69 Best Startups in Chicago to Watch in 2025

C3 AI is an enterprise artificial intelligence software company providing a family of integrated products for accelerating digital transformation.

Elastic is a software company that creates products for searching for information on the Internet. It was founded in 2012 and is headquartered in San Francisco and Amsterdam.

Circle is a peer-to-peer payments technology company that is headquartered in Boston, Massachusetts and was founded in 2013 by Jeremy Allaire and Sean Neville.

Tempus, a technology company advancing precision medicine through the practical application of artificial intelligence in healthcare.

U.S-based 3D media technology company providing worldwide end-to-end virtual media solutions.

TradingView is a platform which provides instruments for publication and the viewing of trading ideas.

NOCD provides online therapy for obsessive-compulsive disorder (OCD).

Hologram is a company with a platform for building Internet of Things type products

Big Time is a multiplayer action RPG that makes collectable NFTs accessible to everyone.

Fetch Rewards is a mobile shopping platform for earning points and rewards on purchases.

Arturo.ai is a Chicago-based insurance technology and artificial intelligence company.

Kin Insurance is an insurance technology company offering home insurance founded in 2016.

Avail is a Chicago-based company developing free landlord software to help with rental property management.

Signature Bank is a New York City-based company founded in 2023.

Wickr is a telecommunications and security company that builds secure communication tools, such as a messaging application. It was founded in 2012 and is located in San Francisco, California.

Loop Crypto is an auto payment platform for on-chain crypto payments.

ShipBob is a company offering logistics services to small- to mid-sized businesses.

Addepar is a leading provider of technology for the wealth management industry. The company's performance reporting and analytics platform aggregates portfolio, market, and client data all in one place. It provides asset owners and advisors a clearer financial picture at every level, allowing them to make more informed and timely investment decisions. Addepar works with leading financial advisors, family offices, and large financial institutions that manage over $1.3 trillion of assets on the company's platform. In 2018, Addepar was named as a Forbes Fintech 50 and received Morgan Stanley's Fintech Award for making significant impact to the firm's mission of continuous innovation. Addepar is headquartered in Silicon Valley and has offices in New York, New York City, Chicago, Illinois, and Salt Lake City.

Project44 is a visibility platform for shippers and third-party logistics firms tracking the supply chain.

Fingerprint is a developer of an application programming interface designed for fraud detection on the modern web.

An insurance technology company offering a platform for insurance claims.

Zero Hash is a financial services company specializing in digital assets-as-a-service technology.

Nature's Fynd is a biotechnology company growing edible proteins founded in 2012.

An artificial intelligence company with a focus on developing solutions for the healthcare industry. It was founded in 2017 and is located in Tel Aviv, Israel.

Common is a NYC-based coliving company founded by Brad Hargreaves founded in 2015 by Brad Hargreaves.

Popular Pays is company providing a platform connecting brands with creators to produce custom content and generate awareness.

LotLinx is a marketing technology suite used in the American and Canadian automotive industry. It is an automotive VIN-specific digital marketing suite.

Fly.io is a Chicago-based platform for deploying full stack application servers and databases close to users.

Fast Radius is a Chicago, IL-based Mechanical and Industrial Engineering company.

EarlyBird is a platform for parents looking to invest for their children.

Wellspring Worldwide is an innovation and technology commercialization program that offers technology scouting, corporate venturing, licensing and intellectual property software for corporations and universities.

Avant is a company operating an online platform providing users access to personal loans. It utilizes big data and machine learning algorithms.

Rent the Runway is a New York City-based company founded in 2009 by Jennifer Hyman.

Instana is a SaaS-based application performance management (APM) platform based in Chicago, Illinois and in the Ohligs borough of Solingen, Germany.

Venzee is a software development company based in Vancouver, Canada. The company offers a cloud-based AI platform for online retailers and vendors.

BiomeSense, Inc. is a biotechnology company developing microbiome technologies for the collection, storage, and analysis of gut microbiome profiles.

CareSkore is a healthcare technology company that provides personalized population health management.

Clearcover is a smarter car insurance choice. We deliver the right coverage, when it matters, so you can pay less. Clearcover saves you money by applying advanced technology and only talking to you about insurance in moments that matter - like when you're buying a car, shopping for better insurance rates or managing your finances. With Clearcover, you get the same great coverage as Big Insurance, for up to 40% less per month. Follow along with our progress on Medium: https://medium.com/@ClearcoverInc or on Twitter @Clearcover

Elixir is a company that has developed a protocol for decentralized finance.

A developer of primary care clinics. VillageMD provides support services to physicians and to patients outside the office visit with aim of better clinical outcomes and enhanced patient experience.

Draftbit is a company that gives the option to build a cross-platform, native iOS and Android app.

Seed CX is a cryptocurrency company founded in 2017 by Brian Liston.

Uptake is a SaaS company that works with industrial companies to analyze and predict equipment performance.

Next Big Sound provides a dashboard, charts, and reports to monitor popularity, activity, and metrics for musicians, albums, authors and books across social media, sales and events.

Copado is a provider of a DevOps platform for Salesforce users.

GFX Labs is a technology company with a focus on developing decentralized finance products.

ActiveCampaign provides a platform with email marketing, marketing automation, and CRM tools for small-to-mid-sized businesses.

Peeranha is a question and answer (Q & A) website that rewards users with cryptocurrency.

A company offering a compliance platform for marketing cannabis products.

BlueCart is an online ordering platform that connects wholesale suppliers and buyers in the hospitality industry.

A technology company providing a commercial real estate asset management platform.

Flock Freight is a Solana Beach, California-based company that uses algorithmic pooling technology to allow less-than-truckload (LTL) shippers to share trailer space in one full truckload.

SPOTHERO, INC. is a Chicago-based company founded in 2011 by Mark Lawrence.

Software to power reservations, tickets, order delivery and pickup from restaurants.

A technology company provides an artificial intelligence-powered operational system for real estate developers and agents.

Livly is an AI-powered property management software company that simplifies apartment community operations, enhances resident experiences, and predicts lease renewals with AI tools and digital rewards.

Automated Insights is a Durham, North Carolina-based company offering content automation services and founded in 2007 by Robbie Allen.

FarEye is a Chicago-based company offering a delivery management platform for retail, e-commerce, and third party logistics companies.

Bringg is a company developing a delivery management platform.

Opternative is a series B startup that offers an online vision test to get a prescription for glasses and contacts from an ophthalmologist.

Food Genius is a Chicago-based company founded in 2010 by Justin Massa, Eli Rosenburg and Benjamin Stanley.

A financial services company offering a searchable platform for buy-side investors to access qualitative investment research.

SilkRoad Technology is a Chicago-based company founded in 2003 by Andrew Filipowski.

SMS Assist is a company providing exterior maintenance, facilities maintenance, interior maintenance, and property management services.

Tovala is a Chicago-based startup company marketing a countertop steam oven that comes with a meal kit subscription service.

RedShelf is a company. It provides an HTML5 cloud reader and marketplace to buy, sell and read eBooks, textbooks, academic materials, magazines, documents and other digital content.

Rise Interactive is a digital marketing company founded in 2004.

Twaice delivers solutions based on digital twins to reduce battery development and testing costs as well as to increase battery reliability and lifetime.

A blockchain company offering a platform for making alternative investments.