10 Best Silk Startups to Watch in 2025

The Definitive Seedtable Ranking of Silk Startups

We track 71,000+ companies and rank them dynamically using our Seedtable Score – a score that uses quantitative and qualitative data points to signal the momentum behind a company. We then monitor the list manually leveraging our expertise as founders and investors.

There are 10 start-ups with an aggregate funding of $1.9b. The average funding per company in this subset is $192.3m.

Last update to the database: Feb 18, 2025. See changelog.

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Bolt Threads logo

Bolt Threads

Bolt Threads is a biotechnology company that makes high performance fabrics and materials using biology.

8

Funding Rounds

$406.4m

Money raised

Spiber, Inc. logo

Spiber, Inc.

Spiber, Inc is a private biomaterials company using industrial biotechnology to develop silk.

13

Funding Rounds

$1.1b

Money raised

AMSilk logo

AMSilk

AMSilk is a Munich-based synthetic biology company that produces fibers made from the same protein as spider silk.

6

Funding Rounds

$129.3m

Money raised

Vaxess Technologies logo

Vaxess Technologies

A medical company in Massachusetts focusing on lowering the cost of vaccine distribution.

14

Funding Rounds

$87.2m

Money raised

Kraig Biocraft Laboratories logo

Kraig Biocraft Laboratories

A biotechnology company developing and commercializing spider silk for textiles and performance polymers. Kraig Biocraft Laboratories uses genetic engineering to produce recombinant spider silk based fibers on an industrial scale.

4

Funding Rounds

$14.0m

Money raised

EV Biotech logo

EV Biotech

EV Biotech is a microbial cell factory (MCF) strain development company.

1

Funding Rounds

$4.7m

Money raised

Xampla logo

Xampla

Xampla is a Cambridge, Cambridgeshire-based company founded in 2018 by Tuomas Knowles.

2

Funding Rounds

$11.0m

Money raised

Evolved by Nature logo

Evolved by Nature

Evolved by Nature developed technology for activating silk proteins from silkworm cocoons and are leveraging that material for use in various products.

1

Funding Rounds

$120.0m

Money raised

Cocoon Biotech logo

Cocoon Biotech

Cocoon Biotech is a biocompatible silk protein founded in 2013 by Ailis Tweed-Kent.

1

Funding Rounds

$865.4k

Money raised

SilkTech logo

SilkTech

SilkTech develops naturally derived silk protein for use in healthcare and consumer goods products.

1

Funding Rounds

$6.0m

Money raised