69 Best Blockchain And Cryptocurrency Startups in United States to Watch in 2025

Tendermint is now Ignite. Tendermint was the core contributor to the Cosmos blockchain network.

Numerai is a hedge fund with stock market trades determined by crowdsourced artificial intelligence models. The best models receive rewards in the form of a cryptographic token called Numeraire (NMR) on the Ethereum blockchain.

CryptoKitties is a game built on the Ethereum blockchain in which users can collect and trade virtual kittens.

Celo is an open platform that offers financial tools to mobile phone users.

Immunefi is a bug bounty security services platform that focuses on bug bounty and security services for Web3 projects.

Layer1 is a cryptocurrency investment and infrastructure platform.

Splinterlands is a digital trading card game built on blockchain technology.

Ondo Finance is an open, permissionless, decentralized investment bank

Mysten Labs creates foundational infrastructure to accelerate the adoption of Web3.

Bitmain is a Beijing-based multinational semiconductor company, founded in 2013, that manufactures products for blockchain and artificial intelligence (AI) applications.

A web and API platform that provides Bitcoin and Altcoin conversion.

Zeta Markets is the premier derivatives protocol on Solana.

Praxis is a membership-based community of creatives and technologists building a city-cryptostate.

Cake is an all-in-one decentralized finance (DeFi) platform.

Wise, previously TransferWise, is a company that offers money transfers services founded by Kristo Käärmann and Taavet Hinrikus.

ItBit is a platform for institutions and active investors to trade cryptocurrency assets.

SynFutures is a decentralized Derivatives Protocol.

P2E game build on Solana blockchain. Grab your mask and start your journey - level up from card strategy battle game to full MMO glory!

O3 Labs is a Japanese startup that offers a range of cryptocurrency services for an undisclosed price.

BTC-Alpha is a cryptocurrency exchange platform.

Primitive - Crypto derivative products built on the Replicating Market Maker protocol, an oracle-free solution to scalable and efficient on-chain derivatives.

Regulated crypto exchange. Built the world's first regulated tokenised assets platform. It aims to revolutionise cryptocurrency investment.

Bitso is a cryptocurrency exchange for buying and selling Bitcoin, Ethereum, Litecoin, Bitcoin Cash, TrueUSD, Decentraland, Golem, and Basic Attention Token.

The Arianee is a multichain token and protocol built on both the Ethereum core network and the Ethereum sidechain called POAnetwork.

BlockFi is a blockchain platform for high-interest crypto accounts and low-cost credit products.

Juno, previously known as OnJuno, is a neobanking platform that offers interest-earning personal checking accounts. The platform allows all transactions to be managed from an iPhone or Android application, and users can be paid in cryptocurrency through direct deposit.

The Ajuna platform provides a simplified way for Unreal and Unity developers to build an incentive layer into their games using tokenized virtual goods.

Mavia is a multiplayer allotment-based strategy game that allows players to build, develop their army, and own property using in-game resources and the RUBY cryptocurrency.

ArDrive is a blockchain-based storage App.

VALR is a company founded in 2018 by Farzam Ehsani, theo bohnen and badi sudhakaran.

Ceramic is a public, decentralized, censorship-resistant network for managing mutable information on the open internet without databases or servers

Luno is a cryptocurrency company founded in 2013 by Marcus Swanepoel.

Aztec is an open source layer 2 network.

Upland is a property trading metaverse connected to real-world addresses.

Bitski is a company making a dApp wallet SDK for decentralized applications.

Lit Protocol is decentralized access control designed to bring more utility to the web.

Also known as the Daily Muse, The Muse is a company developing an online career platform that provides job listings and career advice to people. It participated in the W12 cohort of Y Combinator. It was founded in 2011 and is located in New York City, New York.

Rentberry is a home rental platform offering decentralized, global, long term rental solution for tenants and landlord.

Airwaive is an online marketplace that connects wireless service providers with home and business owners who earn an income operating wireless access points.

Facial recognition company Kairos today announced the alpha release of the Kairos Protocol, a biometric verification system for cryptocurrency transactions.

Abra offers a cryptocurrency trading application created to streamline online cryptocurrency transfers and investments.

Uphold (formerly Bitreserve) is a cloud-based digital money platform. Users can buy, hold, convert and transact across currencies and commodities, including cryptocurrencies.

Unikrn is a Seattle-based eSports betting site. The company was acquired by Entain in 2021.

Messari is a cryptocurrency data and analytics firm. It's mission is to promote transparency and smarter decision-making in the cryptoasset community. Their open-source data library helps researchers, investors, and regulators make sense of the industry.

Chronicled is a blockchain company founded by Ryan Orr, Samantha Radocchia, Maurizio Greco and David Aho.

Crypto hedgehog is a San Jose, CA-based investment management software company providing a portfolio management app for cryptocurrencies.

A decentralized capital market powered by a cross-margin cross-collateralization clearing engine protocol.

InfStones is a blockchain staking and infrastructure platform that aims to make Web3 ecosystems more accessible.

Nebula Genomics is a genetics company developing a platform for individuals to get their personal genome sequenced, and then enable them to store and control that information through cryptographic encryption on the blockchain.

Hex Trust is a fully-licensed and insured provider of bank-grade custody for digital assets.

Anchorage Digital is a global regulated crypto platform that provides institutions with integrated digital asset financial services and infrastructure solutions.

VeriTX Corp. is an East Aurora, New York-based developer of digital supply chain platform, marketplace, and related products and applications offering technologies to secure digital supply chain solutions and data integrity solutions.

Keyfactor is a software company that provides cloud-first PKI as a service and crypto-agility solutions.

Evernym is a software company that develops an open source sovereign identity block chain.

Moon is a crypto payment platform.

NameBase is a cryptocurrency Exchange founded in 2018.

Mudrex offers a cryptocurrency investment platform

A blockchain and cryptocurrency development company developing blockchain based business solutions for investment funds, administrators, trading firms, exchanges and accounting firms.

Cryptoys blends collectibles, gaming, and entertainment to unlock a whole new world of possibilities.

Blocknative is a provider of real-time blockchain transaction management and monitoring solutions for public blockchain networks.

Valora is built on Celo, a carbon-negative blockchain.

RabbitHole is building a guide through Web3 for contributors to learn how to use and contribute to decentralized apps while earning tokens based on on-chain activity.

Aperture Finance is a cross-chain marketplace for investing strategies in the decentralized finance domain.

FalconX is a blockchain, cryptocurrency, and fintech-focused brokerage and digital asset trading platform.

Autograph is an NFT platform that brings together the iconic brands in sports and culture to create unique digital collections.

KurateDAO is a blockchain-based databased for Web3 applications.

Sense Finance is an adding Dimension to DeFi founded in 2021 by Kenton Prescott.

X-Margin enables data-driven and transparent lending across CeFi and DeFi using real-time privacy-preserving monitoring.

Social Money. Creators can make their own tokens and distribute to their community as they want. Community as a digital asset.