29 Best Startups in Knoxville Tennessee to Watch in 2025

The Definitive Seedtable Ranking of Startups in Knoxville Tennessee

We track 71,000+ companies and rank them dynamically using our Seedtable Score – a score that uses quantitative and qualitative data points to signal the momentum behind a company. We then monitor the list manually leveraging our expertise as founders and investors.

There are 29 start-ups with an aggregate funding of $595.0m. The average funding per company in this subset is $20.5m.

Last update to the database: Feb 18, 2025. See changelog.

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4

Funding Rounds

$310.0m

Money raised

Verana Health is a U.S.-based company which provides a data platform and databases for life science research and patient care.

4

Funding Rounds

$9.1m

Money raised

Flashback Technologies is a medical device company.

2

Funding Rounds

Fiveworx is a US-based SaaS marketing automation platform founded in 2014 by LeeAnn Head, and Suzanne Shelton.

7

Funding Rounds

$1.6m

Money raised

Mobius is a Knoxville, Tennessee-based bioplastic and biorefinery company founded in 2016 by Jeffrey Beegle and Tony Bova.

1

Funding Rounds

$7.0m

Money raised

ContinuumRx is a company providing home infusion therapies and services.

2

Funding Rounds

ElectroActive Technologies is a company that was spun out of Oak Ridge National Laboratory based on the research that was done.

13

Funding Rounds

$111.5m

Money raised

Lirio, LLC is a Knoxville, Tennessee-based company founded in 2016.

3

Funding Rounds

$2.5m

Money raised

A medical device company developing and commercializing immunodiagnostic tests

1

Funding Rounds

$12.5m

Money raised

A recycling technology for ecovery of the metals from e-waste for reuse in the clean energy sector.

1

Funding Rounds

$1.5m

Money raised

A biopharmaceutical company developing and commercializing protein therapeutics for skin damage treatment

1

Funding Rounds

$3.4m

Money raised

Arkis BioSciences® is a medical device company providing advanced implantable technology and minimally invasive surgical instrumentation.

1

Funding Rounds

$3.0m

Money raised

IdleAir is a Knoxville, Tennessee-based transportation company founded in 2003.

Industries:

1

Funding Rounds

$20.0m

Money raised

REGSCALE, INC. is a company founded by Anil Karmel.

13

Funding Rounds

$561.8k

Money raised

Bankers Title of East Tennessee LLC is a Knoxville, Tennessee-based company.

1

Funding Rounds

$2.6m

Money raised

PROVECTUS PHARMACEUTICALS is a company developing therapies that destroy cancers.

2

Funding Rounds

$400.0k

Money raised

Winter Innovations, Inc. is a Knoxville, Tennessee-based company founded in 2019.

1

Funding Rounds

$1.3m

Money raised

INSIGHT OPTIX LLC is a company founded in 2018.

1

Funding Rounds

$3.0m

Money raised

VisiRose offers an innovative approach to treating infectious keratitis and other eye diseases.

6

Funding Rounds

$51.0m

Money raised

GENERAL GRAPHENE Corp is a Knoxville, Tennessee-based company.

1

Funding Rounds

$2.0m

Money raised

Electro-Active Technologies, Inc. is a Knoxville, Tennessee-based company founded in 2019.

1

Funding Rounds

$1.8m

Money raised

Vendor Registry is a Knoxville, Tennessee-based e-commerce company founded in 2011.

Industries:

1

Funding Rounds

$500.0k

Money raised

Courseflow, Inc. is a Knoxville, Tennessee-based company.

1

Funding Rounds

$14.0m

Money raised

Charlotte Tryon Hills Partners, LLC is a Knoxville, Tennessee-based company founded in 2016.

1

Funding Rounds

$150.0k

Money raised

Cloud Retriever Inc. is a Knoxville, Tennessee-based company.

1

Funding Rounds

$600.0k

Money raised

HOA.Works, LLC is a Knoxville, Tennessee-based company founded in 2022.

1

Funding Rounds

$3.0m

Money raised

Aro Technology, Inc. is a Knoxville, Tennessee-based company founded in 2019.

1

Funding Rounds

$1.5m

Money raised

LumeNXT LLC is a Knoxville, Tennessee-based company founded in 2018.

1

Funding Rounds

Vitro Foods Inc. is a Knoxville, Tennessee-based company founded in 2020.

1

Funding Rounds

$30.6m

Money raised

Blühen Botanicals is a Knoxville, Tennessee-based company.

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