69 Best Startups in Duluth Minnesota to Watch in 2025

The Definitive Seedtable Ranking of Startups in Duluth Minnesota

We track 71,000+ companies and rank them dynamically using our Seedtable Score – a score that uses quantitative and qualitative data points to signal the momentum behind a company. We then monitor the list manually leveraging our expertise as founders and investors.

There are 309 start-ups with an aggregate funding of $2.6b. The average funding per company in this subset is $37.9m.

Last update to the database: Feb 18, 2025. See changelog.

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8

Funding Rounds

$220.0m

Money raised

Just, Inc. (formerly known as Hampton Creek) is a food technology company developing and selling plant based food products around the world.

8

Funding Rounds

$551.0m

Money raised

Eat Just is a San Francisco based food technology company founded in 2011. The company is known for its bean-based egg substitute called Just Egg. Eat Just also produces egg-free mayonnaise.

5

Funding Rounds

$69.9m

Money raised

75F is a Bloomington, Minnesota-based technology company offering an Internet of Things (IoT) building automation system for HVAC, lighting, and equipment control.

6

Funding Rounds

$144.3m

Money raised

An insurance technology company offering a platform for consumers to purchase and manage their healthcare expenses.

1

Funding Rounds

$61.8k

Money raised

The Herbivorous Butcher is a vegan meat shop creating meat-free meats and cheese-free cheeses. Siblings Aubry and Kale Walch founded The Herbivorous Butcher in 2013 in Minneapolis, Minnesota, with the mission to promote healthy and ethical eating.

1

Funding Rounds

$3.0m

Money raised

Zipnosis is a telemedicine healthcare provider based in Minneapolis, Minnesota.

Location:

1

Funding Rounds

$3.0m

Money raised

Anno.ai is a Reston, VA-based company developing artificial intelligence technologies for the defense sector.

5

Funding Rounds

$14.6m

Money raised

A technology company offering a pocket-sized portable near infrared spectrometer for discovery the makeup of materials.

1

Funding Rounds

$50.0m

Money raised

Digital River is a private company that provides global e-commerce, payments and marketing services. In 2013, Digital River processed more than $30 billion in online transactions. Digital River is headquartered in Minnetonka, Minnesota.

11

Funding Rounds

$67.4m

Money raised

Recombinetics is a biotechnology company that uses gene editing for agriculture and medicine

9

Funding Rounds

$21.0m

Money raised

A for-profit blockchain-as-a-service software company aiming to help solve extreme poverty.

1

Funding Rounds

$280.0k

Money raised

Core Security provides threat-aware identity, access, authentication and vulnerability management solutions.

4

Funding Rounds

$144.0m

Money raised

Developer of an enterprise-grade marketing and customer engagement platform designed to assist businesses to empower their sales teams for growth. The company's platform aligns marketing, sales and compliance departments in one system, offering the simple creation, distribution and reporting of all marketing materials, enabling businesses to gain greater oversight and audit-ready compliance, fueling fast and confident decisions.

5

Funding Rounds

$4.4m

Money raised

Geneticure is a Rochester, New York-based company developing pharmacogenomic tests for treating non-communicable diseases.

4

Funding Rounds

$1.7m

Money raised

Exosite is a Minneapolis-based enterprise software company founded in 2009.

1

Funding Rounds

$25.0m

Money raised

Edmentum is a provider of online, mobile, and software-based education products, including interactive instructional and testing platforms with curriculum, instructional management, and assessment tools for instructors.

2

Funding Rounds

$140.0m

Money raised

Saluda Medical is a commercial-stage medical device company that develops treatments for chronic neurological conditions.

4

Funding Rounds

$224.0m

Money raised

Developer of a human resource management platform designed to help hourly employees and managers work better together.

2

Funding Rounds

$105.6m

Money raised

Sezzle is a Minneapolis-based payment platform offering users buy now, pay later services.

3

Funding Rounds

$36.3m

Money raised

Rebiotix is a company that is deveoloping microbiota restoration therapy for the treatment of gastrointestinal diseases.

3

Funding Rounds

$86.0m

Money raised

A company that develops therapies to relieve patients with chronic back pains

1

Funding Rounds

$1.1m

Money raised

Lifengine Animal Health Laboratories or LEAH Labs is a biotechnology company providing Car T cells to cure cancer in dogs.

6

Funding Rounds

$39.4m

Money raised

Vibenomics powers audio out-of-home advertising and experiences for brands and location-based organizations.

2

Funding Rounds

$12.0m

Money raised

POPS! Diabetes Care's mission is to empoTheyr diabetic patients to live life to the fullest. Their solution includes an integrated blood glucose meter that fits on the back of your phone, a mobile app to enhance self-management, and a Theyb app to enhance supported-management.

1

Funding Rounds

$1.0m

Money raised

Imanis Life Sciences is a company developing solutions for noninvasive imaging.

3

Funding Rounds

$35.0m

Money raised

Zecco is a company founded in 1919.

2

Funding Rounds

$5.0m

Money raised

Aker Technologies is a company founded in 2016.

2

Funding Rounds

$3.0m

Money raised

Biotectix focuses on the development of bioactive conductive polymer electrodes and coatings for electrodes for medical devices.

6

Funding Rounds

$23.2m

Money raised

CIVIC EAGLE, INC. is a company founded in 2015.

1

Funding Rounds

Zubie is a connected-car platform that provides location tracking, driver scoring, alert and location sharing services.

1

Funding Rounds

$36.8m

Money raised

Image Guided Therapy Solutions

6

Funding Rounds

$715.6k

Money raised

Regenhu Limited is a biotechnology company that aims to develop bioprinting technologies that will positively impact many medical fields.

3

Funding Rounds

$4.9m

Money raised

ReconRobotics, Inc. is an advanced robotics company.

Industries:

Location:

1

Funding Rounds

Sophia is a company founded in 2012.

3

Funding Rounds

$4.0m

Money raised

Luminary Therapeutics is a Minneapolis-based biotechnology company focused on allogeneic therapeutics.

1

Funding Rounds

$3.2m

Money raised

Kidizen is a company founded in 2014.

Location:

1

Funding Rounds

$8.0m

Money raised

Central Logic is a Sandy, Utah-based software company.

Industries:

4

Funding Rounds

$34.1m

Money raised

Niron Magnetics is a Minneapolis-based company founded by Jian-Ping Wang.

3

Funding Rounds

$3.2m

Money raised

The nanodropper is a universal adapter for eye droppers to reduce cost and increase access to expensive eye prescription medications.

2

Funding Rounds

$2.8m

Money raised

AI assistant designed to break down food science, consumer insights, marketing research, and more

3

Funding Rounds

$14.0m

Money raised

A company offering technology-based care solutions and services for the senior care

1

Funding Rounds

$1.3m

Money raised

Developer of a finance platform intended to connect the entire agricultural chain to the capital market.

3

Funding Rounds

$40.0m

Money raised

Dayforce is a human capital management software developed by Ceridian.

2

Funding Rounds

$6.0m

Money raised

BoonLogic is a technology company that is centered in the area of machine learning.

8

Funding Rounds

$8.4m

Money raised

CARDIA, INC. is a transcatheter septal occluders developer, manufacturer, and marketer.

4

Funding Rounds

$4.9m

Money raised

Nimbelink Corp is a company founded in 2013 by Scott Schwalbe.

1

Funding Rounds

$15.0m

Money raised

Tru Shrimp is a Balaton, Minnesota-based company that raises shrimp through the use of aquaculture.

1

Funding Rounds

$682.2k

Money raised

A company developing diagnostic device and software for the detection and treatment of vascular disease

4

Funding Rounds

$27.9m

Money raised

A company developing medical diagnostic products

3

Funding Rounds

$10.4m

Money raised

Hidrate is a retail company founded in 2014 by Ngoc (Nadya) Nguyen, Alexandra Feeken, Coleman Iverson and Alexander Hambrock.

4

Funding Rounds

$38.1m

Money raised

Cima NanoTech is a company that develops modern transparent conductive film solutions.

1

Funding Rounds

$4.3m

Money raised

OpenLogic is a Minneapolis-based company founded in 1999.

1

Funding Rounds

$1.5m

Money raised

ilos videos is a Saint Paul, Minnesota-based company founded in 2012 by Nick Stokman, Peter Fares and Sean Higgins.

2

Funding Rounds

$67.3m

Money raised

Vyriad is a Rochester, Minnesota-based company founded in 2015.

2

Funding Rounds

$35.0m

Money raised

Nice Healthcare is a company founded in 2017 by Thompson Aderinkomi.

$240.0k

Money raised

Platform enabling language teachers to create and share interactive learning materials.

1

Funding Rounds

$90.0m

Money raised

NetSPI is an information security penetration testing and vulnerability assessment management advisory firm.

1

Funding Rounds

$30.0m

Money raised

JAMF Software is a Minneapolis, MN-based company which makes and distributes device management software for companies which need to track and manage a distributed fleet of Apple computers.

3

Funding Rounds

$48.5m

Money raised

A company developing technologies and surgical techniques to treat herniated discs

1

Funding Rounds

$6.3m

Money raised

Estify is a company founded in 2012.

1

Funding Rounds

$7.0m

Money raised

Qterics is a company that has years of experience in helping large international companies to create, enhance, and support quality products in the consumer market.

Industries:

2

Funding Rounds

$10.0m

Money raised

Finance Management Platform for Car Dealerships

1

Funding Rounds

$3.1m

Money raised

A medical device company developing devices focused on spinal cord injury and disease

1

Funding Rounds

$11.2m

Money raised

SilkTech is a clinical stage company using the natual therapeutic properties of silk derived proteins to develop drugs for Dry Eye Disease.

1

Funding Rounds

$256.0k

Money raised

Silicon Prairie Online is a Saint Paul, Minnesota-based company founded in 2016 by David Duccini.

1

Funding Rounds

$4.1m

Money raised

A company developing magnetic resonance imaging (MRI) compatible devices and systems

1

Funding Rounds

$2.0m

Money raised

Phenomix Sciences LLC is a Saint Paul, Minnesota-based biotechnology company developing genomic testing services and systems for the personalized management of chronic diseases.

$72.6k

Money raised

We create passion and commitment with listening and engaging employees, teams and executives. SaaS service for B2B.

1

Funding Rounds

$2.0m

Money raised

Digital Health program focused on improving life quality for women.

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