69 Best Startups in Cleveland to Watch in 2025

The Definitive Seedtable Ranking of Startups in Cleveland

We track 71,000+ companies and rank them dynamically using our Seedtable Score – a score that uses quantitative and qualitative data points to signal the momentum behind a company. We then monitor the list manually leveraging our expertise as founders and investors.

There are 93 start-ups with an aggregate funding of $1.7b. The average funding per company in this subset is $24.8m.

Last update to the database: Feb 18, 2025. See changelog.

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6

Funding Rounds

$211.9m

Money raised

Keyfactor is a software company that provides cloud-first PKI as a service and crypto-agility solutions.

8

Funding Rounds

$52.8m

Money raised

Remesh is an AI-based company to gather collective insights founded in 2013 by Aaron Slodov, Andrew Konya and Gary Ellis.

4

Funding Rounds

$46.7m

Money raised

Juventas Therapeutics is a biotechnology company founded in 2007 that is headquartered in Cleveland, Ohio developing a pipeline of regenerative therapies to treat life-threatening diseases.

1

Funding Rounds

$47.0m

Money raised

Vytalize Health is a company founded in 2014 by Faris Ghawi, Omar Elrabie and Amer Alnajar.

1

Funding Rounds

$1.2m

Money raised

Votem is a Cleveland-based company founded in 2014 by Pete Martin.

2

Funding Rounds

$31.0m

Money raised

Fund That Flip is a company founded in 2014 by Matt Rodak.

3

Funding Rounds

$8.5m

Money raised

Digitizing the process of vehicle titling to create a legal, digital title that is easily transferable and verified.

5

Funding Rounds

$34.0m

Money raised

Cleveland Diagnostics, Inc. is a Cleveland-based company developing technology to detect cancer early founded in 2013.

2

Funding Rounds

$13.4m

Money raised

Provider of a workforce intelligence network for healthcare intended to streamline workforce deployment, drive efficiencies and maximize revenue.

6

Funding Rounds

$35.9m

Money raised

Industrial Origami is a software company that uses patented technology.

3

Funding Rounds

$11.5m

Money raised

EmployStream is a Cleveland-based company founded in 2014 by Rob Sable.

2

Funding Rounds

$3.8m

Money raised

SparkBase is a Cleveland-based company founded in 2004.

4

Funding Rounds

$1.4m

Money raised

Hakka Therapuetics is a biotechnology company, based in Cleveland.

1

Funding Rounds

$1.7m

Money raised

MedPilot Inc. is a company founded in 2014 by Matt Buder Shapiro, Leonard Law, Jacob Myers, Jordan Brown and Rakinur Alam.

3

Funding Rounds

$30.3m

Money raised

SPR Therapeutics is a nerve Stimulation Therapy founded in 2010 by Maria E. Bennett.

2

Funding Rounds

$20.3m

Money raised

BoxCast is a Cleveland-based company founded in 2013 by Gordon Daily.

1

Funding Rounds

$250.0k

Money raised

BigRiver is a company founded in 2011.

1

Funding Rounds

$21.0m

Money raised

BioMotiv is a company focused on advancng therapeutics development founded in 2012.

1

Funding Rounds

Grasshopper capital is a cryptocurrency hedge fund that is headquartered in Wilmington, Delaware and was founded in 2017 by Ari Lewis and Sagar Rambhia.

3

Funding Rounds

$3.0m

Money raised

ShotStop Ballistics LLC is a Stow, Ohio-based company founded in 2015 by Vall Iliev.

Industries:

Location:

1

Funding Rounds

$900.0k

Money raised

Wisr is a Cleveland-based company founded in 2016 by John Knific, Kris Ciccarello and Kate Volzer.

3

Funding Rounds

$25.8m

Money raised

Sundays for Dogs, Inc. is a company founded by Michael Waxman.

1

Funding Rounds

$44.3m

Money raised

Splash Financial is a leading, online platform that helps hardworking graduates to refinance their student loans and reach financial freedom. With loans funded by banks and credit unions, Splash Financial ensures market-leading rates, no application or origination fees, and simplified monthly payments. In under 3 minutes, customers can check their pre-qualified rates using Splashï intuitive online rate check œ all without affecting their credit score.

2

Funding Rounds

$120.0m

Money raised

Within3 is a company founded by Anthony Broad-Crawford.

1

Funding Rounds

$7.0m

Money raised

7signal Solutions, Inc. is a company founded in 2008 by Marko Pirinen.

2

Funding Rounds

$16.6m

Money raised

Splash Financial is a Cleveland-based company founded in 2013 by Steven Muszynski.

4

Funding Rounds

$8.0m

Money raised

LineStream Technologies is a Cleveland-based company founded by Zhiqiang Gao.

1

Funding Rounds

$45.0m

Money raised

OnStation is a company founded in 2015 by David Raboy .

2

Funding Rounds

$33.1m

Money raised

Cleveland HeartLab is a clinical laboratory and cardiovascular disease management company.

Location:

2

Funding Rounds

$9.9m

Money raised

Checkpoint Surgical is a Cleveland-based healthcare company.

Industries:

Location:

3

Funding Rounds

$6.2m

Money raised

Thermalin Inc. is a reengineered insulin founded in 2007.

1

Funding Rounds

Data Genomix is an artificial Intelligence company founded in 2016.

Location:

1

Funding Rounds

$125.0k

Money raised

Quixby is a Cleveland-based company founded by Austin Kettner.

3

Funding Rounds

$56.4m

Money raised

Blue Spark Technologies is a Cleveland-based company founded in 2003.

Industries:

Location:

1

Funding Rounds

$6.2m

Money raised

AlgiSys is a Cleveland-based company founded in 2009.

4

Funding Rounds

$27.0m

Money raised

Diabetes & Obesity Therapies

2

Funding Rounds

$1.2m

Money raised

60mo is a Cleveland-based company founded in 2009 by Ed Buchholz.

2

Funding Rounds

$335.0k

Money raised

Solace Vision is a Cleveland-based company.

1

Funding Rounds

$7.0m

Money raised

Trailhead CFR now Complion is a Cleveland-based company founded in 2013.

2

Funding Rounds

$24.1m

Money raised

Felux is a Cleveland-based company.

Industries:

Location:

1

Funding Rounds

$1.8m

Money raised

Heureka Software is a Cleveland-based company founded in 2014.

1

Funding Rounds

$7.5m

Money raised

Vox Mobile is a company founded in 2006.

2

Funding Rounds

$43.0m

Money raised

Centerline Biomedical is a Cleveland-based company founded in 2014.

2

Funding Rounds

$2.3m

Money raised

Theravasc is a biotechnology company developing therapeutics for vascular diseases.

Location:

4

Funding Rounds

$21.4m

Money raised

StreamLink Software is a Cleveland-based company.

2

Funding Rounds

$97.6m

Money raised

Hni Healthcare is a company founded in 2009.

1

Funding Rounds

$1.8m

Money raised

GenomOncology is a Cleveland-based company founded in 2012.

1

Funding Rounds

$9.2m

Money raised

Nanoparticle technologies that enable and improve drug uptake and retention into the cell for medical devices

2

Funding Rounds

$2.2m

Money raised

S4 Medical Corp. is a Cleveland-based company founded in 2017 by Bill Fuller.

Location:

1

Funding Rounds

$44.0m

Money raised

Macropoint, Llc is a company founded in 2009.

1

Funding Rounds

$1.4m

Money raised

Tpa Stream is a Cleveland-based company founded in 2014.

Industries:

Location:

5

Funding Rounds

$6.9m

Money raised

Proformex, LLC is a Cleveland-based company founded in 2016.

1

Funding Rounds

$25.0m

Money raised

Fello is a Cleveland-based company founded by Ryan Young.

Location:

5

Funding Rounds

$18.5m

Money raised

1

Funding Rounds

$1.1m

Money raised

My One Medical Source aims to connect patients with medical professionals, lab facilities and phlebotomists.

Industries:

Location:

1

Funding Rounds

BIOHM Health is a Cleveland-based supplements company developing dietary supplements and probiotics.

Location:

1

Funding Rounds

$7.0m

Money raised

Complion is a Cleveland-based company founded in 2013.

1

Funding Rounds

$7.8m

Money raised

Snip Internet Llc is a Cleveland-based company founded in 2016.

1

Funding Rounds

$4.5m

Money raised

Polar Delight Inc is a Cleveland-based company founded in 2018.

Location:

1

Funding Rounds

$250.0k

Money raised

Milo Biotechnology is a gene Therapy.

1

Funding Rounds

$250.0m

Money raised

MAI Capital Income & Growth Fund V QP, L.P. is a Cleveland-based investment management company founded in 2019.

Industries:

Location:

1

Funding Rounds

$100.0m

Money raised

MAI Capital Income & Growth Fund V QC, L.P. is a Cleveland-based investment management company founded in 2019.

Industries:

Location:

1

Funding Rounds

$10.0m

Money raised

Decent is a Cleveland-based finance company founded in 2017.

Industries:

Location:

1

Funding Rounds

$1.0

Money raised

Ancora Catalyst SPV I LP - Series B is a Cleveland-based company founded in 2019.

Location:

1

Funding Rounds

$1.0

Money raised

Ancora Commodity Fund LP is a Cleveland-based company founded in 2019.

Location:

1

Funding Rounds

$9.0m

Money raised

orthobrain is a Cleveland-based company founded by Dan German.

Location:

2

Funding Rounds

$24.8m

Money raised

Checkpoint Surgical is a Cleveland-based company.

Location:

1

Funding Rounds

$1.3m

Money raised

Sotera Medical Corp. is a Cleveland-based company founded in 2017.

Location:

1

Funding Rounds

$1.0m

Money raised

72 CHOCOLATE LLC is a Cleveland-based company founded in 2019.

Location:

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