54 Best Startups in Chicago United States to Watch in 2025

The Definitive Seedtable Ranking of Startups in Chicago United States

We track 71,000+ companies and rank them dynamically using our Seedtable Score – a score that uses quantitative and qualitative data points to signal the momentum behind a company. We then monitor the list manually leveraging our expertise as founders and investors.

There are 3,102 start-ups with an aggregate funding of $27.0b. The average funding per company in this subset is $499.4m.

Last update to the database: Feb 18, 2025. See changelog.

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1

Funding Rounds

$1.5m

Money raised

Developer of low-latency and high-throughput broadband networks for AR/VR, IoT, robotics, and other emerging technologies.

5

Funding Rounds

$5.0b

Money raised

AI safety and research platform.

Key people:

6

Funding Rounds

$799.8m

Money raised

A bank offering online banking services with no user no bank fees, and an option to receive direct deposit up to two days early. Chris Britt and Ryan King founded Chime in 2013, and the company is headquartered in San Francisco, California.

1

Funding Rounds

$35.0m

Money raised

Fractal is a gaming marketplace developed to facilitate non-fungible tokens (NFTs).

3

Funding Rounds

$17.5m

Money raised

Numerai is a hedge fund with stock market trades determined by crowdsourced artificial intelligence models. The best models receive rewards in the form of a cryptographic token called Numeraire (NMR) on the Ethereum blockchain.

2

Funding Rounds

$27.0m

Money raised

CryptoKitties is a game built on the Ethereum blockchain in which users can collect and trade virtual kittens.

1

Funding Rounds

$510.0k

Money raised

Wavel.ai is a voice AI solution for scaling and localizing video content.

4

Funding Rounds

$583.6m

Money raised

TriNet Zenefits is a software as a service (SaaS) company providing a digital human resources platform for small- and medium-sized enterprises (SMEs).

5

Funding Rounds

$72.2m

Money raised

Arzeda is a biotechnology and software company designing custom microorganisms for industrial applications through computational enzyme design, protein optimization, and metabolic engineering.

Key people:

6

Funding Rounds

$292.4m

Money raised

Calm is a health technology start-up based in San Francisco. It was founded in 2012 by Alex Tew and Michael Acton Smith and produces a mobile application for sleep, relaxation, and meditation.

8

Funding Rounds

$406.4m

Money raised

Bolt Threads is a biotechnology company that makes high performance fabrics and materials using biology.

5

Funding Rounds

$349.2m

Money raised

HashiCorp is a software company providing tools for developers and security professionals to provision, secure, and run infrastructure for distributed applications for organizations.

Key people:

7

Funding Rounds

$165.1m

Money raised

Figment is a blockchain infrastructure and software provider.

Location:

Key people:

2

Funding Rounds

$29.5m

Money raised

Immunefi is a bug bounty security services platform that focuses on bug bounty and security services for Web3 projects.

Key people:

3

Funding Rounds

$54.2m

Money raised

Layer1 is a cryptocurrency investment and infrastructure platform.

3

Funding Rounds

$764.7m

Money raised

Bitmain is a Beijing-based multinational semiconductor company, founded in 2013, that manufactures products for blockchain and artificial intelligence (AI) applications.

3

Funding Rounds

$2.3m

Money raised

A web and API platform that provides Bitcoin and Altcoin conversion.

7

Funding Rounds

$711.5m

Money raised

Perfect Day Foods (formerly Muufri) engineered yeast capable of producing the proteins found in cows milk. They use these proteins to make their own line of animal-free dairy products.

Key people:

7

Funding Rounds

$81.3m

Money raised

Kepler Communications is a company that has a focus on satellite production and communication networks.

6

Funding Rounds

$97.8m

Money raised

Mighty Buildings is a company working in the construction industry with 3D printing technology and advanced composite materials, funded by Y Combinator.

10

Funding Rounds

$1.0b

Money raised

DataRobot sells a machine learning platform that helps users build and deploy accurate predictive models. The Boston-based company was founded in 2012 by Jeremy Achin.

8

Funding Rounds

$390.0m

Money raised

Exabeam is a San Mateo, California-based data security analytics company offering cybersecurity and early cyber attack detection software.

5

Funding Rounds

$390.0m

Money raised

PathAI is a Boston-based artificial intelligence company developing therapeutics and healthcare products.

1

Funding Rounds

$6.0m

Money raised

Maximum protection and yield, fully protected through Protocol Controlled Underwriting.

1

Funding Rounds

$50.0k

Money raised

HYPRES is a developer of superconducting microelectronics for defense, wireless, and optical network industries.

6

Funding Rounds

$100.9m

Money raised

AppZen is a San Jose, California-based company that provides an AI-based auditing platform for finance teams.

Key people:

10

Funding Rounds

$930.0m

Money raised

Tempus, a technology company advancing precision medicine through the practical application of artificial intelligence in healthcare.

2

Funding Rounds

Hypergiant Industries is a machine learning and artificial intelligence company offering client-focused services and research and development in various fields. The company was founded by Ben Lamm and John Fremont in 2018.

6

Funding Rounds

$898.4m

Money raised

Wise, previously TransferWise, is a company that offers money transfers services founded by Kristo Käärmann and Taavet Hinrikus.

8

Funding Rounds

$646.9m

Money raised

Socure is a New York City-based developer of an identity verification and fraud risk solution.

1

Funding Rounds

$3.3m

Money raised

ItBit is a platform for institutions and active investors to trade cryptocurrency assets.

8

Funding Rounds

$551.0m

Money raised

Eat Just is a San Francisco based food technology company founded in 2011. The company is known for its bean-based egg substitute called Just Egg. Eat Just also produces egg-free mayonnaise.

4

Funding Rounds

$1.8b

Money raised

Grail is a biotechnology company headquartered in Menlo Park, California that was founded as a spinoff of Illumina Inc and initially headed by Jeffrey Huber in 2016, focused on making a medical device that can detect early stage cancer.

2

Funding Rounds

$7.0m

Money raised

P2E game build on Solana blockchain. Grab your mask and start your journey - level up from card strategy battle game to full MMO glory!

21

Funding Rounds

$1.9b

Money raised

Apeel Sciences is a company that develops treatments to prevent spoilage of fruits and vegetables using molecules naturally found in peels, which maintain moisture and keep out oxygen.

3

Funding Rounds

$22.8m

Money raised

Distil Networks was an American cybersecurity company founded in 2011 and headquartered in San Francisco, California.

4

Funding Rounds

$477.4m

Money raised

Grove Collaborative is an online, subscription-based retailer selling natural home and health products.

Key people:

2

Funding Rounds

$37.0m

Money raised

Blue Hexagon is a San Francisco-based cybersecurity company offering an on-device machine learning based malware detection product.

Key people:

2

Funding Rounds

$2.0b

Money raised

Razer is a United States-based company founded in 2005 by Min-Liang Tan.

Location:

Key people:

5

Funding Rounds

$40.0m

Money raised

Enveil is a Fulton, Maryland-based data security and privacy security technology company.

9

Funding Rounds

$378.4m

Money raised

Bitso is a cryptocurrency exchange for buying and selling Bitcoin, Ethereum, Litecoin, Bitcoin Cash, TrueUSD, Decentraland, Golem, and Basic Attention Token.

5

Funding Rounds

$2.1b

Money raised

Commonwealth Fusion Systems is a Cambridge, Massachusetts-based research and development company developing fusion power systems based on ARC tokamak reactors.

6

Funding Rounds

$200.0m

Money raised

A software company making a workplace email communication platform for remote and office work.

Key people:

7

Funding Rounds

$66.0m

Money raised

Superplastic is a creative product and experience studio founded in 2018.

Key people:

22

Funding Rounds

$1.4b

Money raised

BlockFi is a blockchain platform for high-interest crypto accounts and low-cost credit products.

Key people:

3

Funding Rounds

$125.0m

Money raised

Synchron, Inc. is a technology company building implantable neural interface solutions, including endovascular brain-computer interface.

9

Funding Rounds

$899.3m

Money raised

Arctic Wolf Networks provides a cybersecurity platform that executes risk management and task analysis using machine learning.

8

Funding Rounds

$71.3m

Money raised

Notable Labs is a company providing personalized drug combination testing service for cancer patients.

9

Funding Rounds

$276.0m

Money raised

A diagnostic DNA testing company using quantified biological data.

4

Funding Rounds

$295.0m

Money raised

Califia Farms makes plant-based dairy products (primarily almond based) such as plant-based milks, plant-based creamers, juices, and dairy-free probiotic yoghurts. The company was founded in 2010 by Greg Steltenpohl and is located in San Joaquin Valley, California.

2

Funding Rounds

$14.6m

Money raised

A biotechnology company that has built a robotic cloud lab which allows on-demand services for biology laboratories.

Key people:

7

Funding Rounds

$314.2m

Money raised

HawkEye 360 is a Herndon, Virginia-based data analytics company developing radio frequency mapping technologies for use in space.

Key people:

4

Funding Rounds

$126.0m

Money raised

Mercury is a company making banking products for startups based in San Francisco and backed by a16z.

Key people:

3

Funding Rounds

$14.3m

Money raised

Aria Pharmaceuticals is a first-in-class pharmaceutical discovery and development founded in 2014 by Andrew M. Radin.

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