69 Best Startups in Baltimore to Watch in 2025

The Definitive Seedtable Ranking of Startups in Baltimore

We track 71,000+ companies and rank them dynamically using our Seedtable Score – a score that uses quantitative and qualitative data points to signal the momentum behind a company. We then monitor the list manually leveraging our expertise as founders and investors.

There are 143 start-ups with an aggregate funding of $2.7b. The average funding per company in this subset is $39.1m.

Last update to the database: Feb 18, 2025. See changelog.

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6

Funding Rounds

$356.3m

Money raised

Insilico Medicine is a drug discovery, artificial intelligence company that looks to treat cancer and age related diseases

5

Funding Rounds

$2.3m

Money raised

An app that aggregates social media data to produce a real-time map of sickness.

1

Funding Rounds

$3.7m

Money raised

Dispatch Goods excludes disposable foodware from food delivery by coordinating into food delivery apps.

1

Funding Rounds

$2.0m

Money raised

A biotechnology company founded in 2006 and based in Baltimore, MD, that develops polymers to deliver DNA and RNA therapeutics.

7

Funding Rounds

$52.4m

Money raised

Protenus is a company that participated in the DreamIT Ventures - Health Baltimore 1/1/14 cohort .

5

Funding Rounds

$153.5m

Money raised

ZeroFOX is a digital Risk Protection Platform founded in 2013 by James Foster, Robert Francis, Evan Blair, Chris Cullison and Hillary Herlehy.

5

Funding Rounds

$127.6m

Money raised

Omniome is a San Diego-based company.

2

Funding Rounds

$40.0m

Money raised

AsclepiX Therapeutics is a Baltimore-based biotechnology company developing therapeutics for the treatment of retinal diseases and cancer.

2

Funding Rounds

$7.2m

Money raised

emocha Mobile Health is a company founded in 2008 by Jeff Daley, Morad Elmi, Sharon Kong, Sebastian Seiguer and Gorkem Sevinc.

12

Funding Rounds

$479.3m

Money raised

Personal Genomics is a medical diagnostics company developing tissue-based and liquid biopsy genomic products for laboratory and diagnostic applications.

3

Funding Rounds

$13.9m

Money raised

Elixirgen Therapeutics is a Baltimore-based biotechnology company.

3

Funding Rounds

$326.1m

Money raised

Delfi Diagnostics is a Baltimore, Maryland based company whose mission is to develop a blood test for cancer detection

1

Funding Rounds

$5.0m

Money raised

WindMIL Therapeutics is a biotechnology company developing cell therapy products for treating cancer.

4

Funding Rounds

$183.0m

Money raised

Facet Wealth provides full financial life management, delivered by a dedicated team led by a CFP Professional, to mass affluent households. We also work with financial services professionals as a solution for small accounts.

2

Funding Rounds

$17.0m

Money raised

Sonavex is a developer of an imaging technology designed to visualize and quantify critical data to detect anastomotic blood clots.

Key people:

2

Funding Rounds

$164.0m

Money raised

Operator of an online eCommerce platform designed to sell direct-to-consumer products.

2

Funding Rounds

$4.7m

Money raised

Parking Panda is a company founded in 2011 by Nick Miller.

2

Funding Rounds

$14.0m

Money raised

Insightin Health is a Baltimore-based company founded in 2016.

2

Funding Rounds

$38.0m

Money raised

Whitebox offers sales and fullfillment solutions for brands and manufacturers

3

Funding Rounds

$5.5m

Money raised

Rose Health is a mental health technology company.

4

Funding Rounds

$34.9m

Money raised

A company developing therapies for cancer and immune disorders

8

Funding Rounds

$2.2m

Money raised

Blue Wave Semiconductors is a company that manufactures thin film deposition equipment.

Industries:

Location:

2

Funding Rounds

Fyodor Biotechnologies is a Baltimore-based medical device company offering diagnostic tools.

3

Funding Rounds

$31.2m

Money raised

Catalyte is an artificial Intelligence company founded in 2000.

4

Funding Rounds

$3.0m

Money raised

NextStep Robotics is a Baltimore-based company founded in 2017 by Bradley Hennessie.

Location:

Key people:

1

Funding Rounds

Privva is a cloud-based vendor risk assessment platform with offices in both Baltimore, Maryland and Arlington, Virginia. It was founded in 2016 by Ishan Girdhar and John Lemp.

2

Funding Rounds

$6.5m

Money raised

Osmosis is a company founded in 2015 by Shiv Gaglani.

1

Funding Rounds

$10.0m

Money raised

StraighterLine is a Baltimore-based company founded in 2008.

1

Funding Rounds

$1.2m

Money raised

Sisu Global Health is a Baltimore-based company founded in 2014 by Katherine Kirsch, Carolyn Yarina and Gillian Henker.

4

Funding Rounds

$1.8m

Money raised

RedShred is an artificial Intelligence company founded by Jeehye Yun.

3

Funding Rounds

$7.5m

Money raised

Sonavi Labs is a medical device company founded in 2017.

2

Funding Rounds

$2.5m

Money raised

SocialToaster is a Baltimore-based company founded in 2010 by Brian Razzaque.

1

Funding Rounds

$850.0k

Money raised

Citelighter is a Baltimore-based company founded in 2011 by Saad Alam.

Location:

Key people:

4

Funding Rounds

$70.8m

Money raised

Social Solutions is a Baltimore-based company founded in 2018.

1

Funding Rounds

$18.0m

Money raised

Huntress provides managed threat detection and response services to uncover and address malicious footholds that slip past your preventive defenses.

1

Funding Rounds

Noxilizer is a Hanover, Maryland-based company providing ultra-low temperature nitrogen dioxide sterilization technology and equipment to pharmaceutical, biotech, and medical device manufacturers.

4

Funding Rounds

$5.9m

Money raised

Manufacturer of laundry detergent designed to clean and protect activewear and synthetic-based materials. The company's detergent gets deep into tight-knit fabrics to remove odors and stains left behind by the bacteria that traditional detergents can't reach, enabling customers to keep their activewear soft and preserve their stretch, color.

1

Funding Rounds

$4.0m

Money raised

Allovue is a company founded in 2013 by Jess Gartner.

3

Funding Rounds

$9.3m

Money raised

BurnAlong is a company founded by Daniel Freedman.

2

Funding Rounds

$30.5m

Money raised

CSA Medical is a spray Cryotherapy founded in 2005.

1

Funding Rounds

$5.0m

Money raised

CDI Laboratories is a company focused on research and development in proteomics.

2

Funding Rounds

$2.0m

Money raised

Protego Labs, Inc. is a company that develops security services for providing security to serverless applications.

3

Funding Rounds

$36.9m

Money raised

Oculis Labs is a company founded in 2017.

Location:

1

Funding Rounds

$750.0k

Money raised

Mailstrom is a Baltimore-based productivity software company founded in 2010.

Industries:

Location:

3

Funding Rounds

$41.5m

Money raised

Developer of synthetic soft tissue substitutes intended to be used for aesthetic and reconstructive medicine in tissue reproduction.

1

Funding Rounds

$12.0m

Money raised

Traitify is a company founded in 2011.

3

Funding Rounds

$28.0m

Money raised

Pixelligent is a Baltimore-based company founded in 2009.

3

Funding Rounds

$42.7m

Money raised

Apkudo is a Baltimore-based company founded in 2011 by Benno Leslie.

4

Funding Rounds

$58.9m

Money raised

WhyHotel is an alternative lodging service that operates pop-up hotels in newly built, luxury apartment buildings.

2

Funding Rounds

$7.0m

Money raised

VerImmune is an Immuno-Oncology company developing a first-in-class cancer therapy known as Anti-tumor Immune Redirection.

1

Funding Rounds

$5.0m

Money raised

FactoryFour is a company founded in 2015.

1

Funding Rounds

Pinkaloo Technologies is a charitable giving platform designed to add transparency to where an individual's donation dollars go to in a charity. It was founded in 2016.

Industries:

Location:

1

Funding Rounds

$1.0m

Money raised

Yet Analytics is a Baltimore-based company founded in 2014.

Location:

2

Funding Rounds

$3.0m

Money raised

Vixiar Medical develops non-invasive, cost-effective devices and systems for monitoring cardiopulmonary diseases.

2

Funding Rounds

$20.2m

Money raised

A medical technology company treating migraine with transcranial magnetic stimulation devices

1

Funding Rounds

$3.4m

Money raised

Ryse Health is a healthcare company founded in 2021 by Richard Gurley.

2

Funding Rounds

$8.0m

Money raised

A company developing preventive and therapeutic vaccines for infectious diseases and oncolytic vaccines for cancer

Location:

Key people:

1

Funding Rounds

$100.0k

Money raised

Dynamhex is a personalized, localized, and standardized climate action platform.

4

Funding Rounds

$64.8m

Money raised

One by AOL is a Baltimore-based company founded in 1996.

Location:

3

Funding Rounds

$9.8m

Money raised

Cerebro Capital is a Baltimore-based financial services company founded in 2017.

Industries:

Location:

4

Funding Rounds

$5.8m

Money raised

PathoVax is an HPV vaccine founded in 2014 by Joshua Wang.

2

Funding Rounds

$4.0m

Money raised

EcoMap Technologies, Inc. is a Baltimore-based company founded in 2018 by Pava LaPere.

Location:

Key people:

2

Funding Rounds

$21.0m

Money raised

Hungry Harvest is a food company founded in 2014 by Evan Lutz.

Key people:

1

Funding Rounds

$20.5m

Money raised

Glyscend Incorporated is a Non-Invasive Bariatric Bypass Technology founded in 2014.

1

Funding Rounds

$900.0k

Money raised

DinnerTime is a Baltimore-based cooking company founded by Charles P. Moore, Laura Moore, Sharon Lacy and Doug Lay.

2

Funding Rounds

$44.0m

Money raised

Vita Therapeutics is a company founded in 2018.

1

Funding Rounds

$6.0m

Money raised

By offering continuous, proactive monitoring of critical data and rapid breach detection, we enable companies to better manage risk and keep high-value data safe.

1

Funding Rounds

$6.4m

Money raised

Sunairio is a developer of a weather intelligence platform for renewable energy prediction.

Location:

Key people:

1

Funding Rounds

$5.0m

Money raised

Clean.io, Inc. is a Baltimore-based it consulting company founded in 2019.

Industries:

Location:

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