69 Best Startups in Missouri to Watch in 2025

The Definitive Seedtable Ranking of Startups in Missouri

We track 71,000+ companies and rank them dynamically using our Seedtable Score – a score that uses quantitative and qualitative data points to signal the momentum behind a company. We then monitor the list manually leveraging our expertise as founders and investors.

There are 76 start-ups with an aggregate funding of $2.1b. The average funding per company in this subset is $30.2m.

Last update to the database: Feb 18, 2025. See changelog.

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1

Funding Rounds

$25.0m

Money raised

Hungry Planet is a food technology startup company founded in 2016 by siblings Todd and Jody Boyman. Hungry Planet is located in St.Louis, Missouri, and produces plant-based meats. The company offers beef, Italian sausage, chorizo, chicken, pork, crab and turkey - available in chubs (ground), crumble and patties.

Key people:

6

Funding Rounds

$46.0m

Money raised

A company using RNA to diagnose disease and to develop biomarkers that predict treatment outcomes. Cofactor is founded by Jarret Glasscock.

Key people:

2

Funding Rounds

$20.0m

Money raised

Zeno Power Systems is an Arlington, Virginia-based developer of a radioisotope power system intended to convert heat from recycled nuclear waste into electricity.

5

Funding Rounds

$65.4m

Money raised

An agricultural biotechnology company producing renewable, biomass-based fuels and raw materials

5

Funding Rounds

$67.5m

Money raised

A health care provider in Missouri that focuses on continuous primary care online.

Key people:

9

Funding Rounds

$81.0m

Money raised

A medical diagnostics company that develops biological assay platform for measuring clinical and point-of-care samples

8

Funding Rounds

$20.9m

Money raised

TCARE is a software platform for preventing burnout for caregivers founded in 2014 by Vijay Anand, Rhonda JV Montgomery, Ali Ahmadi, Linda Miller, Mike Mings and Nate Moore.

2

Funding Rounds

$5.2m

Money raised

Agragene develops sterile male insects to replace chemical pesticides for the control of crop pests

Key people:

3

Funding Rounds

$48.9m

Money raised

PierianDx is a company that is enabling the global adoption of genomic sequencing in the healthcare industry.

Location:

Key people:

6

Funding Rounds

$114.9m

Money raised

Developer of an AI-powered support automation platform intended to transform the modern workplace. The company's platform offers data integration with a cloud application, data mining, data capturing and provides unified and immediate access to anywhere in the database, enabling companies to access their information instantly and empowers teams to have instant access to the knowledge they need to do their best work.

6

Funding Rounds

$51.9m

Money raised

Balto is a real-time guidance platform that increases conversions and decreases ramp time for contact centers.

Location:

Key people:

10

Funding Rounds

$141.1m

Money raised

A company that develops M-trophs to improve crops' nutrient uptake and strength, stability and stress tolerance

Key people:

7

Funding Rounds

$24.5m

Money raised

Immunophotonics is a company developing immunotherapy-based treatments for cancer founded in 2012 by Lu Alleruzzo.

Key people:

1

Funding Rounds

$60.0m

Money raised

Key people:

1

Funding Rounds

$1.0m

Money raised

Tallyfy is a company founded in 2015 by Amit Kothari.

Key people:

1

Funding Rounds

$1.3m

Money raised

Healium is a Columbia, Missouri-based augmented and virtual reality channel powered by consumer wearables for the self-management of anxiety.

6

Funding Rounds

$15.6m

Money raised

SentiAR is a company founded in 2017 by Jonathan Silva, Dr. Jennifer Silva, Jim Howard and Michael Southworth.

Location:

Key people:

2

Funding Rounds

$640.0m

Money raised

TierPoint is a St. Louis-based company that provides companies with personalized IT solutions.

8

Funding Rounds

$25.5m

Money raised

Akermin, Inc. is a company founded in 2004 by Shelley Minteer.

Key people:

1

Funding Rounds

$20.0m

Money raised

FinLocker is a consumer-enabled financial data platform that gives lenders access to critical borrower information via a trusted 3rd party that can be used to streamline the origination and underwriting processes for mortgages and other financial products. It reduces costs, time, and risks for all participants in the loan life-cycle, while expediting the data collection, verification, and analytics processes. The consumer can also use FinLocker to manage their personal finances. For more information, visit www.FinLocker.com

1

Funding Rounds

$58.0m

Money raised

CIC has been a home for great entrepreneurs leading fast-growing companies since 1999.

3

Funding Rounds

$26.8m

Money raised

Mazen Animal Health Inc. is a company founded in 2016.

1

Funding Rounds

$700.0k

Money raised

gremln is a company founded in 2011 by Ryan Bell.

1

Funding Rounds

$50.0k

Money raised

Rovertown is a company founded in 2009 by Mike Philip.

4

Funding Rounds

$42.8m

Money raised

Summersalt is a company founded in 2017.

2

Funding Rounds

$6.1m

Money raised

Pluton Biosciences is a St. Louis-based developer of biomining processes.

1

Funding Rounds

APT Therapeutics is a company founded in 2002.

1

Funding Rounds

$11.5m

Money raised

Coolfire Solutions is a company founded in 2010 by Aditya Nishtala.

1

Funding Rounds

$6.0m

Money raised

Bacterioscan is a St. Louis-based infectious disease diagnostics company.

2

Funding Rounds

$1.3m

Money raised

NeuroLutions is a device for Stroke Recovery founded in 2007 by Daniel Moran.

2

Funding Rounds

$11.6m

Money raised

OPER is a company founded in 2018.

Location:

1

Funding Rounds

$4.7m

Money raised

Oncodesign is a preclinical services founded in 1995.

3

Funding Rounds

$2.2m

Money raised

Bonfyre is a Missouri-based human resources company founded in 2012.

Industries:

Location:

1

Funding Rounds

A company developing inhibitors for the treatment of cancer

1

Funding Rounds

$3.0m

Money raised

Q-Net Security is a St. Louis, Missouri-based company which makes and distributes endpoint security hardware and software to clients with high security needs.

2

Funding Rounds

$4.1m

Money raised

A company dedicated to drug designs to develop kinase inhibitors for healthcare of human and animals

Location:

1

Funding Rounds

Sequoia Sciences is a company founded in 2012 by Gary Eldridge.

2

Funding Rounds

A company developing and providing products and services in the field of biologics development and functional proteomics

4

Funding Rounds

$8.5m

Money raised

Atomation is an edge computing company using data to develop actionable information.

1

Funding Rounds

$2.6m

Money raised

myEDmatch is a Missouri-based company founded in 2012 by Munro Richardson.

Location:

Key people:

1

Funding Rounds

$50.0k

Money raised

Dead Inventory Management System is a company founded in 2011.

Location:

1

Funding Rounds

$3.5m

Money raised

Ryvit is a company founded in 2014 by Tom Stemm.

1

Funding Rounds

$1.1m

Money raised

SwipeSum is a company founded in 2016 by Michael Seaman.

Location:

Key people:

1

Funding Rounds

$50.0k

Money raised

Time to Cater is a catering company.

Industries:

Location:

1

Funding Rounds

$200.0k

Money raised

MarketRiders is a company founded by Ryan Pfenninger.

1

Funding Rounds

$3.1m

Money raised

SchoolTube is a Missouri-based company founded in 2007 by Andrew A Arizpe.

1

Funding Rounds

$31.0m

Money raised

Veran Medical Technologies is a thoracic Navigation System.

1

Funding Rounds

$10.0m

Money raised

Exegy is a Missouri-based company founded in 2003.

Location:

1

Funding Rounds

$2.5m

Money raised

Signature Medical is a Missouri-based healthcare company founded in 2001.

Industries:

Location:

1

Funding Rounds

$500.0k

Money raised

Precision Virologics is a Missouri-based company founded in 2016 by David T. Curiel.

Location:

Key people:

1

Funding Rounds

$835.0k

Money raised

Graematter is a company founded in 2000.

Location:

1

Funding Rounds

$10.0m

Money raised

VelociData, Inc. is a company founded in 2012.

Location:

1

Funding Rounds

$1.8m

Money raised

Innovectra is an advertising company.

Industries:

Location:

2

Funding Rounds

$14.2m

Money raised

TCare, Inc. is a Missouri-based company founded in 2017.

Location:

1

Funding Rounds

$2.5m

Money raised

Roof4All MCI 1, LLC is a Missouri-based company founded in 2019.

Location:

1

Funding Rounds

$7.5m

Money raised

Finnovant Inc. is a company founded in 2020.

1

Funding Rounds

$10.0m

Money raised

Location:

1

Funding Rounds

$6.6m

Money raised

Nous Imaging, Inc. is a Missouri-based company.

Location:

1

Funding Rounds

$5.0m

Money raised

NP Fund IV Blocker, Inc. is a company founded in 2019.

1

Funding Rounds

$3.4m

Money raised

Advocado, Inc. is a Missouri-based advertising company.

Industries:

Location:

1

Funding Rounds

$18.0m

Money raised

Blackmore Sensors is a Missouri-based company.

Industries:

Location:

1

Funding Rounds

$16.4m

Money raised

United Group of Investors, LLC is a company founded in 2018.

Location:

1

Funding Rounds

$1.4m

Money raised

eHawk, Inc. is a Missouri-based company.

Location:

1

Funding Rounds

$250.0k

Money raised

Darby Rose Princeton Parc, LLC is a Missouri-based company founded in 2019.

Location:

1

Funding Rounds

$2.0m

Money raised

O Fallon Square, LLC is a Missouri-based company founded in 2019.

Location:

1

Funding Rounds

$10.0m

Money raised

YWHALES LLC is a Missouri-based company founded in 2022.

Location:

1

Funding Rounds

$250.0m

Money raised

Alternative Platform LLC is a Missouri-based company founded in 2020.

Location:

1

Funding Rounds

$500.0k

Money raised

4ME4WE LLC is a Missouri-based company.

Location:

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