69 Best Startups in Indianapolis to Watch in 2025

The Definitive Seedtable Ranking of Startups in Indianapolis

We track 71,000+ companies and rank them dynamically using our Seedtable Score – a score that uses quantitative and qualitative data points to signal the momentum behind a company. We then monitor the list manually leveraging our expertise as founders and investors.

There are 153 start-ups with an aggregate funding of $1.6b. The average funding per company in this subset is $23.0m.

Last update to the database: Feb 18, 2025. See changelog.

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3

Funding Rounds

$21.0m

Money raised

Kite.Com is a San Francisco-based company that builds AI-powered auto-complete features for developers.

1

Funding Rounds

Doxim is a Markham, Ontario-based customer communications and engagement technology software development company focused on providing omnichannel communications and payment solutions for the financial services industry.

2

Funding Rounds

$765.0k

Money raised

Obie was an AI agent that could answer frequently asked questions by accessing tools like Confluence, Google Drive, Jira, Dropbox, etc.

3

Funding Rounds

$45.1m

Money raised

Encamp is a technology company offering environmental compliance programs.

1

Funding Rounds

$300.0k

Money raised

Xylogenics is a biofuels production company that uses yeast genomics founded in 2008 by Joshua Heyen.

9

Funding Rounds

$130.5m

Money raised

Scale Computing is a software company focusing IT infrastructure products.

1

Funding Rounds

$2.0m

Money raised

Canopy is a revenue intelligence software company.

1

Funding Rounds

$30.0m

Money raised

Lev is a company founded in 2006 by Geoffrey Mobisson.

3

Funding Rounds

$2.8m

Money raised

Docket is a meeting-focused workspace for collaborative agenda creation, decision documentation, and action item tracking.

5

Funding Rounds

$40.0m

Money raised

Springbuk is a Health Intelligence platform that delivers intelligent, actionable strategies, backed by data, empowering employers and consultants to make smarter health management decisions.

3

Funding Rounds

$11.2m

Money raised

Medical Devices Prototyping, Engineering & Design; Biotech Consumables

1

Funding Rounds

$14.5m

Money raised

Aprimo is a company founded in 1998.

2

Funding Rounds

$10.0m

Money raised

PERQ, a marketing technology company, empowers businesses with more visibility into their digital marketing efforts and sales.

Location:

3

Funding Rounds

$119.0m

Money raised

JupiterOne is a security and compliance software developer and was developed by LifeOmic, a precision health software company.

1

Funding Rounds

$425.0m

Money raised

Formstack is a workplace productivity platform helps organizations digitize, automate workflows, and fix processes—all without code.

6

Funding Rounds

$39.4m

Money raised

Vibenomics powers audio out-of-home advertising and experiences for brands and location-based organizations.

3

Funding Rounds

$9.1m

Money raised

Octiv is an Indianapolis-based company founded in 2010.

5

Funding Rounds

$2.8m

Money raised

Perceivant is an Indianapolis-based company offering evidence-based monitoring and real-time tracking and analytics solutions.

4

Funding Rounds

$57.6m

Money raised

Zylo is an Indianapolis-based company founded in 2016.

4

Funding Rounds

$5.1m

Money raised

PAXAFE provides predictive analytics for the supply chain industry.

3

Funding Rounds

$24.9m

Money raised

Manufacturer of innovative medicines and devices for comprehensive eye care.

Location:

3

Funding Rounds

$19.8m

Money raised

Kenzie Academy is an online and campus-based higher education institution offering education for the technology and software sector.

1

Funding Rounds

$20.0m

Money raised

Intelinair is a company founded in 2015.

2

Funding Rounds

$8.3m

Money raised

A company developing and supplying biomaterial and cell cryopreservation systems and solutions to the healthcare industry

1

Funding Rounds

$6.5m

Money raised

In 2011, hc1 Insights™ (hc1) was created because our founder recognized that if labs could organize the vast amounts of powerful data they produce into actionable insights, they could be empowered to better manage operations, as well as personalize and advance care for all patients.

6

Funding Rounds

$13.7m

Money raised

PactSafe is an Indianapolis-based company founded in 2013 by Brian Powers, Eric Prugh and Adam Gillaspie.

3

Funding Rounds

$45.0m

Money raised

Learning management system for employees.

2

Funding Rounds

$3.1m

Money raised

Costello is an Indianapolis-based company founded in 2016 by Rod Feuer.

3

Funding Rounds

$3.6m

Money raised

Stamus Networks offers Scirius Security Platform solutions that marry real-time network traffic data with enhanced Suricata intrusion detection (IDS) and an advanced analytics engine.

1

Funding Rounds

$1.8m

Money raised

Scioto Biosciences Inc. focuses on delivery of microbiome therapeutics.

1

Funding Rounds

$400.0k

Money raised

NERx Biosciences focuses on small molecule cancer drugs.

2

Funding Rounds

$22.5m

Money raised

Emplify is a company founded in 2016.

3

Funding Rounds

$11.5m

Money raised

Trava simplifies cyber risk management for business owners and IT professionals.

6

Funding Rounds

$4.6m

Money raised

Driven Data Technology Inc. is an Indianapolis-based company offering a customer data platform for the automotive industry.

Location:

3

Funding Rounds

$10.5m

Money raised

Upper Hand is an Indianapolis-based company founded in 2015.

2

Funding Rounds

$25.0m

Money raised

Nico is a brain surgery technology founded in 2007.

2

Funding Rounds

$14.6m

Money raised

Viral Launch is an Indianapolis-based company.

Industries:

Location:

2

Funding Rounds

$13.6m

Money raised

DemandJump is an Indianapolis-based developer of customer relationship management software.

2

Funding Rounds

$2.9m

Money raised

ConverSight.ai is an Indianapolis-based company founded in 2017 by Ganesh Gandhieswaran.

3

Funding Rounds

$26.6m

Money raised

Developer of a business outcome management platform designed to offer real-time visibility into customer success.

Location:

1

Funding Rounds

Aptean provides industry-focused mission critical enterprise software solutions.

2

Funding Rounds

$2.8m

Money raised

250ok is an Indianapolis-based company founded in 2012.

Industries:

Location:

1

Funding Rounds

$14.0m

Money raised

Spiras Health is a healthcare company.

1

Funding Rounds

$4.0m

Money raised

ScanCafe is a company founded in 2006.

Location:

9

Funding Rounds

$40.3m

Money raised

Vibenomics, Inc. is a company founded in 2016.

2

Funding Rounds

$16.6m

Money raised

Epogee is an Indianapolis-based producer of a portfolio of fat replacement and flavor enhancement food ingredients.

1

Funding Rounds

$7.0m

Money raised

Blue Pillar is an Indianapolis-based company founded in 2006 by Walter (Larry) Orwin.

Industries:

Location:

1

Funding Rounds

$300.0k

Money raised

A biotechnology company developing immune tolerance therapies products for the treatment of autoimmune diseases in the lung

1

Funding Rounds

$13.0m

Money raised

Smarterhq is a multichannel Behavioral Marketing Platform founded in 2010.

3

Funding Rounds

$41.0m

Money raised

Sharpen Technologies is an Indianapolis-based company founded in 2011.

2

Funding Rounds

$5.0m

Money raised

Torchlite is an Indianapolis-based company founded in 2015.

2

Funding Rounds

$7.7m

Money raised

A pharmacy that offers techonology-enabled dispensing to deliver pharmacy services

1

Funding Rounds

$7.5m

Money raised

Biosynthetic Technologies is a biorefinery company that produces synthetic oils from organic fatty acids found in plant oils.

Industries:

Location:

2

Funding Rounds

$6.1m

Money raised

Bluelock is an Indianapolis-based company founded in 2010.

3

Funding Rounds

$12.0m

Money raised

Sigstr is an Indianapolis-based company founded in 2015.

8

Funding Rounds

$16.4m

Money raised

BidPal, Inc. is an Indianapolis-based company founded in 2011.

Location:

1

Funding Rounds

$30.0m

Money raised

Strand Diagnostics is a forensic and medical testing services company.

1

Funding Rounds

$6.0m

Money raised

Socio Labs is an Indianapolis-based company.

2

Funding Rounds

$13.3m

Money raised

Castiron, Inc. is an Indianapolis-based company founded in 2020.

Location:

1

Funding Rounds

$25.0m

Money raised

Kerauno is an Indianapolis-based company founded in 2018.

1

Funding Rounds

$500.0k

Money raised

Tudr Media is an Indianapolis-based company founded in 2017.

Location:

1

Funding Rounds

$1.0m

Money raised

Emerging Threats is an Indianapolis-based security company founded in 2003.

Industries:

Location:

2

Funding Rounds

$1.3m

Money raised

Compact Medical Solutions is focused on making the world's smallest, fully-functional resuscitator to ensure that lifesaving equipment is always available when needs arise.

Location:

1

Funding Rounds

$5.0m

Money raised

Market Wagon is a company founded in 2017.

1

Funding Rounds

$6.0m

Money raised

Socio is an event management founded in 2016 by Yarkin Sakucoglu, Joseph Watkins and Alihan Ozbayrak.

1

Funding Rounds

POLARIS Laboratories is an oil & energy company that offers oil and coolant testing services.

1

Funding Rounds

$250.0k

Money raised

Highfive Focusing on the needs of all students and educators to help build compassion.

Location:

Key people:

1

Funding Rounds

$20.0m

Money raised

Outpost Medicine is a biopharmaceutical company focused on the development of novel therapeutics for the treatment of urologic and gastrointestinal disorders. Located in Indianapolis, IN and London, UK, Outpost is a private company launched in 2016.

Industries:

Location:

8

Funding Rounds

$42.5m

Money raised

SmarterHQ, Inc. is an Indianapolis-based company.

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