentiAR is a company founded in 2017 by Jonathan Silva, Dr. Jennifer Silva, Jim Howard and Michael Southworth.

2

Funding Rounds

$640.0m

Money raised

TierPoint is a St. Louis-based company that provides companies with personalized IT solutions.

8

Funding Rounds

$25.5m

Money raised

Akermin, Inc. is a company founded in 2004 by Shelley Minteer.

2

Funding Rounds

$5.0m

Money raised

Aker Technologies is a company founded in 2016.

1

Funding Rounds

$500.0k

Money raised

DailyRounds is a flipboard + Clinical Cases Challenges for Doctors founded in 2014 by Nimmi Cherian.

1

Funding Rounds

$20.0m

Money raised

FinLocker is a consumer-enabled financial data platform that gives lenders access to critical borrower information via a trusted 3rd party that can be used to streamline the origination and underwriting processes for mortgages and other financial products. It reduces costs, time, and risks for all participants in the loan life-cycle, while expediting the data collection, verification, and analytics processes. The consumer can also use FinLocker to manage their personal finances. For more information, visit www.FinLocker.com

1

Funding Rounds

$16.6m

Money raised

CrossFirst Bank is a company founded in 2007.

1

Funding Rounds

$58.0m

Money raised

CIC has been a home for great entrepreneurs leading fast-growing companies since 1999.

3

Funding Rounds

$26.8m

Money raised

Mazen Animal Health Inc. is a company founded in 2016.

1

Funding Rounds

Smart Diagnostics Systems is a Jefferson City, Missouri-based biotechnology and diagnostics company developing diagnostics for the detection of dangerous microorganisms.

1

Funding Rounds

$160.0k

Money raised

Juristat is a St. Louis-based company founded in 2012 by Andrew Winship, Jordan Woerndle and Robert Ward.

1

Funding Rounds

$700.0k

Money raised

gremln is a company founded in 2011 by Ryan Bell.

1

Funding Rounds

$8.0m

Money raised

Developer of a real estate platform designed to ease the process of buying and selling properties. The company's platform connects sellers with local real estate agents who then list the seller's home for an affordable rate eliminating the need for an agent or intermediaries, enabling property owners to find top real estate agents and save time and money in the sale process.

3

Funding Rounds

$12.0m

Money raised

Beijing Sinogene Biotechnology Co. Ltd. is a Beijing-based biotechnology company founded in 2012 and specializes in animal gene technology, it is a company that specializes in cloning and cell preservation of horse and dog using genome editing.

1

Funding Rounds

CentralReach is the developer of a suite of software for the healthcare industry including practice management and appointment scheduling solutions.

1

Funding Rounds

$50.0k

Money raised

Rovertown is a company founded in 2009 by Mike Philip.

2

Funding Rounds

$7.5m

Money raised

Bandura provides network security solutions for automated protection against inbound attacks and outbound data loss.

4

Funding Rounds

$42.8m

Money raised

Summersalt is a company founded in 2017.

2

Funding Rounds

$16.9m

Money raised

Rollick is a Fenton, Missouri-based company founded in 2017.

1

Funding Rounds

$1.3m

Money raised

StoryUP creates data-driven VR escapes for areas of acute stress. Using BCI (brain computer interface), we also enable the user to control some experiences with their own brainwaves.

2

Funding Rounds

$750.0k

Money raised

Dropcopter is a company that automates seed planting and fruit pollination.

1

Funding Rounds

$3.0m

Money raised

Developer of a real estate transaction platform intended to streamline and add transparency to real estate transactions for home buyers and sellers nationwide. The company's platform offers tech-enabled transaction coordinators that coordinate the many tasks and moving parts that real estate professionals are responsible for during a real estate transaction, enabling brokers and agents to improve value-added service and generate more revenue.

Sign up to access our full database

Enter your email and get access to 71,000 + technology companies you can partner with.

Join 29000+ founders, operators, and investors.